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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology


The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

KovsieFit caters for all
2016-05-30


KovsieFit offers a new service to students and staff for keeping fit. Photo: Charl Devenish

Students on the Bloemfontein Campus of the University of the Free State (UFS) can now work in a gym session between classes, and staff can do the same before or after work.

This is due to KovsieFit, a commercial gymnasium, which will be taking in its first members on 30 May 2016. The gym is located in the Callie Human Centre and is a project which has been a long-time dream for the UFS.

UFS boasts three gymnasiums

For the last couple of months, a lot of hard work went on behind the scenes. Kobus Calldo, conditioning coach at KovsieSport, says everybody involved with the process is happy that KovsieFit is a reality. According to him KovsieFit “is looking good and everybody involved is very satisfied” with the final product.

KovsieFit will be open Mondays to Fridays from 05:30 to 19:30, and on Saturdays from 07:00 to 11:00. Prospective members will have to undergo health screenings before they may join. KovsieFit also has lockers available. The gym will be managed by a committee.

The High Performance Centre of the UFS, where athletes and sports teams are training, is located next to KovsieFit. At the beginning of the year, KovsieSport’s offices also moved to the Callie Human Centre. A third gymnasium, the Sports Science Centre – the former Biokinetics gymnasium – is located next to the Mabaleng Building. This will mainly be used as a rehabilitation centre.

Service to university community

According to Calldo KovsieFit caters for all and offers the same service to its members as any other commercial gymnasium. The target mark is primarily students and staff, and then the rest of the city.

“It is cheaper and conveniently close to the residences for students on campus. Staff members can have a gym session during lunch or before or after work.”

Wide variety of exercises

“We offer spinning, pilates, aerobic, zumba, and all those type of classes too. We will start with four classes a day until business picks up,” Calldo says.

KovsieFit also offers aerobic apparatus such as treadmills, rowers, and electric bicycles. A gymnasium circuit, two Olympic platforms, and different types of weights and machines are also available.

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