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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

SRC and Kovsies stand against abuse
2014-04-16

The SRC took the lead on Monday by orchestrating a campaign to create awareness and instill consciousness on campuses to act against the abuse of women and children.

During a march from the Thakaneng Bridge to the Main Building on the Bloemfontein Campus, the SRC led students in a Pledge Against Women and Children Abuse to ensure that the UFS community become accountable. The message proclaimed, was one of zero tolerance for the abuse of women and children.

The Dean of Student Affairs, Rudi Buys, addressed students, saying: “No more. This cannot be just another march, but something to speak directly to injustice.”

This campaign was aimed at ensuring that relevant information and services are provided to help women and children. Representatives of Health and Wellness, psychologists and social workers, as well as representatives from the Centre of Trauma Forgiveness and Reconciliation, the Centre for Safety and Security and the Institute of Race and Reconciliation were present during this campaign.
The Vice-Rector: External Relations, Dr Choice Makheta, stressed the point of women and children’s wellbeing, by saying: “As a university we must make sure women are treated well… that children are treated very well.”

Violence against women and children in South Africa happens regardless of age, class or colour. Studies shows 50% of women have been reported experiencing violence at the hands of their intimate partners. Local studies also show that 28% of men have admitted to being rapists. Every hour a child is abused in South Africa.

But Kovsies say “No more! No more!”

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