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21 April 2023 | Story Andre Damons | Photo Charl Devenish
Dr Emms
Dr Ayodeji Emmanuel Ogunbayo (right), who graduated this week with a Doctor of Philosophy degree with specialisation in Medical Virology, with his proud supervisor Prof Martin Nyaga, Associate Professor in the UFS Next Generation Sequencing (UFS-NGS).

With respiratory diseases contributing to the highest morbidity and mortality rate in children, and the vast majority of disease aetiology remaining undiagnosed in clinical settings, Dr Ayodeji Emmanuel Ogunbayo hopes his research for his PhD in Medical Virology will help to reduce mortality in children with respiratory infection.

Dr Ogunbayo, commonly known as Dr Emms by his peers, graduated on Thursday (20 April 2023) with a Doctor of Philosophy degree with specialisation in Medical Virology at the University of the Free State (UFS) Faculty of Health Sciences graduation ceremony. The title of his thesis was Metagenomics of the respiratory RNA virome of children in the Free State. His supervisor was Prof Martin Nyaga, Associate Professor in the UFS Next Generation Sequencing (UFS-NGS) and Director of the WHO Collaborating Centre (WHO CC).

“While clinical metagenomics next-generation sequencing (mNGS), which is an upcoming method, has the potential to revolutionise infection diagnosis and management in children, there is a dearth of information on its clinical applicability in Africa. This is the knowledge that guided the inception of this research,” says Dr Ogunbayo.

Project came at the right time

He commenced with his PhD in Medical Virology in 2019, which was centred on the applicability of mNGS in severe acute respiratory infection (SARI) in children and deciphering the children’s respiratory virome in health and disease, a project which was the first of its kind in Africa.

According to him, the project was conceived before the COVID-19 pandemic, however, despite the challenges encountered due to lockdown measures, the project came at the right time as it was able to address several profound effects of the pandemic such as COVID-19 on the dynamics of transmission of respiratory viruses and ultimately its effect on children’s health. During his PhD study, he published four manuscripts in highly reputable journals including the most recent one which was accepted in Journal of Medical Virology (JMV)  an impressive impact factor of 20.693.

The findings from this study included a validated and robust workflow to recover respiratory RNA viruses from clinical samples, according to the graduation programme. The established workflow was adapted to decipher children’s respiratory virome composition in health and disease, with a degree of heterogeneity, while simultaneously establishing the clinical diagnostic applicability of mNGS and, more importantly, the increased utility of dual-triple mNGS analysis tools in robust detection of viral pathogens in SARI.

His hope for the research

Dr Ogunbayo says: “This research generated vast pioneering information and data in Africa that could guide and influence policy in the adoption of clinical metagenomics, especially in cases where conventional methods of diagnosis yielded no results. Hopefully, this could lessen mortality due to respiratory infection in children.

Before studying in the field of medical Microbiology and Virology, he wanted to be a psychiatric nurse, but instead chose his current field of study because of his interest in the microbial world and pathology.

“It’s a feeling one cannot really put into words. A part of me feels like it is a ‘dream come true’ and another part of me feels like ‘this is a milestone achieved, but it’s just a stepping stone to further milestones to be achieved’.

“What is next is for me to dive into the world of policy-influencing research, give back to the academic community through student supervision, and work on my journey to becoming an emerging researcher. This is the reason I have taken a postdoctoral position at the UFS-NGS Unit under the mentorship of Prof Martin Nyaga.”

Prof Nyaga says: “Looking back at Emmanuel’s doctoral journey, it brought out the best in him in every aspect of the study. Longitudinal studies are hectic in the sampling phase, and all the ethical clearances that a study must achieve prior to beginning the sampling and the laboratory work can be very frustrating. Soon after his study was approved, the pandemic lockdown level 5 rules were applied, which meant he had to pause on the study. However, his focus, positive mindset and his ability to work in close consultation with his supervisor enabled him to finish this study in the best way possible. I am very proud of him.”

News Archive

UFS welcomes two new deans in the faculties of Theology and Law
2014-08-04

 

The university council has approved the appointment of two deans: Prof Fanie Snyman, at the Faculty of Theology and Prof Caroline Nicholson, at the Faculty of Law.

Both professors offer the university a wealth of knowledge and experience in research and teaching.

Prof Fanie Snyman

Prof Snyman joined the university in 1984 as a senior lecturer in the Department Old Testament. His career followed a steadfast ascent which led him to attaining the title of professor and head of department the following year. On 1 July 2013, Prof Snyman took on the additional role of acting dean of the faculty.

As dean, he set out a clear vision of academic leadership with four primary focus areas: research, teaching and learning, internationalisation and regional engagement.

He is the author of eight books and contributed to seven internationally- and twelve nationally-published books. He has published nine articles in international journals and about 60 more in accredited journals.

Prof Snyman proposes to bring staff members together to extensively rethink and reposition the faculty in terms of identity, transformation and the way forward. “We live in a complex world, characterised by uncertainty and in constant change. This calls for complex but also innovative solutions,” he says.

Prof Caroline Nicholson

Prof Caroline Nicholson was born in Scotland and came to South Africa as a young child. She obtained her BProc and LLB degrees at the University of the Witwatersrand and completed her articles of clerkship at Chernin’s in Hyde Park Corner, Johannesburg. Prof Nicholson was admitted as both an attorney and notary public of the then Supreme Court of South Africa in 1986.

In 1986 she joined the University of South Africa (UNISA ) as a lecturer and remained there until 1999. During this time she completed an LLM in Banking Law and an LLD in Comparative Conflict of Laws – focusing on international parental child abduction. During the same year she moved to the Faculty of Law at the University of Pretoria where she worked for the last fifteen years. In 2003 she completed a Postgraduate Diploma in Alternative Dispute Resolution (ADR) and has an abiding interest in ADR, especially within the Family Law context.

Prof Nicholson has produced numerous articles and research presentations on a variety of legal subjects. Her primary areas of interest are, however, legal education and child law. She is known both nationally and internationally for her research contributions.

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