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19 July 2018 Photo Supplied
AEVGI advances Next-Generation Sequencing in Africa
Prof George Armah, Noguchi Memorial Institute for Medical Research, Ghana; Prof Carl Kirkwood, Bill and Melinda Gates Foundation, USA; Cornelius Hagenmeier, Director: Internationalisation, UFS; Prof Gert van Zyl, Dean: Health Sciences; Dr Martin Nyaga, Senior Lecturer in the NGS Unit; Prof Joyce Tsoka-Gwegweni, Vice-Dean: Health Sciences; Dr Glen Taylor, Senior Director: Research and Development; Prof Jeffrey Mphahlele, Vice-President, South African Medical Research Council.

The inaugural edition of the University of the Free State (UFS) Next-Generation Sequencing (NGS) Data and Bioinformatics Workshop, hosted by the UFS-NGS Unit in the UFS Faculty of Health Sciences, marked a new beginning for the advancement of NGS in Africa under the auspices of the African Enteric Viruses Genome Initiative (AEVGI), which was recently funded by the Bill and Melinda Gates Foundation.

The AEVGI will generate rotavirus genomes at the UFS-NGS Unit to investigate the long-term effects of the introduction of the monovalent RV1 vaccine in three African countries – Ghana, Malawi, and South Africa.

The workshop attracted over 90 participants from 15 national and international institutions, with organisations from seven different countries as well as company representatives attending the event. The workshop kicked off with a courtesy call to the Rector and Vice-Chancellor, Prof Francis Petersen, followed by a stakeholder meeting with the executive management of the UFS.

The funding was secured through an award to the principal investigator, Dr Martin Nyaga, and sub-awards to co-investigators, Dr Khuzwayo Jere, Dr Francis Dennis, and Dr Valentine Ndze. According to attendee evaluations of the workshop, the remarkable performance of the workshop instructors was outstanding. Through practical sessions, participants were equipped with knowledge on how to apply several tools of genetic data analysis, using the rotavirus genome as a model to construct and interpret different genomic datasets.

A total of 65 students attended the hands-on workshop, the majority of which were from South African higher-education institutions. The organisers are grateful to the sponsors, particularly to the Bill and Melinda Gates Foundation and the University of the Free State, for making the workshop a success. Whitehead Scientific and the South African Medical Research Council also played a major role in the success of the workshop. The local organising committee consisted of Dr Martin Nyaga (host, convener and chair), Dr Saheed Sabiu (secretary), and Mr Stephanus Riekert (principal ICT support).

News Archive

Care centre goes high-tech to help sexual abuse victims
2016-11-25

Description: Colposcope Tags: Colposcope

The colposcope, donated by the Discovery Fund,
will be used during gynaecological examinations
to detect any irregularities.
Photo: Supplied

Rape is one of South Africa’s most pressing social problems. Rape levels in the country are often discussed and reported on, but it does not deter perpetrators from this behaviour. According to Africa Check, of the more than 42 000 rape cases reported in 2015, 15 790 were child rape cases.

In an effort to assist victims of sexual assault and rape, the University of the Free State (UFS) Department of Family Medicine adopted the Tshepong Thuthuzela Care Centre, under the leadership of UFS lecturer Dr Mariaan Kotze.

The Discovery Fund donated a colposcope to Tshepong Thuthuzela Care Centre, an instrument that works with the help of a bright light and which is used to examine victims of abuse. It has also become a standard of good practice in the assessment of child abuse worldwide. According to Dr Kotze, the new instrument will also be used for training health practitioners by rendering clinical forensic services to abuse victims.

Managing complex issues

The care centre works with between 80 and 120 victims of rape each month, a third of whom are children under 14 years of age. According to Dr Kotze, the management of child sexual abuse victims is more complex than with adults; as there is a higher chance of missing or over-diagnosing abnormalities. Also, she says, the examination process is often observed by a group of healthcare practitioners, an experience which is often intrusive and intimidating for the child. With the colposcope, the timeframe of the examination is shortened, and can be captured and viewed in real time, without the victim being present.

Best care for victims

The colposcope is a magnifier and light source used during gynaecological examinations. It is instrumental in providing the best care to victims of sexual abuse, and helps diagnose and assist in the treatment of cases of abuse. Its ability to capture and review images at the time of examination allows for retrospective research, and improves the ability of expert witnesses in court cases.

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