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30 October 2019 | Story Rulanzen Martin | Photo Rulanzen Martin
Prof Jacobus Naude
Prof Jacobus Naudè is one of few South Africans who have delivered the Van Selms Memorial lecture at the Southern African Society Near Eastern Studies conference.

To be awarded an opportunity to present a lecture outside the domain of your own university is not only beneficial to attract new postgraduate students but also provides senior researchers with the opportunity to publicise their research on a national and sometimes international level.

This is the impression of Prof Jacobus Naudè, a senior professor in the Department of Hebrew at the University of the Free State (UFS) when he delivered the 2019 Adrianus van Selms Memorial lecture at the Southern African Society for Near Eastern Studies conference. Prof Naudè said such lectures provide an opportunity to academics and researchers to demonstrate that a particular field of study has broad implications for society. “A South African only has the opportunity to deliver this lecture every second year by invitation, so it’s a once-in-a-lifetime opportunity,” he said. 

His own research seeks to understand alterity (“otherness”) in various systems of ancient culture and to preserve it while representing it intelligibly for modern users. “In my current research I utilise complexity theory to integrate seemingly disparate foci (pre-modern Hebrew linguistics and religious translation).” 

The conference took place on 16 September 2019 at the School of Religion, Philosophy and Classics at the Pietermaritzburg Campus of the University of KwaZulu-Natal.

South African Bible translations through the ages

The topic of his lecture was, Translations of sacred texts and the shaping, reshaping and circulation of religious knowledge in monotheistic religions with written traditions: A Southern African perspective, in which he provided examples from the history of religious translations in monotheistic religions (Jewish religious tradition, Christianity and Islam) to “illustrate the spreading, circulation, shaping and reshaping of our religious knowledge by translation”.  

Prof Naudè shared some aspects of how religious ideas have travelled via the medium of translation into different cultures and languages. With his focus on South Africa he illustrated how the Dutch East India Company imposed monolingualism in the Cape with Dutch being the only language in church and at school. “There was complete unwillingness on the side of the Dutch to learn the Khoikhoi languages.” The political change in beginning of the 19th century provided strong motivation for Bible translations into indigenous languages. 

There have been many attempts to reconceptualise South African translations of the Bible. The latest attempt was by Prof Kobus Marais from the UFS Department of Linguistics and Language Practice whose work aims to reconceptualise translation within the frame of complexity thinking. “Religious translation will thus need to avoid reductionism and rather focus on the source or the target,” Prof Naudè said.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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