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10 September 2020 | Story Rulanzen Martin | Photo Mlungisi Louw
Dr Francois Smith wants his new book, Die kleinste ramp denkbaar, to be a journey to uncover the real disaster.

The new book by Dr Francois Smith from the Department of Afrikaans and Dutch, German and French, Die kleinste ramp denkbaar, is a compelling story about a medical doctor in a typical Free State town. Writing is second nature for Dr Smith, if not first – as evidenced by the success of his debut novel, Kamphoer.

“The success of my previous novel, Kamphoer, greatly contributed to the fact that I was able to get a job at the UFS, especially to teach creative writing,” says Dr Smith, who is currently a Lecturer in Afrikaans and Creative Writing at the University of the Free State (UFS). He does not want to divulge too much about the new book, but says “the story is about a medical doctor in a typical Free State town in whose consulting room a policeman is lying all but senseless from a high fever one morning.” 

The title of the book implies that we all have some kind of disaster fantasy and that the disaster mentioned in the book exists largely in the imagination of the main character – the doctor; that it is something he wants to see. “I am not going to reveal it completely, because in a sense the book is a search for what the disaster is really about,” says Dr Smith. 

For any author, the takeaway message of a book is important. It should touch the lifestyle of the reader in some way. Dr Smith wants Die kleinste ramp denkbaar to say something meaningful about life here in South Africa – “about what makes life here meaningful, or what it is that makes it possible for us to live in the midst of what we experience as a total disaster.” 


Creative Writing a UFS success story

Creative Writing, presented by the Department of Afrikaans and Dutch, German and French, is one of the many success stories that the department is proud of. Dr Smith is part of the formidable team driving the course; also part of the team is Prof Henning Pieterse, a Hertzog Prize-winning poet. 

The success of the course is not only evident from the number of applications, but also from the stream of publications from their stable.  “There will be three this year; in addition to mine, there was also the collection of short stories, Luistervink, by Madré Marais, and later this year Anton Roodt’s novel, Weerlose meganika, will be published,” says Dr Smith.



Die kleinste ramp denkbaar was published by Tafelberg Publishers and is part of the many success stories of the department’s Creative Writing course. 

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News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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