Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
01 January 2018 Photo Charl Devenish
ISG’s Sarah Frank researches impact of historic conflicts on society
Dr Sarah Frank, postdoctoral researcher at the ISG.

History has an interesting connection with society, as we all grow up learning about our country’s history and studying it at school. However, what we learn at school is often a glorified version of events. It can sometimes be challenging for historians to come to grips with the most accurate version of a particular ‘history’. 

Dr Sarah Frank is a postdoctoral research fellow with the International Studies Group (ISG), who fell in love with history at a young age. She says, "I was very lucky to have outstanding history teachers at school who fostered my interest and curiosity." Early on, though, she experienced disappointment. "In school, there was a series of biographies of American leaders and presidents written for children. I remember feeling betrayed when I subsequently learnt that the biographies had not presented a well-balanced narrative. That is when I learnt that history could be debated and interpreted—and it is full of nuances."

Interested in conflict shaping lives

Dr Frank was particularly intrigued by the social and political history of the Second World War (WWII). She describes her interest in this way: "The Second World War looms in popular memory as much as in the historical one. I am interested in how conflict shaped people’s lives during and after the war." Being a speaker of French helped her to focus on the impact of the war on France, and having spent a few years living in West Africa, confronted with the lingering colonial past, she decided to home in on the French empire, with particular attention to colonies, captivity, and the repercussions of war experiences when soldiers returned home. Additionally, she explores the themes of decolonisation, the roots of independence movements, and the lingering ties between the former imperial powers and former colonies.

Although she grew up near Boston, Massachusetts, studied for her master's in Dublin, and has lived in far-flung places such as Guinea (while serving with the Peace Corps) and Dakar, Dr Frank says, "I have lived in a lot of places, but Bloemfontein is definitely one of my favourites!"

“I was very lucky to have outstanding
history teachers at school who
fostered my interest and curiosity.”
Dr Sarah Frank

Colonial POWs her new focus

Currently, Dr Frank is writing a book based on her PhD research, which delved into the experiences of approximately 85 000 soldiers in captivity from across the French Empire, who fought in France from 1939-1940. The Germans decided to racially separate the colonial prisoners of war (CPOWs), taking white prisoners to Germany and leaving the colonial prisoners in camps across occupied France. This created opportunities for colonial prisoners to interact with the French civilians, something which rarely occurred in the strict hierarchical colonial regime. Perhaps surprisingly, considering the racism of both the French and German regimes, Colonial prisoners fared better in captivity in France than their French counterparts did in Germany.

Dr Frank's next project will trace the return of the African soldiers who fought during the Second World War. She seeks to understand what happened to them as well as their families when they returned, and to see if their experience actually impacted the growing independence movements which arose following 
WWII.

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept