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21 April 2023 | Story Andre Damons | Photo Charl Devenish
Dr Emms
Dr Ayodeji Emmanuel Ogunbayo (right), who graduated this week with a Doctor of Philosophy degree with specialisation in Medical Virology, with his proud supervisor Prof Martin Nyaga, Associate Professor in the UFS Next Generation Sequencing (UFS-NGS).

With respiratory diseases contributing to the highest morbidity and mortality rate in children, and the vast majority of disease aetiology remaining undiagnosed in clinical settings, Dr Ayodeji Emmanuel Ogunbayo hopes his research for his PhD in Medical Virology will help to reduce mortality in children with respiratory infection.

Dr Ogunbayo, commonly known as Dr Emms by his peers, graduated on Thursday (20 April 2023) with a Doctor of Philosophy degree with specialisation in Medical Virology at the University of the Free State (UFS) Faculty of Health Sciences graduation ceremony. The title of his thesis was Metagenomics of the respiratory RNA virome of children in the Free State. His supervisor was Prof Martin Nyaga, Associate Professor in the UFS Next Generation Sequencing (UFS-NGS) and Director of the WHO Collaborating Centre (WHO CC).

“While clinical metagenomics next-generation sequencing (mNGS), which is an upcoming method, has the potential to revolutionise infection diagnosis and management in children, there is a dearth of information on its clinical applicability in Africa. This is the knowledge that guided the inception of this research,” says Dr Ogunbayo.

Project came at the right time

He commenced with his PhD in Medical Virology in 2019, which was centred on the applicability of mNGS in severe acute respiratory infection (SARI) in children and deciphering the children’s respiratory virome in health and disease, a project which was the first of its kind in Africa.

According to him, the project was conceived before the COVID-19 pandemic, however, despite the challenges encountered due to lockdown measures, the project came at the right time as it was able to address several profound effects of the pandemic such as COVID-19 on the dynamics of transmission of respiratory viruses and ultimately its effect on children’s health. During his PhD study, he published four manuscripts in highly reputable journals including the most recent one which was accepted in Journal of Medical Virology (JMV)  an impressive impact factor of 20.693.

The findings from this study included a validated and robust workflow to recover respiratory RNA viruses from clinical samples, according to the graduation programme. The established workflow was adapted to decipher children’s respiratory virome composition in health and disease, with a degree of heterogeneity, while simultaneously establishing the clinical diagnostic applicability of mNGS and, more importantly, the increased utility of dual-triple mNGS analysis tools in robust detection of viral pathogens in SARI.

His hope for the research

Dr Ogunbayo says: “This research generated vast pioneering information and data in Africa that could guide and influence policy in the adoption of clinical metagenomics, especially in cases where conventional methods of diagnosis yielded no results. Hopefully, this could lessen mortality due to respiratory infection in children.

Before studying in the field of medical Microbiology and Virology, he wanted to be a psychiatric nurse, but instead chose his current field of study because of his interest in the microbial world and pathology.

“It’s a feeling one cannot really put into words. A part of me feels like it is a ‘dream come true’ and another part of me feels like ‘this is a milestone achieved, but it’s just a stepping stone to further milestones to be achieved’.

“What is next is for me to dive into the world of policy-influencing research, give back to the academic community through student supervision, and work on my journey to becoming an emerging researcher. This is the reason I have taken a postdoctoral position at the UFS-NGS Unit under the mentorship of Prof Martin Nyaga.”

Prof Nyaga says: “Looking back at Emmanuel’s doctoral journey, it brought out the best in him in every aspect of the study. Longitudinal studies are hectic in the sampling phase, and all the ethical clearances that a study must achieve prior to beginning the sampling and the laboratory work can be very frustrating. Soon after his study was approved, the pandemic lockdown level 5 rules were applied, which meant he had to pause on the study. However, his focus, positive mindset and his ability to work in close consultation with his supervisor enabled him to finish this study in the best way possible. I am very proud of him.”

News Archive

From a dream to a reality: Free State Mother and Child Academic Hospital
2016-08-31

Description: Free State Mother and Child Academic Hospital Tags: Free State Mother and Child Academic Hospital

The message, From a dream to a reality, echoed
throughout the launch of the Mother and
Child Academic Hospital. From left to right:
Dr Khotso Mokhele, Chancellor of the UFS,
Rolene Strauss, Miss World 2014 and
Patron of the Mother and Child Academic Hospital,
Prof André Venter, Head of the Department of
Paediatrics and Child Health, and Dr Riaan Els,
CEO of the Fuchs Foundation South Africa.
Photo: Charl Devenish

“Sometimes dreams do come true, and finally, this institution is starting to dream big dreams.” These were the words of Dr Khotso Mokhele, Chancellor of the University of the Free State (UFS) at the launch of the Free State Mother and Child Academic Hospital collaborative initiative. The launch was an official declaration of intentions regarding the establishing of the hospital, a specialist unit which will focus on paediatric and maternal healthcare, fully supported by the Department of Health in the Free State. As the first Mother and Child Hospital in South Africa, it will be unique.

Under the leadership of Prof André Venter, the UFS Department of Paediatrics and Child Health serves over 250 000 children of the southern regions of the Free State at secondary care level, and is responsible for the tertiary care of nearly one million children from the whole of the Free State and Northern Cape Provinces, as well as some children from Northwest and Eastern Cape Provinces and Lesotho.

As part of a multi-faceted initiative, the 350-bed mother and child hospital will benefit the community of the Free State greatly, and will support the objectives of the Strategic Development Goals. It will further Free State Strategic Transformation Plan (STP) by improving access to healthcare for the most vulnerable members of the population, thus reducing paediatric mortality and improving maternal health. An additional objective of the project is to develop academic excellence, and improve the environment in which medical specialists and subspecialists develop their skills according to international standards.

Prof Jonathan Jansen, Vice-chancellor and Rector of the UFS, described the project as one which captures the head and the heart, as it caters most for little lives, a hub wherein great talent and potential waits to be unleashed. In support of the project, the university has offered a piece of land on the campus where the hospital will be built, thus strengthening the quality of tertiary education.

Former Miss World, Mrs Rolene Strauss, also pledged her support. She said she is honoured to be the patron of the project, one she believes will lead to healthier women, healthier children, and a healthier nation.

In celebration of the 50th anniversary of the Fuchs Foundation, CEO Dr Riaan Els, awarded a donation of R2250000 towards the building of the hospital, a contribution which will bring the project a step closer to its realisation.

Prof André Venter, leader of the project, hopes that it will serve as a blueprint for other academic hospitals in the country, and mark the beginning of an era of highly specialised medical care for humanity’s most precious people.

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