Prof Walter Janse van Rensburg
Position
Professor
Department
School of Biomedical Sciences
Address
30B 413B
Haematology and Cell Biology
G 2
UFS
Telephone
0514053035
Office
Francois Retief Building: Block B 413B
Information

Short CV

Prof Wattie Janse van Rensburg is a full professor in the Human Molecular Biology Unit of the School of Biomedical Sciences within the Faculty of Health Sciences, University of the Free State. He started his formal academic career in 2008 at the University of the Free State. He is an HPCSA-registered biomedical scientist with specialization in haematology, and has a C-2 NRF-rating in molecular haematology. He is a member of the International Society on Thrombosis and Haemostasis (ISTH), the Medical and Scientific Advisory Council (MASAC) of the South African Haemophilia Foundation, and the World Federation of Hemophilia (WFH). He graduated with the degrees Bachelors in Medical Science (Human Biology) and Bachelors in Medical Science Honours (Haematology), both cum laude from the University of the Free State. He completed an MMedSc (Haematology) in 2009, and obtained his PhD in haematology in 2015 from the University of the Free State. In 2022/2023 he completed an ISTH Reach-the-World Fellowship at the Laboratory for Thrombosis Research at KU Leuven`s Kortrijk Campus in Belgium. His research focus is on the molecular basis of common diseases and disorders, with a special focus on the Central South African population. He has published 29 papers in peer-reviewed journals (22 in international journals). He acts as a reviewer for eleven international journals. He has also served as a national evaluator, assessor and moderator for the Committee of Medical Science at the HPCSA. He has a special interest in research ethics, and has served on various research ethics committees at the University of the Free State.

Publications (Short List)

International Publications (N=22)

