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27 September 2022 | Story André Damons | Photo Charl Devenish
Prof Martin Nyanga
Prof Martin Nyaga, Associate Professor in the UFS-NGS Unit and Director of the WHO Collaborating Centre (WHO CC), says the UFS researchers – through the Division of Virology/NHLS and the UFS-NGS Unit – were involved in the major publication as part of the NGS-SA consortium from the study design phase, ethics applications, and throughout the study.

Researchers from the University of the Free State (UFS) Next Generation Sequencing (UFS-NGS) Unit and Division of Virology/ National Health Laboratory Service (NHLS) were part of a major publication featuring hundreds of authors from Africa who did research on the evolution of SARS-CoV-2.

The scientific publication in the journal Science (impact factor 47.728) featured more than 300 scientists and public health officials from Africa and abroad, who worked together to look into the evolution of SARS-CoV-2, the viral agent causing COVID-19. It was the first collaborative study of this nature conducted in Africa during the COVID-19 global pandemic. The publication became available online on 15 September this year. 

According to a press release by the Centre for Epidemic Response and Innovation (CERI) at Stellenbosch University and the KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP) at the University of KwaZulu-Natal (UKZN), this was the largest consortium of African scientists and public health institutions working together to support data-driven COVID-19 response in Africa. This collaboration was led by two labs (CERI and KRISP) and the Network for Genomic Surveillance in South Africa (NGS-SA) consortium, of which the UFS-NGS Unit and Division of Virology are founding members, in close coordination with the Africa CDC, WHO/AFRO and 300 other institutions across the continent.

It is an awesome feeling

Prof Martin Nyaga, Associate Professor in the UFS-NGS Unit and Director of the WHO Collaborating Centre (WHO CC), says the UFS researchers – through the Division of Virology/NHLS (coordinated by Prof Dominique Goedhals and Mr Philip Armand Bester) and also the UFS-NGS Unit (Prof Nyaga, Dr Peter Mwangi, Mr Milton Mogotsi, and Mr Emmanuel Ogunbayo) – were involved as part of the NGS-SA consortium from the study design phase, ethics applications, and throughout the study, processing the SARS-CoV-2 positive samples for whole-genome sequencing, thus generating significant sequence data of the SARS-CoV-2 variants circulating in South Africa.

“It is an awesome feeling to be part of the solution in resolving the COVID-19 pandemic by providing data that would track variants in real time and data used to implement prophylactic solutions, such as vaccine development, against a virus that was a global threat,” says Prof Nyaga. 

According to him, the utility of next-generation sequencing technologies in understanding genomics of diseases was clearly demonstrated in this study and will assist in addressing future diseases/pandemics. These genomic studies provide deeper insights regarding diseases, and they will provide timely solutions to solving diseases affecting the Mother Continent.

UFS Free State variants study

Prof Nyaga says their Free State variants study, which was also recently published in the journal Frontiers in Virology, performed analysis of samples from patients who tested positive for SARS-CoV-2 throughout all the COVID-19 waves. “We aimed to determine whether the variants driving the epidemic waves at the national level were also driving the epidemic waves at the local level, in the context of the Free State province. The data further indicates that SARS-CoV-2 variants driving the epidemic waves in the Free State at the local level correlated with the ones driving the epidemic waves at the national level. Findings from this study highlight the importance of continued genomic surveillance and monitoring of the circulating SARS-CoV-2 variants to inform public health efforts and ensure adequate control of the ongoing pandemic. 

“Our data has been incorporated into the analyses of the bigger continent-wide collaboration on genomics surveillance to determine how the majority of COVID-19 variants were introduced into Africa, which has now been published in the journal Science,” says Prof Nyaga.  
The publication highlights that sustained investment in diagnostics and genomic surveillance in Africa was needed to not only help combat SARS-CoV-2 on the continent, but to establish a platform to address the emerging, re-emerging, endemic infectious disease threats, such as Ebola, HIV/Aids, TB, malaria, and enteric disease-causing viruses.

News Archive

Leader of Bafokeng nation delivers a guest lecture at UFS
2011-05-05

 
Kgosi Leruo Molotlegi, leader of the Royal Bafokeng, Proff. Teuns Verschoor, Vice-Rector: Institutional Affairs, Jonathan Jansen, Vice-Chancellor and Rector of our university, and Hendri Kroukamp, Dean of our Faculty Economic and Management Sciences (acting).
Photo: Stephen Collett

Kgosi Leruo Molotlegi, leader of the Royal Bafokeng nation, asked the pertinent questions: Who decides our fate as South Africans? Who owns our future? in the JN Boshoff Memorial Lecture at our university.

He said: “It’s striking that today, with all the additional freedoms and protections available to us, we have lost much of the pioneering spirit of our ancestors. In this era of democracy and capitalist growth (systems based on choice, accountability, and competition), we nevertheless invest government with extraordinary responsibility for our welfare, livelihoods, and even our happiness. We seem to feel that government should not only reconcile and regulate us, but also house us, school us, heal us, employ us, even feed us.

“And what government can’t do, the private sector will. Create more jobs, invest in social development and the environment, bring technical innovations to our society, make us part of the global village. But in forfeiting so much authority over our lives and our society to the public and private sectors, I believe we have given away something essential to our progress as people and a nation: the fundamental responsibility we bear for shaping our future according to aims, objectives, and standards determined by us.”

He shared the turnaround of the education system in the 45 schools in the 23 communities of the Bafokeng nation and the effect of greater community, NGOs, the church and other concerned parties’ engagement in the curricula and activities with the audience. School attendance improved from 80% to 90% in two years and the top learners in the matric maths in Northwest were from the Bafokeng nation. 

Kgosi Leruo Molotlegi stressed the need for people to help to make South Africa a better place: “As a country, we speak often of the need for leadership, the loss of principles, a decline in values. But too few of us are willing to accept the risk, the expense, the liability, and sometimes even the blame, that accompanies attempting to make things better. We are trying to address pressing issues we face as a community, in partnership with government, and with the tools and resources available to us as a traditionally governed community. It goes without saying that we can and should play a role in deciding our fate as members of this great country, and in the Royal Bafokeng Nation, as small as it is, we are determined to own our own future.”

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