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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology


The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

Active citizenship key to building healthier communities
2014-09-22

Photo: Mamosa Makaya

The Office of Community Engagement in collaboration with Bloem Shelter, hosted a three-day Indaba on active citizenship. The focus of the event was to engage local government leaders, NGOs and social services groups on creating a society that is healthier, safer and more informed.

The over-arching theme of the Indaba centred on the strengthening of family structures, social and health service delivery, spiritual healing and counselling. Amongst the various speakers was Rev Jennifer Samdaan, Minister in the Methodist Church and community activist. During her presentation, ‘Youth, Women and Children at Risk in South Africa', she highlighted the challenges that women and youth in townships and rural areas deal with in their daily lives. One example is physical and sexual violence while commuting to school and work. Rev Samdaan’s organisation has been instrumental in engaging municipal authorities in the region of Kokstad to provide security and lighting on roads where women are most vulnerable to violent attacks as they commute from work.

Community workers discussed their contributions in the fields of marital and family counselling and mental health support services. They discussed the benefits of their collaboration with local judicial bodies and other community leaders to render services to victims of domestic violence.

Rev Billyboy Ramahlele, Director in the Office of Community Engagement, emphasised the role of leadership and the responsibility of political leaders and citizens alike to ensure accountability in the quest to build a healthier society.

Vanessa Booysen, a neonatal consultant for Newborn Care in South Africa, demonstrated the importance of bonding between mothers and their babies. She called attention to the negative effects on the development of babies when separated from their mothers and the future challenges this causes. Modern medicine also leads to fewer women giving birth naturally. Booysen stressed that "it matters how we are born". She encouraged health practitioners to go back to basics in maternal care to lessen the negative effects that pass onto children into adulthood.

The workshop concluded with an exhibition by various groups that showcased the information resources and services offered to communities in the Free State.

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