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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology

The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

Community Service Summit
2008-10-20

Community service must heal our campus

Photo gallery

Community service and community service learning at the University of the Free State must be put in the forefront of healing our divided campus and our divided country.
This was the message from the Acting Rector Prof Teuns Verschoor when he opened the Community Service Summit that was held in Thaba Nchu on 9 and 10 October 2008.
“The importance of community service is that it heals those who help others because the needs of others are more important than our own needs when we render service to those who are worse off than ourselves,” prof Teuns said.

He said community service has already helped to change the UFS in terms of the academic experience of students and staff and in terms of the perceptions that various communities hold about the UFS.

The summit was attended by more than 35 representatives from different Faculties and departments of the university, representatives from the communities in the Motheo and Xhariep District Municipalities as well as the project managers of Lebone Land and the Bloemfontein Life Change Centre.

Several issues pertaining to the Community Service Policy of the UFS, as well as other related issues were discussed which will culminate in a Statement of Intent that will be handed to the Executive Management of the UFS. This is being done in response to the challenge of the acting rector that the Summit will make a meaningful input in the repositioning process of the UFS.

One delegate described her participation in the Summit as a life changing experience. “This articulation of her experience has captured the views of a lot of the delegates. It shows that there is a big need to cement the importance, commitment to and implementation of Community Service and Community Service Learning at the University of the Free State. With the support of our partners we are determined to make a difference in the lives of the people of the Free State and beyond,” said Rev Kiepie Jaftha, Chief Director Community Service at the university.



 

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