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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

UFS Centenary 2004/05: Sports Festival
2004-05-07

Win or lose! It is part of sportsmanship. The Kovsie Sports Festival will take place on Thursday, 13 May to Saturday, 15 May 2004, as part of the UFS’s centenary celebrations. Through this event, Kovsiesport will focus on the many sports opportunities offered on campus. Fit or unfit, first team or no team, there is an opportunity for every staff member and student to participate.

This exceptional sporting weekend will start on Thursday, 13 May 2004 at 17:15, with a 2,5km fun run (or walk) on the campus. It will start at Pellies Park (the first official rugby field on campus). Men and women will take part separately in five different categories. They are:

 

  • Lecturing staff members
     
  • Administrative staff members
     
  • Support service staff members
     
  • Hostel residents
     
  • Alumni

    After the fun day on Thursday, the serious sports activities will commence. Different league matches are scheduled to take place from Friday, 14 May to Saturday afternoon, 15 May 2004. The Northern Tertiary Tennis League, as well as the Cross Country City League will take place. Hockey, netball, cricket, squash, basket ball, rugby and soccer matches have also been scheduled. The Shimla’s City Cup match will take place on Saturday afternoon on Shimla Park.

    After the sports activities on Saturday evening, we will have another chance to socialize. Medix Residence is organising a special Idols concert at 19:00 in the Callie Human Centre as part of this fun weekend. Idols from 2002 and 2003 will perform. They are Brandon October, Anke Pietrangelli, Poseletso Sejosingoe and Bianca le Grange. Tickets are available at Computicket (Greyhound stall, Tourist Centre in Park Way).

    The festival will be a weekend to relax and enjoy. Please participate in the fun walk, support Kovsiesport and join the Idols in an evening of song.

     

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