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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

Kovsies in top four in Global Business Challenge
2015-05-06

Photo: Mark Steenbok (Bloemfontein Courant) 

 

Christiaan Paulsen (team leader), Sias Conradie, Jannie de Wet and Frikkie Jacobs.

Four Kovsies in the Department of Mathematical Statistics and Actuarial Sciences are one of the top four teams in the Chartered Institute of Management Accountants’ (CIMA) Global Business Challenge. 178 teams registered to participate in the competition.

 

Team Bernoulli from the UFS will compete against two teams: one from the University of Pretoria and one from the Chartered Accountant Training Institute in Sandton. The winning team will win a trip to Poland, Europe to represent their university and country at the 2015 global final.

 

This international business competition is for undergraduates around the world, designed to bring out the best in the young business leaders of tomorrow.

 

Team leader, Christiaan Paulsen, said: “We are overjoyed to be in the final. However, our true success is in what we learned along the way”.

 

The team has to present a business case study, showcasing their talent in business management. During this competition, the team has

  • learned to analyse and solve a real-life business case study;
  • -obtained first-hand experience of the skills required to be a business leader;
  • enhanced their team building skills; and 
  • developed their presentation skills.  

Students from Australia, Bangladesh, China, Ghana, Hong Kong SAR, India, Indonesia, Ireland, GCC, Malaysia, Myanmar, Nepal, New Zealand, Nigeria, Pakistan, Phillipines, Poland, Russia, Singapore, South Africa, Sri Lanka, Thailand, Ukraine, United Kingdom, Vietnam, and Zambia are taking part in the competition.

 

This competition is organised by CIMA in conjunction with Barclays.

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