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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Marikana and its subsequent economic and political consequences
2013-05-30

 

Dawie Roodt and Prof Adam Habib
30 May 2013

The Marikana incident is a bitter moment for South Africa's new political establishment; a tragedy on the same scale as Sharpeville and the Soweto massacre.

This is how Prof Adam Habib, Vice-Chancellor and Principal designate of the University of the Witwatersrand, described the sorrow during the CR Swart Memorial Lecture hosted by the Department of Political Studies and Governance.

Speaking on the topic The Post-Marikana landscape in South Africa, Prof Habib and Dawie Roodt, Chief Economist and Director of the Efficient Group, gave their views on the political and economic challenges confronting the country.

Prof Habib, a well-known political commentator, explained to the fully-packed CR Swart Auditorium how this tragedy provoked a national soul-searching.

Referencing from his highly-anticipated book South Africa's Suspended Revolution, Hopes and Prospects, Prof Habib said the difficulty Marikana poses is the challenge of inequality. According to him, inequality is the single biggest challenge of the South African society. He firmly believes that taking responsibility for poverty is a moral necessity. "Addressing poverty is absolutely crucial if we want to be a humane society."

In his presentation, Roodt informed the audience regarding recent data on population growth, unemployment and dependency ratios. These statistics gave an indication of how the country is doing. The economist said the only way to address unemployment, inequality and poverty is through economic growth.

"If we want to do something about inequality, we have to do something about skills – particularly skills for women. We must make it easier for people to get jobs," Roodt emphasised.

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