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20 April 2021 | Story Cornelius Hagenmeier

On 25 May 2021, Africa will celebrate the 58th anniversary of the founding of the Organisation of African Unity (OAU). A central tenet of the organisation, which was the predecessor of the African Union (AU), is African solidarity. This call celebrates the idea and the ideal of African solidarity. As we are preparing for Africa Month 2021, we received the shocking news about the damage to the University of Cape Town’s African Studies collection. The need for African solidarity to mitigate this immense loss has inspired the theme of the 2021 UFS virtual Africa Month celebration, ‘solidarity in knowledge production and recording’.

From the establishment of the OAU and with the later formation of the AU, member states undertook to coordinate and intensify their cooperation and efforts to achieve a better life for the people of Africa.

Africa Day Memorial Lecture

The UFS has a long tradition of commemorating Africa Day and the ideas underpinning it. Every year, diverse events aimed at advancing African unity and solidarity take place during Africa Month –traditionally, the highlight is the Africa Day Memorial Lecture hosted by the University's Centre for Gender and Africa Studies. On 19 May 2021 at 19:00 (SAST), Prof Walter D Mignolo, a guru of decoloniality, will virtually deliver this year’s lecture titled The beauty of the sovereign people: Jean Casimir and the Decolonial History of Haiti, to honour the memory of transatlantic slavery by reflecting on former ambassador, Prof Jean Casimir, who has shifted the geography of reasoning by breaking the code of the standard history of the slave trade, the African diaspora in the Caribbean, and of captive human beings in the plantations. The discussant will be CGAS Extraordinary Professor and Professor of Epistemologies of the Global South at the University of Bayreuth, Prof Sabelo J Ndlovu-Gatsheni.  

As COVID-19 continues to ravage the world, Africans have been fighting against the pandemic in various ways and have achieved considerable success in this regard. Given the economic and social challenges associated with the pandemic, fostering African solidarity and further developing the underpinning philosophy of ubuntu appear to be particularly worthwhile projects.

A virtual celebration of Africa Month

The UFS 2021 Africa Month commemorations will again take a virtual format. It will include a focus on UFS engagement on the continent, partnerships with other African institutions, research excellence, and student success stories.  The UFS invites all members of its community to contribute thought-provoking pieces to this virtual celebration of Africa Month. Selected contributions will be presented on the university's website and social media.

Among other formats, contributions may take the format of

  • recorded performing art performances (e.g., solo music or poetry);
  • virtual visual art presentations;
  • written poetry;
  • songs;
  • short thought/opinion pieces, which can also be published in mainstream media; or
  • topical academic writings.

Please share a brief written proposal explaining your planned contribution by 30 April 2021. The proposal should not exceed 300 words and should be emailed to Cornelius Hagenmeier (hagenmeiercca@ufs.ac.za) or Prof Colin Chasi (ChasiCT@ufs.ac.za).

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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