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19 July 2018 Photo Supplied
AEVGI advances Next-Generation Sequencing in Africa
Prof George Armah, Noguchi Memorial Institute for Medical Research, Ghana; Prof Carl Kirkwood, Bill and Melinda Gates Foundation, USA; Cornelius Hagenmeier, Director: Internationalisation, UFS; Prof Gert van Zyl, Dean: Health Sciences; Dr Martin Nyaga, Senior Lecturer in the NGS Unit; Prof Joyce Tsoka-Gwegweni, Vice-Dean: Health Sciences; Dr Glen Taylor, Senior Director: Research and Development; Prof Jeffrey Mphahlele, Vice-President, South African Medical Research Council.

The inaugural edition of the University of the Free State (UFS) Next-Generation Sequencing (NGS) Data and Bioinformatics Workshop, hosted by the UFS-NGS Unit in the UFS Faculty of Health Sciences, marked a new beginning for the advancement of NGS in Africa under the auspices of the African Enteric Viruses Genome Initiative (AEVGI), which was recently funded by the Bill and Melinda Gates Foundation.

The AEVGI will generate rotavirus genomes at the UFS-NGS Unit to investigate the long-term effects of the introduction of the monovalent RV1 vaccine in three African countries – Ghana, Malawi, and South Africa.

The workshop attracted over 90 participants from 15 national and international institutions, with organisations from seven different countries as well as company representatives attending the event. The workshop kicked off with a courtesy call to the Rector and Vice-Chancellor, Prof Francis Petersen, followed by a stakeholder meeting with the executive management of the UFS.

The funding was secured through an award to the principal investigator, Dr Martin Nyaga, and sub-awards to co-investigators, Dr Khuzwayo Jere, Dr Francis Dennis, and Dr Valentine Ndze. According to attendee evaluations of the workshop, the remarkable performance of the workshop instructors was outstanding. Through practical sessions, participants were equipped with knowledge on how to apply several tools of genetic data analysis, using the rotavirus genome as a model to construct and interpret different genomic datasets.

A total of 65 students attended the hands-on workshop, the majority of which were from South African higher-education institutions. The organisers are grateful to the sponsors, particularly to the Bill and Melinda Gates Foundation and the University of the Free State, for making the workshop a success. Whitehead Scientific and the South African Medical Research Council also played a major role in the success of the workshop. The local organising committee consisted of Dr Martin Nyaga (host, convener and chair), Dr Saheed Sabiu (secretary), and Mr Stephanus Riekert (principal ICT support).

News Archive

New Division of Virology to deliver crucial services for HIV diagnosis and resistance testing
2015-12-14

The establishment of a Division of Virology within the Department of Medical Microbiology, under the joint auspices of the UFS and the National Health Laboratory Service (NHLS), reflects the continued growth within Virology.  Dr Dominique Goedhals, Head of the Division, says the division will also provide training of undergraduate medical students, medical technologists and technicians, and registrars.

The newly established Division of Virology at the University of the Free State will be one of only five laboratories in the country to be involved in crucial diagnostic and testing services for HIV viral load monitoring, early infant diagnosis, and HIV resistance testing.

The Virology Diagnostic Laboratory serves as the reference laboratory for all HIV National Priority Programme samples for the Free State and Northern Cape provinces.

Medical staff at the laboratory will provide a 24-hour consultative service, as well as outreach programmes to district laboratories in the Free State and Northern Cape where pathologists are not available. 

Dr Dominique Goedhals, Head of the Division of Virology, says this division, under the joint auspices of the UFS and the National Health Laboratory Service (NHLS), reflects the continued growth within Virology.

The division will not only deliver this critical diagnostic service, but will also focus on training and teaching, as well as research.

Teaching and training activities include teaching of undergraduate medical students, medical technologists and technicians, and registrars.  The postgraduate science programme has a high output of honours, master’s and doctoral students in Virology.  The intern medical scientist programme is also active, with five interns having successfully submitted their portfolios since the programme was implemented in 2010.

Research activities under the Head of Research, Prof Felicity Burt, have also expanded and continue to show increases in publication output and acquisition of grant funding.  Established research groups within the Division of Virology focus on vector-borne and zoonotic viruses, human papilloma viruses (HPV), and human immunodeficiency virus (HIV), as well as work with a number of international collaborators.


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