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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Prof Conradie makes UFS proud with prestigious Chemistry award
2015-03-25

Prof Jeanet Conradie and Dr Karel von Eschwege

Photo: Leonie Bolleurs

Prof Jeanet Conradie, Professor in the Department of Chemistry at the University of the Free State (UFS), has received the Merck Medal for 2014 from the South African Chemistry Institute (SACI), for her paper Redox potentials of ligands and complexes. A DFT approach, S. Afr. J. Chem. 2011, 64, 203-209.

Dr Karel von Eschwege, the co-author of the paper is also from the Department of Chemistry.

The medal is awarded to the senior author of the paper, published in the South African Journal of Chemistry in a specific field of chemistry, that is judged to have made the most significant contribution to the discipline. The award for 2014, covering papers published in the period 2010 to 2013, was in the field of Inorganic Chemistry.

As part of the award, Prof Conradie will deliver the Merck Medal Lecture at the presentation ceremony.

In 2014, Prof Conradie was runner-up in the senior category for Distinguished Women Researchers: Physical and Engineering Science in the Department of Science and Technology’s 2014 Women in Science Awards. The Academy of Science of South Africa (ASSAf) also invited her to become a member.

Prof Conradie believes to reach a goal, you have to utilise opportunities that come your way. “Remember, results speak for themselves. Any researcher can prove himself or herself this way. Nothing in life is for free; you need to work very, very hard. This is only possible when you love and enjoy your work,” she said.

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