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21 April 2023 | Story Andre Damons | Photo Charl Devenish
Dr Emms
Dr Ayodeji Emmanuel Ogunbayo (right), who graduated this week with a Doctor of Philosophy degree with specialisation in Medical Virology, with his proud supervisor Prof Martin Nyaga, Associate Professor in the UFS Next Generation Sequencing (UFS-NGS).

With respiratory diseases contributing to the highest morbidity and mortality rate in children, and the vast majority of disease aetiology remaining undiagnosed in clinical settings, Dr Ayodeji Emmanuel Ogunbayo hopes his research for his PhD in Medical Virology will help to reduce mortality in children with respiratory infection.

Dr Ogunbayo, commonly known as Dr Emms by his peers, graduated on Thursday (20 April 2023) with a Doctor of Philosophy degree with specialisation in Medical Virology at the University of the Free State (UFS) Faculty of Health Sciences graduation ceremony. The title of his thesis was Metagenomics of the respiratory RNA virome of children in the Free State. His supervisor was Prof Martin Nyaga, Associate Professor in the UFS Next Generation Sequencing (UFS-NGS) and Director of the WHO Collaborating Centre (WHO CC).

“While clinical metagenomics next-generation sequencing (mNGS), which is an upcoming method, has the potential to revolutionise infection diagnosis and management in children, there is a dearth of information on its clinical applicability in Africa. This is the knowledge that guided the inception of this research,” says Dr Ogunbayo.

Project came at the right time

He commenced with his PhD in Medical Virology in 2019, which was centred on the applicability of mNGS in severe acute respiratory infection (SARI) in children and deciphering the children’s respiratory virome in health and disease, a project which was the first of its kind in Africa.

According to him, the project was conceived before the COVID-19 pandemic, however, despite the challenges encountered due to lockdown measures, the project came at the right time as it was able to address several profound effects of the pandemic such as COVID-19 on the dynamics of transmission of respiratory viruses and ultimately its effect on children’s health. During his PhD study, he published four manuscripts in highly reputable journals including the most recent one which was accepted in Journal of Medical Virology (JMV)  an impressive impact factor of 20.693.

The findings from this study included a validated and robust workflow to recover respiratory RNA viruses from clinical samples, according to the graduation programme. The established workflow was adapted to decipher children’s respiratory virome composition in health and disease, with a degree of heterogeneity, while simultaneously establishing the clinical diagnostic applicability of mNGS and, more importantly, the increased utility of dual-triple mNGS analysis tools in robust detection of viral pathogens in SARI.

His hope for the research

Dr Ogunbayo says: “This research generated vast pioneering information and data in Africa that could guide and influence policy in the adoption of clinical metagenomics, especially in cases where conventional methods of diagnosis yielded no results. Hopefully, this could lessen mortality due to respiratory infection in children.

Before studying in the field of medical Microbiology and Virology, he wanted to be a psychiatric nurse, but instead chose his current field of study because of his interest in the microbial world and pathology.

“It’s a feeling one cannot really put into words. A part of me feels like it is a ‘dream come true’ and another part of me feels like ‘this is a milestone achieved, but it’s just a stepping stone to further milestones to be achieved’.

“What is next is for me to dive into the world of policy-influencing research, give back to the academic community through student supervision, and work on my journey to becoming an emerging researcher. This is the reason I have taken a postdoctoral position at the UFS-NGS Unit under the mentorship of Prof Martin Nyaga.”

Prof Nyaga says: “Looking back at Emmanuel’s doctoral journey, it brought out the best in him in every aspect of the study. Longitudinal studies are hectic in the sampling phase, and all the ethical clearances that a study must achieve prior to beginning the sampling and the laboratory work can be very frustrating. Soon after his study was approved, the pandemic lockdown level 5 rules were applied, which meant he had to pause on the study. However, his focus, positive mindset and his ability to work in close consultation with his supervisor enabled him to finish this study in the best way possible. I am very proud of him.”

News Archive

Researcher takes home gold at international Famelab competition
2017-06-26

Description: Famelab competition Tags: Famelab competition

UFS researcher nabbed a top international award for
her ground-breaking metallurgical research in the UK.
Photo: Supplied

Recently, University of the Free State (UFS) Centre for Environmental Management master’s student, Tshiamo Legoale, was announced the FameLab International champion at the Cheltenham Science Festival in the United Kingdom. She is probing methods to use wheat as a gold hyper-accumulator – or, as she puts it, “grow gold from wheat”. The young researcher made South Africa proud by winning both the audience’s and the judges’ vote.

Coming back home a hero
“Winning was a surprise to me, because all 31 contestants had wonderful research. They all had really good presentations. I’m very grateful for all the support that I received from home. Social media showed me a lot of love and support. When I felt unconfident, they gave me ‘likes’ and that boosted my confidence a bit,” said Legoale about her win.

As South Africa celebrates Youth Month in June, Tshiamo represents hope for thousands of young South Africans to overcome difficult circumstances and follow careers in science.

The human impact is crucial, because Legoale’s win is not only scientific. It is also social and political. As a young female scientist in South Africa, she represented one of three African countries making it to the finals of FameLab, which has grown to one of the largest science communication competitions internationally.

With this in mind, Legoale says it may, in the end, be necessary to balance the needs of communities with the desire to increase yield. “Are we looking to make a fortune or are we looking to put food on the table?” she asks. “These are all things we consider when we conduct such research.”

World-class research from Africa
In South Africa, an estimated 17.7 million tons of gold is wasted. “All this gold was mined out previously, but tiny amounts remain in the dumps,” Legoale explains.

Her research focuses on the uses of wheat as a gold hyper-accumulator, which essentially means wheat plants are used to harvest gold from mine dumps. Simply put, the wheat is planted in the dumps, where enzymes found in the roots react with the gold and the plant absorbs it. The gold is then absorbed by every part of the plant, except the seeds, which means the next harvest can be used for food if need be.

“South Africa's world-champion young scientist, Tshiamo, represents all that is good about this country – brilliant, bright, and set for a fine future. I'm so proud that British Council SA, together with our partners SAASTA and Jive Media Africa, can help her along the way. Huge congratulations to her from all of us – it is a big win for Africa on the world stage,” said Colm McGivern, British Council South Africa Country Director.

The research represents a win on multiple levels. First, there are the obvious potential socio-economic benefits: food production, job creation, and phytomining is more economical than other contemporary mining methods.

Then there is safety. It is a more environmentally friendly practice than methods like heap leaching, carbon-in-leach or carbon-in-pulp. It is also safer for miners themselves, who will not be exposed to dangerous chemicals like mercury, which has been responsible for a great deal of toxicity in mine dumps. And it is safer for those living in the surrounds.

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