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21 April 2023 | Story Andre Damons | Photo Charl Devenish
Dr Emms
Dr Ayodeji Emmanuel Ogunbayo (right), who graduated this week with a Doctor of Philosophy degree with specialisation in Medical Virology, with his proud supervisor Prof Martin Nyaga, Associate Professor in the UFS Next Generation Sequencing (UFS-NGS).

With respiratory diseases contributing to the highest morbidity and mortality rate in children, and the vast majority of disease aetiology remaining undiagnosed in clinical settings, Dr Ayodeji Emmanuel Ogunbayo hopes his research for his PhD in Medical Virology will help to reduce mortality in children with respiratory infection.

Dr Ogunbayo, commonly known as Dr Emms by his peers, graduated on Thursday (20 April 2023) with a Doctor of Philosophy degree with specialisation in Medical Virology at the University of the Free State (UFS) Faculty of Health Sciences graduation ceremony. The title of his thesis was Metagenomics of the respiratory RNA virome of children in the Free State. His supervisor was Prof Martin Nyaga, Associate Professor in the UFS Next Generation Sequencing (UFS-NGS) and Director of the WHO Collaborating Centre (WHO CC).

“While clinical metagenomics next-generation sequencing (mNGS), which is an upcoming method, has the potential to revolutionise infection diagnosis and management in children, there is a dearth of information on its clinical applicability in Africa. This is the knowledge that guided the inception of this research,” says Dr Ogunbayo.

Project came at the right time

He commenced with his PhD in Medical Virology in 2019, which was centred on the applicability of mNGS in severe acute respiratory infection (SARI) in children and deciphering the children’s respiratory virome in health and disease, a project which was the first of its kind in Africa.

According to him, the project was conceived before the COVID-19 pandemic, however, despite the challenges encountered due to lockdown measures, the project came at the right time as it was able to address several profound effects of the pandemic such as COVID-19 on the dynamics of transmission of respiratory viruses and ultimately its effect on children’s health. During his PhD study, he published four manuscripts in highly reputable journals including the most recent one which was accepted in Journal of Medical Virology (JMV)  an impressive impact factor of 20.693.

The findings from this study included a validated and robust workflow to recover respiratory RNA viruses from clinical samples, according to the graduation programme. The established workflow was adapted to decipher children’s respiratory virome composition in health and disease, with a degree of heterogeneity, while simultaneously establishing the clinical diagnostic applicability of mNGS and, more importantly, the increased utility of dual-triple mNGS analysis tools in robust detection of viral pathogens in SARI.

His hope for the research

Dr Ogunbayo says: “This research generated vast pioneering information and data in Africa that could guide and influence policy in the adoption of clinical metagenomics, especially in cases where conventional methods of diagnosis yielded no results. Hopefully, this could lessen mortality due to respiratory infection in children.

Before studying in the field of medical Microbiology and Virology, he wanted to be a psychiatric nurse, but instead chose his current field of study because of his interest in the microbial world and pathology.

“It’s a feeling one cannot really put into words. A part of me feels like it is a ‘dream come true’ and another part of me feels like ‘this is a milestone achieved, but it’s just a stepping stone to further milestones to be achieved’.

“What is next is for me to dive into the world of policy-influencing research, give back to the academic community through student supervision, and work on my journey to becoming an emerging researcher. This is the reason I have taken a postdoctoral position at the UFS-NGS Unit under the mentorship of Prof Martin Nyaga.”

Prof Nyaga says: “Looking back at Emmanuel’s doctoral journey, it brought out the best in him in every aspect of the study. Longitudinal studies are hectic in the sampling phase, and all the ethical clearances that a study must achieve prior to beginning the sampling and the laboratory work can be very frustrating. Soon after his study was approved, the pandemic lockdown level 5 rules were applied, which meant he had to pause on the study. However, his focus, positive mindset and his ability to work in close consultation with his supervisor enabled him to finish this study in the best way possible. I am very proud of him.”

News Archive

School of Medicine expands to provide quality tuition
2015-04-20

 

The School of Medicine at the University of the Free State (UFS) has recently extended various training platforms to provide continuous quality tuition to students.

Not only does the school boast a world-class dissection hall but now has plans for additional training facilities at two more hospitals.

The new dissection hall was completed in January 2015 with some final finishing touches that will be done shortly. The hall is newly built as the previous dissection hall has been used for undergraduate anatomy training since 1972.

Dr Sanet van Zyl, Senior Lecturer in the Department of Basic Medical Science, says owing to a prospective growth in the number of medical students as well as changing methods in teaching and learning, the need for a new dissection hall became evident to ensure that students get an optimal learning experience during dissection tuition.

“The new spacious dissection hall is equipped with special lighting and modern equipment for the training programme for second-year medical students. The hall is further equipped with modern sound and computer equipment. A unique camera system will allow students to follow dissection demonstrations on ten screens in the hall. Dissection demonstrations can also be recorded, enabling lecturers to put together new materials for teaching and learning.”

In addition to anatomy teaching for under- and postgraduate medical students, the Department of Basic Medical Science also offers anatomy teaching to under-graduate students from the School of Nursing, the School of Allied Health Professions as well as students from the Natural and Agricultural Sciences (such as students studying Forensic Science). The old dissection hall will still be used for the anatomy training of these students.

“The dissection programme for medical students is of critical importance, not only to acquire anatomical knowledge, but also for the development of critical skills and professionalism of our students. As already mentioned, these modern facilities will enable us to be at the forefront of current development in this field. This will benefit both present and future generations of medical students.”

At the same time, Prof Alan St. Clair Gibson, Head of the School of Medicine, announced that lecturing facilities are being developed at the Kimberley Hospital Complex. There are also plans for study facilities at the UFS’s Qwaqwa Campus and Bongani Hospital in Welkom. The UFS’s planning is also well underway for lecturing and residential facilities for students in Trompsburg, where students will receive training at the Trompsburg Hospital.

“We are very privileged to have these facilities and they will help us to provide world class training for students in the School of Medicine,” Prof St. Clair Gibson says.

 

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