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30 October 2020 | Story Leonie Bolleurs

The Department of Science and Technology has extended two of the National Research Foundation’s SARChI research chairs at the University of the Free State (UFS). 

The Research Chair in Diseases and Quality of Field Crops, together with the Research Chair in Vector-borne and Zoonotic Pathogens, have both been extended for another five years. 

Prof Maryke Labuschagne, currently Professor of Plant Breeding in the Department of Plant Sciences, is leading the chair on Diseases and Quality of Field Crops.

The Chair on Vector-borne and Zoonotic Pathogens is headed by Prof Felicity Burt from the Division of Virology in the Faculty of Health Sciences.

Prof Corli Witthuhn, Vice-Rector: Research, says it was the hard work and commitment of Profs Labuschagne and Burt that resulted in the extension of the SARChI research chairs. “They have excelled in terms of student supervision and publications in high-impact international journals.  They also serve as mentors for young academics, postdoctoral fellows, and colleagues through their passion for their different fields of interest.”

Prof Witthuhn believes that this extension of the two SARChI chairs speaks of the progress that the UFS has made in terms of developing itself as a research-led university. “We are proud of the two senior academics for their supervision, mentorship, and leadership and their contribution to building our reputation,” she says. 

Diseases and Quality of Field Crops

The focus of the research chair in Diseases and Quality of Field Crops is on advancing food security and nutrition in Africa and contributing to poverty reduction and achieving sustainability goals. 

Prof Labuschagne says despite recent advances, the headlines regarding hunger and food security remain alarming: one in nine people on earth will go to bed hungry every night. Globally, 800 million people do not have enough to eat to be healthy, and a third of all deaths among children under five in developing countries are linked to undernourishment. 

She believes the uniqueness and strength of the research chair lies in a two-pronged approach, namely the breeding of cereal crops for resistance to fungal diseases, and improving the quality of crops for processing and consumption, thus making an impact on food security in South Africa and the rest of Africa through this collaborative effort. 

She is confident that the extension of the research chair will allow them to continue and to expand their research, “which has built up a lot of momentum”.

Besides the 12 PhD and 8 MSc degrees they delivered in the first five years, they also contributed significant research outputs and cultivar releases. She adds that they would like to expand on the significant international collaboration they have established. 

Vector-borne and Zoonotic Pathogens

According to Prof Burt, the SARChI chair in Vector-borne and Zoonotic Pathogens builds on existing research strengths at the UFS and aims to contribute towards identifying and investigating medically significant arboviruses and zoonotic viruses in the country.
 
“To date, the research chair has facilitated progress towards establishing serosurveillance studies for various vector-borne viruses, specifically Crimean-Congo haemorrhagic fever virus, a tick-borne and zoonotic virus that causes severe disease with fatalities.”

The team of researchers operating within this research chair is currently also performing studies to determine the seroprevalence of severe acute respiratory coronavirus 2 (SARS-CoV-2) in the Free State.

Prof Burt has always taken the importance of community engagement into account, and with the current pandemic, she believes that it is now more important than ever to increase public awareness of zoonotic diseases.

She emphasises that the majority of new and emerging viruses are zoonotic in origin and that the current SARS-CoV-2 pandemic highlights the impact of an emerging zoonotic pathogen on society. Therefore, she feels that it is important to build capacity in this field and to focus research efforts on identifying and understanding where these pathogens cycle in nature, the potential for spill-over to humans, and what the drivers are for the emergence of these pathogens.

Prof Burt trusts that the renewal of the research chair will allow them to take advantage of the new biosafety laboratory that the UFS has invested in. “This will permit us to research pathogens that were previously excluded from our programme due to biosafety considerations.  The chair will furthermore contribute towards enhancing, strengthening, and developing research and knowledge in the field of epidemiology and pathogenesis of vector-borne and zoonotic viruses,” she says. 

News Archive

UFS to monitor the use of ARV-drugs on pregnant women and children
2004-12-08

The University of the Free State (UFS) is to establish a Pharmacovigilance Centre that will monitor the effects of Anti-Retroviral (ARV) drugs on HIV positive pregnant women and children starting early in the new year.

The UFS is one of only two institutions chosen by the Minister of Health, Dr Manto Tshabalala-Msimang, to establish such an ARV monitoring centre.

The other centre will be based at Medical University of South Africa (MEDUNSA) and will concentrate mainly on monitoring the effects of the drugs on adults.

“The establishment of the UFS’s Pharmaconvigilance Centre forms part of government’s Comprehensive Plan on HIV and AIDS, often termed the roll-out plan for ARV drugs. The centre’s primary responsibility will be to specifically monitor the use of these drugs in pregnant women, and children under the age of 13,” said Prof Andrew Walubo of the UFS’s Department of Pharmacology.

“Although most of the side effects of ARV drugs have been identified in other countries, it has now become critical to identify the side effects amongst the South African population. This is important because many people will be exposed to the drugs within a short time. Our aim is so identify the most common side effects and make recommendations for the prevention thereof. The centre will help in detecting the risk of using anti-retroviral drugs in pregnancy and children, and prevention of adverse drug reactions,” said Prof Walubo.

According to Prof Walubo 12 drugs will be monitored – these drugs will be selected according to the patient’s profile.

The centre will comprise of two components: A pregnancy registry, which will focus on a new-born child up until two months and a pediatric registry, which will focus on children who are born of mothers who used ARV drugs and children using ARV drugs.

According to Prof Walubo, the Pharmaconvigilance Centre will also be responsible for offering relevant technical advice, training and selected research on ARV drugs in these patients.

The centre will be fully sponsored by the national Department of Health. It will be based in the UFS’s Faculty of Health Sciences, Department of Pharmacology, and will be run in collaboration with experts from different departments in the faculty.

Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
8 December 2004

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