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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Breyten Breytenbach shares his words and philosophies
2013-03-05

 

Breyten Breytenbach
Photo: Johan Roux
02 March 2013

The Department of Philosophy at the University of the Free State (UFS) recently hosted Breyten Breytenbach as part of its Colloquium series.

In a packed Odeion theatre, Breytenbach shared his words and views relating to poetry and philosophy. The session was chaired by Prof Pieter Duvenhage from the Department of Philosophy, who noted the symbiotic relationship which exists between the two seemingly distinct disciplines.

Breytenbach is one of South Africa’s best-known literary sons, gaining worldwide recognition for his writings and poetry, as well as his political activism against the erstwhile Apartheid regime. He left the country in 1960 due to Apartheid and settled in Paris where his first collection of poetry was published in 1964. It was the beginning of a prizewinning literary career spanning multiple languages and decades.

He returned illegally in 1975 in order to agitate against the repressive National Party government, but was arrested, spending seven years in prison after being charged with terrorism.

The audience was treated to a reading from an unpublished work from Breytenbach, A letter to my daughter. The lengthy letter outlined Breytenbach's world views, his sense of the creative process, his philosophies and his takes on current and historical events.

A large part of the letter focused on the philosophical and emotional processes involved in writing.“Writing is the travelling of its own landscape; landscapes and rooms that may always have been there,” he said.

He noted that it’s not always an easy process, and that sometimes writers need to explore the abysses, which can be unnerving.

“In this regard it is important to know that emptiness exists,” he said.

He stressed his concern over some of the problems the country currently faces, especially the abuse of state institutions. He was especially worried about the abuse of power. He warned that “power has its own predatory identity,” often abused and misused by those who wield it.

Despite his misgivings, Breytenbach still retains his optimism for the country and its people. He remarked that the country and its many diverse cultures resembles a “fantastic patchwork blanket,” one that should be cherished and protected.

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