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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology


The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

UFS study shows playing time in Super Rugby matches decreasing
2016-12-19

Description: Super Rugby playing time Tags: Super Rugby playing time 

The study by Riaan Schoeman, (left), Prof Robert Schall,
and Prof Derik Coetzee from the University of the Free State
on variables in Super Rugby can provide coaches with
insight on how to approach the game.
Photo: Anja Aucamp

It is better for Super Rugby teams not to have the ball, which also leads to reduced overall playing time in matches.

This observation is from a study by the University of the Free State on the difference between winning and losing teams. Statistics between 2011 and 2015 show that Super Rugby winning teams kick more and their defence is better.

These statistics were applied by Riaan Schoeman, lecturer in Exercise and Sport Sciences, Prof Derik Coetzee, Head of Department: Exercise and Sport Sciences, and Prof Robert Schall, Department of Mathematics and Actuarial Sciences. The purpose of the study, Changes in match variables for winning and losing teams in Super Rugby from 2011 to 2015, was to observe changes. Data on 30 games (four from each team) per season, supplied by the Cheetahs via Verusco TryMaker Pro, were used.

About two minutes less action
“We found that the playing time has decreased. This is the time the ball is in play during 80 minutes,” says Schoeman. In 2011, the average playing time was 34.12 minutes and in 2015 it was 31.95.

“The winning team has less possession of the ball and doesn’t want it. They play more conservatively. They dominate with kicks and then they play,” says Prof Coetzee, who was the conditioning coach for the Springboks in 2007 when they won the World Cup.

Lineouts also more about kicking
As a result, the number of line-outs also increased (from 0.31 per minute in 2011 to 0.34 in 2015) and the winning teams are better in this regard.

“The winning team has less possession of the ball
and doesn’t want it. They play a more conservative
game. They dominate with kicks and then they play.”

Schoeman believes that rule changes could also have contributed to reduced playing time, since something like scrum work nowadays causes more problems. “When a scrum falls, the time thereafter is not playing time.”

According to Prof Coetzee, rucks and mauls have also increased, (rucks from 2.08 per minute in 2011 to 2.16 in 2015 and mauls from 0.07 per minute in 2011 to 0.10 in 2015). “The teams that win, dominate these areas,” he says.

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