  1. Janse van Rensburg WJ, Van Marle AC, Geertsema L. Co-Occurrence of HIV-Susceptibility and -Protective HLA Alleles Is a Possible Contributor to the Development of Primary HIV-Associated Thrombocytopenia (PHAT): A Cross-Sectional Study. International Journal of Immunogenetics 2025; 52:249-255. DOI: 10.1111/iji.70003. (Q2: Medicine (Miscellaneous); Impact Factor: 1.1)
  2. Bester C, Kloppers JF, Janse van Rensburg WJ. Genetic variant detection in a South African haemophilia B population. Haemophilia 2024; 30:765-773. DOI: 10.1111/hae.14978. (Q1: Haematology; Impact Factor: 3)
  3. Joubert J, Meiring SM, Janse van Rensburg WJ. The thrombin generation capability of the Chacma baboon (Papio ursinus): implications for haemostatic disease models. Scientific Reports 2023; 13:22968. DOI: 10.1038/s41598-023-50341-8. (Q1: Multidisciplinary; Impact Factor: 3.8)
  4. Janse van Rensburg WJ and Haupt L. Forensic autopsy-confirmed thrombosis-related deaths: the danger in the bones. Journal of Thrombosis and Thrombolysis 2022; 54(3):535-541. DOI: 10.1007/s11239-022-02691-9. (Q2: Haematology; Impact Factor: 2.3)
  5. Janse van Rensburg WJ. Post-mortem evidence of a diverse distribution pattern of atherosclerosis in the South African population. Scientific Reports 2022; 12:11366-11372. DOI: 10.1038/s41598-022-15671-z. (Q1: Multidisciplinary; Impact Factor: 3.8)
  6. Kloppers JF, Du Plessis J, Janse van Rensburg WJ. De Novo intron 22 inversion carrier detection – the emerging value of genetic analysis in a developing country. Plasmatology 2021; 15:1-4. DOI: 10.1177/26348535211038359. (Q4: Haematology; Impact Factor: 0.5)
  7. Janse van Rensburg WJ, De Kock A, Bester C, Kloppers JF. HLA major allele group frequencies in a diverse population of the Free State Province, South Africa. Heliyon 2021; 7(4):e06850. DOI: 10.1016/j.heliyon.2021.e06850. (Q1: Multidisciplinary; Impact Factor: 3.4)
  8. Joubert J, Meiring SM, Conradie C, Lamprecht S, Janse van Rensburg WJ. The effects of streptokinase in a Chacma baboon (Papio ursinus) model of acquired thrombotic thrombocytopenic purpura. Clinical and Experimental Medicine 2021; DOI: 10.1007/s10238-021-00711-1. (Q1: Medicine (miscellaneous); Impact Factor: 3.2)
  9. Janse van Rensburg WJ. Molecular suitability of the Chacma baboon in human targeted von Willebrand factor directed studies. Journal of Medical Primatology 2019; 48(3):171-175. DOI: 10.1111/jmp.12407. (Q2: Veterinary (miscellaneous); Impact Factor: 0.8)
  10. Silasi R, Keshari RS, Lupu C, Janse van Rensburg WJ, Chaaban H, Regmi G, Shamanaev A, Shatzel JJ, Puy C, Lorentz C, Tucker EI, Gailani D, Gruber A, McCarty OJT and Lupu F. Inhibition of contact-mediated activation of Factor XI protects baboons against S aureus-induced organ damage and death. Blood Advances 2019; 3(4):658-669. DOI: 10.1182/bloodadvances.2018029983. (Q1: Haematology; Impact Factor: 7.6)
  11. Janse van Rensburg WJ. Lifestyle change alone sufficient to lower cholesterol in male patient with moderately elevated cholesterol: A case report. American Journal of Lifestyle Medicine 2019; 13(2):148-155. DOI: 10.1177/1559827618806841. (Q2: Medicine (miscellaneous); Impact Factor: 1.5)
  12. Janse van Rensburg WJ and Van der Merwe P. Comparison of commercially available sodium citrate and hirudin containing blood collection tubes in platelet aggregation testing. Medical Science Monitor Basic Science 2017; 23:264-269. DOI: 10.12659/MSMBR.905246. (Q3: Medicine (miscellaneous); Impact Factor: 0.495)
  13. Tersteeg C, Roodt J, J. Van Rensburg W, Dekimpe C, Vandeputte N, Pareyn I, Vandenbulcke A, Plaimauer B, Lamprecht S, Deckmyn H, Lopez JA, De Meyer SF and Vanhoorelbeke K. N-acetylcysteine in preclinical mouse and baboon models of thrombotic thrombocytopenic purpura. Blood 2017; 129(8):1030-1038. DOI: 10.1182/blood-2016-09-738856. (Q1: Haematology; Impact Factor 21.0)
  14. Kloppers JF and Janse van Rensburg WJ. Rapid identification of the intron inversion 22 in haemophilia A. Haemophilia 2017; 23(1):e55-e57. DOI: 10.1111/hae.13142. (Q1: Haematology; Impact Factor: 3)
  15. Janse van Rensburg WJ. Comparison of common platelet receptors between the chacma baboon (Papio ursinus) and human for use in pre-clinical human-targeted anti-platelet studies. Platelets 2016; 27(4):322-32. DOI: 10.3109/09537104.2015.1095878. (Q2: Haematology; Impact Factor: 2.5)
  16. Janse van Rensburg WJ, Badenhorst PN and Roodt JP. The Cape Chacma baboon is not suitable for evaluating human targeted anti-GPVI agents. Platelets 2015; 26(6):552-557. DOI: 10.3109/09537104.2014.952224. (Q2: Haematology; Impact Factor: 2.5)
  17. Pretorius L, Janse van Rensburg WJ, Conradie C, Coetzee MJ. Minimum citrate tube fill volume for routine coagulation testing. The International Journal of Laboratory Hematology 2014; 36(4):493-495. DOI: 10.1111/ijlh.12155. (Q2: Haematology; Impact Factor: 2.2)
  18. Callewaert F, Roodt JP, Ulrichts H, Stohr T, Janse van Rensburg W, Lamprecht S, Rossenu S, Priem S, Willems W, and Holz JB. Evaluation of efficacy and safety of the anti-vWF Nanobody ALX-0681 in a preclinical baboon model of acquired thrombotic thrombocytopenic purpura. Blood 2012; 120(17):3603-3610. DOI: 10.1182/blood-2012-04-420943. (Q1: Haematology; Impact Factor 21.0)
  19. Feys H, Roodt J, Vandeputte N, Pareyn I, Mottl H, Hou S, Lamprecht S, J Van Rensburg W, Deckmyn H, and Vanhoorelbeke K. Inhibition of von Willebrand factor-platelet glycoprotein Ib interaction prevents and reverses symptoms of acute acquired thrombotic thrombocytopenic purpura in baboons. Blood 2012; 120(17):3611-3614. DOI: 10.1182/blood-2012-04-421248. (Q1: Haematology; Impact Factor 21.0)
  20. Thibane VS, Ells R, Hugo A, Albertyn J, Janse van Rensburg WJ, Van Wyk PWJ, Kock JLF, Pohl CH. Polyunsaturated fatty acids cause apoptosis in C. albicans and C. dubliniensis biofilms. Biochimica et Biophysica Acta – General Subjects 2012; 1463-1468. DOI: 10.1016/j.bbagen.2012.05.004. (Q1: Biophysics; Impact Factor: 2.8)
  21. Janse van Rensburg WJ, Roodt JP, Lamprecht S, Meiring SM, Badenhorst PN. Tirofiban versus abciximab: tirofiban is administered at suboptimal dosages when evaluated in an arterial thrombosis model in non-human primates. Clinical and Experimental Medicine 2012; 12(4):257-263. DOI: 10.1007/s10238-011-0171-4. (Q1: Medicine (miscellaneous); Impact Factor: 3.2)
  22. Feys HB, Roodt J, Vandeputte N, Pareyn I, Lamprecht S, J. van Rensburg W, Anderson PJ, Budde U, Louw VJ, Badenhorst PN, Deckmyn H, and Vanhoorelbeke K. Thrombotic thrombocytopenic purpura directly linked with ADAMTS13 inhibition in the baboon (Papio ursinus). Blood 2010; 116(12):2005-2010. DOI: 10.1182/blood-2010-04-280479. (Q1: Haematology; Impact Factor 21.0)

