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17 January 2020 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Prof Aliza le Roux and Dr Mpho Romoejane
Prof Aliza le Roux and Dr Mpho Ramoejane (camera-trap expert) at a wetland area in the Golden Gate National Park, searching for the rare white-winged flufftail.

The White-winged Flufftail, a highly endangered bird species, was spotted less than 70 km from the UFS Qwaqwa Campus, home of the Afromontane Research Unit (ARU). In collaboration with BirdLife South Africa, the ARU is conducting a study to find out if this species also made its home in the Golden Gate Highlands National Park.

This rare species has so far only been found at three sites in South Africa.


Study to benefit local community

One of the ARU’s goals is to undertake research that will benefit the local communities, including SANParks. Should it be confirmed that these rare birds are also found in the area, the status of the Golden Gate Highlands National Park in the Important Birding Area (IBA) directory is likely to increase.

Prof Aliza le Roux, Associate Professor in the Department of Zoology and Entomology on the Qwaqwa Campus of the University of the Free State (UFS) and affiliated to the ARU, is conducting the study. She is also involved in other wetland studies.

According to Prof Le Roux, it is very difficult to find the bird. In a study, Prof Le Roux, Dr Sandy-Lynn Steenhuisen (botanist in the Department of Plant Sciences), and Dr Ralph Clark (ARU Director) have been deploying song meters in a rolling grid in the wetland areas, recording all bird noises around dawn and dusk. This is a non-invasive method to record bird sounds and helps to maintain the health of wetlands.

With these song meters they are trying to create a soundscape of the wetlands, recording all the sounds of the area by changing the location of the song meters every two weeks to cover the entire 2 km-long wetland area. Soundscape ecology is a fairly new technique and could be an effective way of measuring wetland health in high-altitude settings.

“In contrast with camera traps, song meters do not need a direct line of sight to record the presence of a specific bird – it can pick up songs from 150 m away in all directions. Camera traps may, however, be useful for adding visual confirmation of any bird’s presence, which is useful for a species that has only been heard a few times. In fact, no recording of the White-winged Flufftail’s call is currently in the public domain,” says Dr Le Roux.


Collaboration with Japanese university

Using these recordings from the soundscape, the team identifies the different bird, frog, and insect sounds recorded. According to Prof Le Roux, they are fairly new to the process and she would like to learn more, specifically about the analysis of the song diversity. She is visiting researchers at the Okinawa Institute of Science and Technology (OIST) in Japan in early December to investigate the variety of tools available to effectively analyse terabytes of acoustic data. Researchers at OIST have done similar studies on soundscapes in Okinawa along an urban gradient, and their expertise as well as access to a supercomputer could boost this research significantly.

The Qwaqwa area is on the border of the White-winged Flufftail’s expected distribution range.

“Because they and their habitat are threatened,
we are not sure if they are in the area;
and whether they may only be here to breed.”
—Prof Aliza Le Roux,
Associate Professor, UFS.


“If we find that they did make the park their home, they will be more protected, as the park is a conservation area.”


Grasslands

Prof Aliza le Roux and Dr Mpho Ramoejane (camera-trap expert) at a wetland area in the Golden Gate National Park. The wetlands often get trampled, affecting the condition of the area. Interestingly, trampling improves conditions for flufftails, as the cattle open up spaces between the reeds.

Photo: Leonie Bolleurs

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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