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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

UFS leads international conference
2010-05-13

Here Minister Naledi Pandor is introduced to Prof. Martin Kropff, Rector of the Wageningen University and Research Centre in the Netherlands. Looking on are Prof. Aldo Stroebel and Melody Mentz.
– Photo Supplied.
The Third Biannual Conference of the International Network of Research Management Societies (INORMS) was held in Cape Town, South Africa during April 2010. The conference was co-hosted by the Southern African Research and Innovation Management Association (SARIMA) and the Association of Commonwealth Universities (ACU). It was the first time that the conference was held in Africa. The conference was attended by more than 400 delegates, representing more than 40 countries around the globe, and was officially opened by Minister Naledi Pandor, Department of Science and Technology (DST). The University of the Free State (UFS) took the lead in organising this event, with Prof. Aldo Stroebel, Vice-President of SARIMA and Director: Internationalisation at the UFS, as Conference President, and Prof. Frans Swanepoel, Director: Research Development at the UFS, as Chairperson of the Programme Committee. Other UFS staff who were members of the organising committee included Melody Mentz (Student Development and Success) and Lise Kriel (Planning Unit). Prof. Driekie Hay, Vice-Rector: Teaching and Learning, participated in a panel discussion on research leadership.

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