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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology

The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

Expansion to Physics building officially opened on Bloemfontein Campus
2016-05-06

Description: New Physics building Tags: New Physics building

The newly-opened addition to the Physics Building on the Bloemfontein Campus.
Photo: Charl Devenish

An extension to the Department of Physics at the University of the Free State (UFS) was officially opened on the Bloemfontein Campus on 20 April 2016.

“This started off about five years ago when we were talking about not having enough room for large classes. Prof Matie Hoffman suggested that we build a large lecture room on our parking space,” said Prof Hendrik Swart, Professor in the Department of Physics as he addressed guests at the official opening ceremony.

“A year later, we received a Sarchi Research Chair [South African Research Chairs Initiative] on Advanced and Luminescent Materials. We needed more office and laboratory space. The two ideas were combined and presented to the university’s senior management,” he added.

When the university was founded in 1904, Prof James Lyle was appointed to head up the Physics and Chemistry departments. Five years later, a single room was allocated for the Physics laboratory in the main building upon its completion. In 1947, the old Physics building was designed and constructed. Fast forward 69 years, the department has reached another milestone. Facilities accommodated by the expansion include a new telescope for astrophysics experiments, a basement for storing old equipment, as well as a sliding trap door which allows heavy goods to be elevated into the building from the ground floor. The telescope is one of the many unique features of the building given its capacity to expose graduate students to the basic techniques of radio astronomy, especially in light of the fact that the SKA (Square Kilometre Array) project which is in progress.

“Our department is extremely strong at this stage, and a bright future lies ahead,” said Prof Koos Terblans, the Head of Department. The opening also served to celebrate the 103 publications achieved by the department last year.

Dr Lis Lange, Vice-Rector: Academic is proud of the heights reached by the department to date. “The Department of Physics is undoubtedly one of the jewels in the crown of our university, and we are very proud of its developments. Universities are built on legacies, and they are also about change, which is what this department has been demonstrating.”

The expansions to the building with its top-class facilities, was constructed at a cost of R25 million – an infrastructure grant courtesy of the Department of Higher Education and Training.

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