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09 June 2022 | Story André Damons | Photo Supplied
Prof Motlalepula Matsabis
Prof Motlalepula Matsabisa is a professor and Director of Pharmacology at the University of the Free State (UFS) and will play host to and lead a World Health Organisation (WHO) Africa Centre for Disease Control and Prevention (Africa CDC), the European and Developing Countries Clinical Trials Partnership (EDCTP) and the African Union Commission (AU) mission to South Africa.

Prof Motlalepula Matsabisa, Director of Pharmacology at the University of the Free State (UFS), and his department will host representatives from the World Health Organisation (WHO) Africa Centre for Disease Control and Prevention (Africa CDC), the European and Developing Countries Clinical Trials Partnership (EDCTP), the African Union Commission (AU) and the World Health Organisation’s (WHO) Regional Expert Advisory Committee on Traditional Medicines for COVID-19 (REACT) experts, during a mission to South Africa.  

According to Prof Matsabisa, who is the chairperson of REACT, the main purpose of the mission is to meet with researchers in preclinical and as well as those conducting clinical trials for herbal medicines for COVID-19, medicines regulators, ethics committee and the local pharmaceutical companies in the herbal medicines production for COVID-19. The expected outcome of this mission is to take stock of best practices or challenges in traditional medicines research, clinical trials, ethics and medicine regulation around traditional medicines as well as capabilities in local traditional medicine products production.  

“The mission will also be looking at technical capabilities for researchers to conduct clinical trials, identify facilities conducting clinical trials, as well as pharmaceutical companies in local production of herbal medicinal products so as to recommend to the AU, countries and member states about these capabilities and how to pool resources together.

“The mission will also be looking for best research traditional medicinal products that have undergone preclinical and clinical research and produced locally so that such products could be recommended for endorsement by the WHO. At the end of the mission a report will be produced and presented to the WHO and the Department of Health and all stakeholders as well as making this report available to WHO HQ in Geneva,” says Prof Matsabisa.

This is an excellent mission given that it has been recognising the research excellence of the UFS Pharmacology IKS to attract international United Nations (UN) bodies and the AU. The Indigenous Knowledge System (IKS) for Health in the Department of Pharmacology, within the UFS Faculty of Health Sciences, has excelled in the research and development of traditional medicines.  

“The Pharmacology IKS is the first in the country and sub-region to have its research product PHELA, a traditional medicine, to receive ethics approval from Pharma Ethics and South African Health Products Regulatory Authority (SAHPRA) to be tested in a Phase II clinical trial on COVID-19 patients. This clinical study is a multicentre study conducted at clinical trial sites in Vereeniging, Kimberley and Port Elizabeth.  

“It is for this reason that Pharmacology IKS is hosting the WHO Africa CDC, EDCTP and the AU Commission Mission to South Africa delegation for coming to note the best research practices on traditional medicines research, clinical trials and manufacturing of the herbal medicinal products. Pharmacology IKS will take this mission around the country to visit key collaborators in the project, to funders of the project, and some industry partners involved in the research and production of PHELA.” 

The delegation will be at the UFS Bloemfontein Campus for the whole day of 17 June 2022, meeting with senior management, meeting chairpersons of ethics committees, visiting different laboratories including Virology, Medical Microbiology, Pharmacology and Farmovs. The other institutions the mission will meet include the National Department of Health, South African Health Products Regulatory Authority (SAHPRA), Pharma Ethics, Technology Innovation Agency (TIA) and the Department of Science and Innovation (DSI) on 13 June 2022. The high-level delegation will visit all three clinical trial sites in Vereeniging, Kimberley and Gqeberha where the Pharmacology PHELA COVID-19 clinical trials are being undertaken. During the visits the mission delegation will be in discussion with participants about best practices that could be taken and expanded throughout the continent and also to hear about challenges so that the WHO could assist.

News Archive

Research into veld fires in grassland can now help with scientifically-grounded evidence
2015-04-10

While cattle and game farmers are rejoicing in the recent rains which large areas of the country received in the past growing season, an expert from the University of the Free State’s Department of Animal, Wildlife, and Grassland Sciences, says that much of the highly inflammable material now available could lead to large-scale veld fires this coming winter.

Prof Hennie Snyman, professor and  researcher in the Department of Animal, Wildlife, and Grassland Sciences, warns that cattle and game farmers should be aware, in good time, of this problem which is about to rear its head. He proposes that farmers must burn firebreaks as a precaution.

At present, Prof Snyman focuses his research on the impact of fire and burning on the functioning of the grassland ecosystem, especially in the drier grassland regions.

He says the impact of fire on the functioning of ecosystems in the ‘sour’ grassland areas of Southern Africa (which includes Kwazulu-Natal, Limpopo, Mpumalanga, the Eastern Cape, and the Harrismith environs) is already well established, but less information  is available for ‘sweet’ semi-arid grassland areas. According to Prof Snyman, there is no reason to burn grassland in this semi-arid area. Grazing by animals can be effectively used because of the high quality material without having to burn it off. In the sourer pasturage, fire may well form part of the functioning of the grassland ecosystem in view of the fact that a quality problem might develop after which the grass must rejuvenate by letting it burn.

Prof Snyman, who has already been busy with the research for ten years, says quantified data on the impact of fire on the soil and plants were not available previously for the semi-arid grassland areas. Fires start frequently because of lightning, carelessness, freak accidents, or damaged power lines, and farmers must be recompensed for this damage.

The shortage of proper research on the impact of fires on soil and plants has led to burnt areas not being withdrawn from grazing for long enough. The lack of information has also led to farmers, who have lost grazing to fires, not being compensated fairly or even being over-compensated.

“When above-and below-ground plant production, together with efficient water usage, is taken into account, burnt grassland requires at least two full growing seasons to recover completely.”       

Prof Snyman says farmers frequently make the mistake of allowing animals to graze on burnt grassland as soon as it begins to sprout, causing considerable damage to the plants.

“Plant roots are more sensitive to fire than the above-ground plant material. This is the reason why seasonal above-ground production losses from fire in the first growing season after the fire can amount to half of the unburnt veld. The ecosystem must first recover completely in order to be productive and sustainable again for the long term. The faster burnt veld is grazed again, the longer the ecosystem takes to recover completely, lengthening the problem with fodder shortages further.  

Prof Snyman feels that fire as a management tool in semi-arid grassland is questionable if there is no specific purpose for it, as it can increase ecological and financial risk management in the short term.

Prof Snyman says more research is needed to quantify the impact of runaway fires on both grassland plant productivity and soil properties in terms of different seasonal climatic variations.

“The current information may already serve as valuable guidelines regarding claims arising from unforeseen fires, which often amount to thousands of rand, and are sometimes based on unscientific evidence.”

Prof Snyman’s research findings have been used successfully as guidelines for compensation aspects in several court cases.

 

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