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24 November 2020 | Story Andre Damons
Prof Gert van Zyl, Dean of the Faculty of Health Sciences, presented a copy of the book to Prof Francis Petersen, UFS Rector and Vice-Chancellor.

Looking at the history and highlights of the Faculty of Health Sciences at the University of the Free State (UFS) you will find a golden thread of innovation running throughout. The faculty has not been afraid of the unknown and its focus has always been on patients and quality academic education.

This is according to Prof Gert van Zyl, Dean of the faculty, who gave an overview at the virtual launch of the book: The History of the Faculty of Health Sciences: 2004 – 2020 on Tuesday (17 October 2020). Prof Johan Diedericks, Emeritus Professor in the Dean’s office, is the author of the book.

This book launch was part of the faculty’s 50-year anniversary celebrations.

A two-year journey

Prof Diedericks said the journey to materialising the book started two years ago when Prof Van Zyl “coaxed” him into compiling it. “At that stage I was writing the history of the Department of Anesthesiology and still had a 6/8 clinical appointment which meant I only had one day a week free to work on the book.

“But it was time well-spent. It started off with reading a lot of minutes and annual reports but at the same, time I requested and begged (but did not threaten) the departments for information. That was quite difficult. Several people assisted me in getting the information but the material came in slowly” said Prof Diedericks.

There was also cooperation from all the heads of schools who eventually made sure he got the information he needed. He wrote some of the sections himself and also edited and re-wrote parts of the information he received to ensure everything is the same format.

The book consists of eight chapters and five appendices with graphs and statistics. Chapter one is an overview of the changes since 2004 the present day and chapter two is about the office of the dean followed by the five schools in the faculty and all the departments within the schools.  The last chapter has information on other sections such as the Frik Scott Medical Library, National Health Laboratory Service, the SA Doping Control Laboratory (SADoCoL) and student organisations.

Faculty highlights

Prof Van Zyl said he was sure the experiences learnt from the past 50 years had prepared the faculty to survive 2020 – the year of COVID-19. In his overview, he spoke about the human contribution.

“The human contribution is the mortar between the bricks of this faculty, our staff and students not just today, but over 50 years. Looking at the history of the faculty and reflecting back, it was built by the collective and individual efforts of women and men in the faculty to ensure that each and every step is taken with integrity and quality to take us forward.”

He said he hopes this history will not only offer adequate information to appreciate the huge contribution that members of the Faculty of Health Sciences, the university community, and the entire Free State had made in health over the past 50 years.

Re-inventing yourself 

Prof Francis Petersen, UFS Rector and Vice-Chancellor, who received a copy of the book from Prof van Zyl, had a message to every one attending the virtual event: “If you don’t understand your history, where you come from, it is very difficult to know where you are going.

“In a learning environment such as the university, we always have to renew ourselves and you can renew yourself through what is happening in your current environment, through what happened in your history and also through what is happening in innovation going forward. I think that is the message captured in this book.

“There are various re-inventions that happened over this period and we should continue with that going forward as members of the faculty, as students, and as alumni of the faculty. The faculty can even go far beyond where it is at the moment. But we must remember we are standing on the shoulders of individuals who made major contributions, not only to the faculty, but to the province, to the country and internationally. We have a duty and responsibility to build on that and I know the faculty is doing that,” concluded Prof Petersen.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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