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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology


The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

Bright young mind shines
2016-12-12

Description:Candice Thikeson  Tags: Bowls  longdesc=


Candice Thikeson, a Master’s
student in Arts History and
Image Studies at the University
of the Free State.
Photo: Anja Aucamp

“I was once told that I looked ‘immaculate’, as always. We use the word ‘immaculate’ to describe the Virgin Mary, does it get better than that?”

To everyone else, she may be a Mandela Rhodes Scholar, Bright Young Mind and Abe Bailey Travel Bursary candidate, but there is more to this beauty that meets the eye.

Relating to women in the humanities field

Candice Thikeson, who is currently a Master’s student in Art History and Image Studies, says “I have a very strong spiritual foundation and my relationship with God really fuels everything I do. I also think being intentional about building great relationships with your family and friends is imperative.”

She says she has been inspired by different people at different stages of her life and draws a great deal from academics, creatives and activists. She relates best to women who are in the humanities and draws inspiration from the likes of Nigerian novelist, Chimamanda Ngozi Adichie, and Kenya-born, Somalian poet Warsan Shire.

“I love how they are able to comment on some of the most pressing issues black women face through beautiful and poignant writing. I also admire how frank these women are, something I’m still learning to be,” Thikeson says.

Pursue something you are genuinely interested in

The biggest misconception people have of her is that she studies art and she is working towards becoming an artist. “Fine art and art history is not the same thing. I don’t paint or make art at university, and I really don’t enjoy being called an artist.”

When asked about how she has become so successful at such a young age, she reiterated the cliché: “pursue something you are genuinely interested in and passionate about”. She adds, “if you are really good at what you do, your gift will make room for you in your field”.

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