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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Goodbye SIFE, hello Enactus
2013-05-01

The Kovsies Enactus team
24 May 2013
Photo: Linda Fekisi

The Students in Free Enterprise, better known as SIFE, has changed its brand name to Enactus. This global rebranding took place late last year. It forms part of an attempt to increase the organisation’s level of reach and impact. It reflects that entrepreneurial action is not something that is relevant to a single culture or nationality.

The organisation is still in essence one which assists university students to create community empowerment projects. The Kovsies Enactus team has 53 active members on the Bloemfontein Campus.

“We encourage student development through Enactus. It is a great platform for students. There is a combination of ideas, expertise and diversity from different faculties,” says the Vice-Chairperson of internal affairs, Mirriam Matsoaboli.

Enactus is currently working on three major projects: Local Economic Development (LED) and Edcon, Shifting Focus, and an environmental project. LED works with 19 established businesses which are struggling to make a profit while Edcon deals with three designers in textile and clothes making. Shifting Focus forms part of the educational division. It focuses on instilling entrepreneurial skills in high school learners. The Enactus team serves as a mentoring structure and advises them. The environmental project is in its infant stage, with. Enactus working on recycling bottles and paper, especially old study guides on campus.

“Having a branch on the QwaQwa campus has also been one of our objectives. We are still in the process of establishing one,” adds Mirriam.

The Enactus team is currently preparing for the national competitions which will take place later in Sandton on 10 and 11 July.

  • Students tell us about your association and we will profile it on our Kovsielife page. Contact Amanda Tongha at tonghaa@ufs.ac.za

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