National Publications (N=7)

  1. Lange K, Bisiwe BF, Kloppers JF, Janse van Rensburg WJ. Prevalence of lupus nephritis and the use of serology in a central South African chronic kidney disease patient cohort. South African Medical Journal 2023; 113(4):1132-1133. DOI: 10.7196/SAMJ.2023.v113i4.198. (Q3: Medicine (miscellaneous); Impact Factor: 1.5)
  2. Geertsema L, Van Marle AC, Janse van Rensburg WJ. Prevalence of primary HIV-associated thrombocytopenia in a central South African population. South African Medical Journal 2022; 112(9):738-739. DOI: 10.7196/SAMJ.2022.v112i9.16724. (Q3: Medicine (miscellaneous); Impact Factor: 1.5)
  3. Janse van Rensburg WJ, De Kock A, Bester C, Kloppers JF. HLA and disease: Missing clinical data on laboratory request forms – a missed opportunity. South African Medical Journal 2021; 111(1):4. DOI: 10.7196/SAMJ.2021.v111i1.15390. (Q3: Medicine (miscellaneous); Impact Factor: 1.5)
  4. Kloppers JF, Marx GM, Janse van Rensburg WJ. Intron 22 inversion real-time polymerase-chain reaction detection in haemophilia A families from central South Africa. South African Medical Journal 2019; 109(11):876-879. DOI: 10.7196/SAMJ.2019.v109i11.13979. (Q3: Medicine (miscellaneous); Impact Factor: 1.5)
  5. Kloppers JF and Janse van Rensburg WJ. Evaluation of a chromogenic factor VIII assay on the Sysmex CS 2100I instrument. Medical Technology South Africa 2015; 29(2):27-30.
  6. Botma J, Mogongoa LF, Jafta AD, Janse van Rensburg WJ. Reference ranges for platelet indices using Sysmex XE-2100 blood analyser. Medical Technology South Africa 2012; 26(2):17-21. DOI: 10.10520/EJC129528.
  7. Janse van Rensburg WJ and Badenhorst PN. Evaluation and Implementation of a semi-automated Two-stage Factor VIII Assay. Medical Technology South Africa 2008; 22(2):15-17.

Courses Presented

  • MBChB: MHAE2724, MCLI2720.
  • B. Optom: GENS2611
  • B.Med.Sc (Hons): MBGI6814 (Introductory Immunology), MBGH6814 (Introductory Haematology), MBGP6816 (Research Protocol), MBGR6818 (Research Project), MBGT6804 (Research Techniques).
  • BSc: HMBG3744 (Human Molecular Biology in Immunology and Haemostasis).

 

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