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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Alcinda Honwana: Youth Protests Main Mechanism against Regime
2015-05-25

Prof Alcinda Honwana

"Enough is Enough!": Youth Protests and Political Change in Africa (speech) 

The Centre for Africa Studies at the UFS hosted an interdisciplinary project on the Bloemfontein Campus from 20-22 May 2015.

The project, entitled Contemporary Modes of Othering: Its Perpetuation and Resistance, looked at different perspectives, representations, and art forms of otherness, how it is perceived, and how it is resisted.

The annual Africa Day Memorial Lecture was held on Thursday evening 21 May 2015 at the CR Swart Auditorium. Guest speaker Prof Alcinda Honwana addressed the subject of ‘Youth Protests and Political Change in Africa’.

“Youth now seem able to display what they don’t want, rather than what they do want,” Honwana said in her opening remarks. “Thus, we see the young driven to the streets to protest against regimes.”
 
Honwana shed some light on recent examples of youth protests in Africa that have enjoyed global attention. Looking at the protests in Tunisia (2010), Egypt (2011), Senegal (2012), and Burkina Faso (2014), it is clear that these events in northern and western Africa have inspired others globally. Yet, Honwana stated that, despite these protests, no social economic change has been seen, and has left dissatisfaction with new governments as well.

“Once regimes fall… young activists find themselves more divided, it seems…

“Which leaves the question: Will street protests remain young people’s main mechanism to avert those in power?”

Background on Prof Alcinda Honwana:

Alcinda Honwana is currently Visiting Professor of Anthropology and International Development at the Open University (UK). She was chair in International Development at the Open University, and taught Anthropology at the University Eduardo Mondlane in Maputo, the University of Cape Town in South Africa, and the New School for Social Research in New York. She was programme director at the Social Science Research Council in New York, and worked for the United Nations Office for Children and Armed Conflict. Honwana has written extensively on the links between political conflict and culture, and on the impact of violent conflict on children and youth, conducting research in Mozambique, the Democratic Republic of the Congo, Angola, Colombia, and Sri Lanka. Her latest work has been on youth and social change in Africa, focusing on Mozambique, Senegal, South Africa, and Tunisia.

Honwana’s latest books include:

• Youth and Revolution in Tunisia (2013); 
• Time of Youth: Work, Social Change, and Politics in Africa (2012);
• Child Soldiers in Africa (2006);
• Makers and Breakers: Children and Youth in Postcolonial Africa (2005, co-edited).

Honwana was awarded the prestigious Prince Claus Chair for Development and Equity in the Netherlands in 2007.

 

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