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20 March 2018 Photo Charl Devenish
Town and Gown programme to expand university reach in communities
Prof Petersen signs an MOU with Princess Motshabi Moroka, patron of the Princess Gabo Foundation, at the launch of the Town and Gown programme.
The University of the Free State (UFS), through the office of Community Engagement, launched the Town and Gown programme on 13 March 2018 at the Bloemfontein Campus. The programme seeks to demonstrate the university’s commitment to building sustainable partnerships in communities and its surrounding towns. It aims to be integrally involved in addressing societal challenges, as well as to avail its intellectual and academic resources to partner with civic and religious organisations, government entities and business communities.

Engaged scholarship central to institutional strategy
In his welcoming remarks, Prof Nicky Morgan Acting Vice Rector: Institutional Change and Student Affairs, said: “The university is not complete without its community and in the same way the community should benefit from the university. This has been encompassed in the newly launched Integrated Transformation Plan (ITP) which has community engagement as one of its components.”  The event was attended by representatives of the Mangaung Metropolitan Municipality, NGOs, religious and traditional leaders, student structures and UFS staff members.

Prof Francis Petersen: Rector and Vice Chancellor, said the university ought to articulate community engagement differently from what other organisations would do, by showcasing engaged scholarship and using teaching and research to make a difference. He emphasised the importance of being close enough to communities to be able to ascertain their needs in such a way that the component of community is brought into the classroom and in the university’s research.

Expansion of community outreach under way
The long-standing ties between the university and communities in the Free State span many years, during which time various collaborative projects have been established with, among others, Non Profit Organisations (NPOs), such as Bloemshelter, faith-based organisations, and traditional leadership structures.

To date, the UFS has supported programmes in education, health, law and rural development through service-learning programmes, involving students and academics in various fields. The target of the Town and Gown programme is to reach out further to include new partnerships in the Motheo Metro Municipality, Maluti-a-Phofung District Municipality, and Kopanong Local Municipality.

Long-standing partnerships strengthened
At the event, several memoranda of understanding (MOU) were signed to confirm five-year collaborative agreements between the university and partner organisations, one of which is the Princess Gabo Foundation based in Thaba Nchu. Bishop Billyboy Ramahlele, Director: Community Engagement said that the MOUs would strengthen partnership with the communities in research, community service learning, and volunteer programmes.

The Town and Gown initiative is a step taken to re-affirm the university’s commitment to partnering with stakeholders in strengthening the capacity of surrounding towns, metros and the Free State region as a whole.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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