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17 September 2018 Photo Charl Devenish
Science Its a girl thing
Innocensia Mangoato’s research on using cannabis to reverse anticancer drug resistance has been awarded in the prestigious Women in Science Awards.


“There’s this misconception among young people that science is difficult and that it’s somehow a man’s domain,” says Innocensia Mangoato, Masters student in Pharmacology, who has just been awarded in the prestigious Women in Science Awards by the Department of Science and Technology.

Cannabis research

Innocensia won in the Master’s Degree category for her research on the use of cannabis in reversing anticancer drug resistance. Her department had to apply for a special permit to grow cannabis for research and medicinal purposes.

“Her findings have already indicated a promising reversal of resistance to drugs in a variety of cancers. We plan to explore these results further in a possible PhD,” says her study leader, Prof Motlalepula Matsabisa.

Innocensia says she’s always had an interest in science, and initially wanted to study medicine. She ended up doing a BSc in Physiology and Genetics.

She hopes that her research will help government to develop a policy around the use of cannabis for medicinal purposes which could ultimately lead to developing cancer treatment with fewer side-effects.

Female mentors

“My mentor during my Honours studies was Dr Makhotso Lekhoa. Her passion for her field and her patience in conveying it to others really inspired me. We have some very powerful women in our Pharmacology Department,” says Innocensia.

Passion for science 

“You know you’re passionate about your work when you find yourself going to the lab on Sunday afternoons!” she says. “I’m happy that I can be contributing to the knowledge production on this campus. And maybe one day I can be a mentor to other girls with that same passion for science.”

News Archive

UFS cardiac team leading with project
2017-05-31

 Description: Cardiac team read more Tags: Cardiac team read more

Prof Peter Schultheiss of the Charité University in Berlin,
Germany, visited the Robert WM Frater Centre for
Cardiovascular Research at the UFS for a study regarding
cardiomyopathy, a significant cause of fatal heart failure
among Africans. From the left are Dr Glen Taylor,
Dr Danie Buys, Prof Makoali Makatoko,
Prof Schultheiss and Prof Francis Smit.
Photo: Rulanzen Martin

A team of cardiac doctors associated with the Robert WM Frater Cardiovascular Research Centre at the University of the Free State’s (UFS) Faculty of Health Sciences has commenced with a pioneering research project regarding idiopathic dilating cardiomyopathy.  

An Afrocentric research focus
Prof Francis Smit, Head of the Department of Cardiothoracic Surgery at the UFS and Head of the Frater Centre, describes dilating cardiomyopathy as a heart muscle disease that is quite common, particularly among people of African descent. The disease weakens the heart muscle, which in turn leads to heart failure.

“To date there is no curable treatment for this condition and 50% of patients that have shown heart failure, died within a period of five years. The causes of this condition have been unknown in the majority of patients. But over the past few years major strides have been made where virus infections of the heart muscle or myocarditis have been identified as a possible underlying cause. Various genetic diseases are also linked to it,” says Prof Smit.

International collaborations ensure success
According to Prof Smit, the project is being run in conjunction with Prof Heinz-Peter Schultheiss of the Charité University and the Institute for Cardiac Diagnostics and Therapy in Berlin, Germany.

“We have been working on the project over the past 18 months and I have twice visited Prof Schultheiss in Germany. He is now visiting us in Bloemfontein. We have established a collaborative project focused on patients in central South Africa”.
Prof Schultheiss is a world leader regarding the diagnosis, pathology and treatment of dilating cardiomyopathy, says Prof Smit.

“He brings a lifetime of research experience to Bloemfontein and is internationally renowned as the father of myocardial or heart muscle biopsies.

“His pioneering work on the discipline has led to diagnostic accuracy that has induced purposeful and personalised treatment of dilating cardiomyopathy and has brought about dramatic changes in some subsets of patients’ life expectancy and their cure.”

Solving problems close to home
According to Prof Mokoali Makatoko, Head of the Department of Cardiology, there are more than 1500 new cases of heart failure identified annually at the Universitas Academic Hospital, of which approximately 30% are attributed to cardiomyopathy. “With the use of endomyocardial biopsies the team hopes to treat viruses unique to Southern Africa as well as other underlying causes of dilating cardiomyopathy.”

Prof Stephen Brown, Head of Paediatric Cardiology at the Universitas Academic Hospital, says children suffering from this disease never reach a mature age and those under his supervision will also be undergoing these tests. Various other departments at the UFS will also participate in this project. Profs Makatoko and Brown did the first four endomyocardial biopsies under the management of Prof Schultheiss during the past week. The results will be available in the coming weeks after which the project will be officially launched and patient recruitment will start in earnest.

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