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UFS celebrates excellence through its research hubs
The university considers its research chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership.

The University of the Free State (UFS) is proud of its research leaders. As of 2018 the UFS has 156 NRF-rated researchers and five Sarchi Research Chairs. These chairs are designed to attract and retain excellence in research and innovation at South African public universities.

Getting the better of vector borne and zoonotic viruses

Prof Felicity Burt leads the Vector Borne and Zoonotic Virus Research Group in the Department of Medical Microbiology and Virology at the UFS. She was awarded a Research Chair to, among others, investigate medically significant vector-borne and zoonotic viruses currently circulating - mainly viruses transmitted by mosquitos and ticks, and viruses transmitted from animals to humans. 

“Years ago, no one knew what Ebola was. One outbreak later, backed by many media reports, and it is almost a household name. The same goes for the recent Zika virus outbreak in South America,” she explains the public’s interest and fears. To prevent the spread of vector-borne viruses to new areas, surveillance and awareness is important. Here in Bloemfontein, Prof Burt and her team are establishing surveillance programmes.

Why research on fungal infections?

“Many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections,” says Prof Carlien Pohl-Albertyn, who is heading the Research Chair for Pathogenic Yeasts in the Department of Microbial, Biochemical and Food Biotechnology. And the rise in resistance to antifungal treatments requires research into pathobiology, including new drug and treatment options. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

Understanding higher education for more equality and justice

Prof Melanie Walker, from the Centre for Research on Higher Education and Development (CRHED) does research on higher education, inequalities and social justice, and how, or if, universities foster the human capabilities and aspirations of students. Does higher education make a difference to the lives of students, their families and communities? 

Prof Walker says the Research Chair on Higher Education and Human Development looks at issues of access, participation and transitions into work, as well as gender, race and social class. They use both quantitative and qualitative methods and includes a strand of participatory research projects with students. Ultimately, the research must contribute to debates, policy and practices in higher education, and a scholarly knowledge base.

Reduced emissions make for a better world

Prof Hendrik Swart chairs the research project that looks into low-energy lighting, using phosphor materials for light emitting diodes (LEDs). The Research Chair on Solid State Luminescent and Advanced Materials is situated at the Department of Physics

The research mainly focuses on better light emission of phosphor powers in LEDs.  According to Prof Swart, the long-term benefit of the research will result in more environmentally friendly devices which use less energy, are brighter and give a wider viewing field. Over the next five years they will develop and produce devices that emit better light using the substances already developed. “We need to make small devices to see if they are better than those we already have,” he says. 

Solutions to food insecurity
 

The Department of Plant Sciences’s research project dives into disease resistance and quality in field crops. Heading this Research Chair is Prof Maryke Labuschagne who focuses on crop quality breeding and disease resistance in field crops. 

Her, and her students’ research focuses on the genetic improvement of food security crops in Africa, including such staples as maize and cassava. “These crops are genetically improved for yield, drought tolerance, disease, and insect resistance, as well nutritional value,” she says. Her disease resistance research will focus on crop protein quantity and quality as well as iron, zinc, and beta-carotene biofortification of staple crops such as wheat, maize and cassava. The disease resistance-breeding project will be a continuation of the internationally acclaimed wheat rust research. 

The university considers the research chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. 

Microbiology from University of the Free State on Vimeo.

News Archive

Link between champagne bubbles and the UFS?
2012-11-16

Prof. Lodewyk Kock with an example of a front page of the publication FEMS Yeast Research, as adapted by F. Belliard, FEMS Central Office.
Photo: Leatitia Pienaar
15 November 2012

What is the link between the bubbles in champagne and breakthrough research being done at the Mayo Clinic in America? Nano research being done at our university.

Prof. Lodewyk Kock of Biotechnology says a human being consists of millions of minute cells that are invisible to the eye. The nano technology team at the UFS have developed a technique that allows researchers to look into such a cell, as well as other microorganisms. In this way, they can get an idea of what the cell’s “insides” look like.

The UFS team – consisting of Profs. Kock, Hendrik Swart (Physics), Pieter van Wyk (Centre for Microscopy), as well as Dr Chantel Swart (Biotechnology), Dr Carlien Pohl (Biotechnology) and Liza Coetsee (Physics) – were amazed to see that the inside of cells consist of a maze of small tunnels or blisters. Each tunnel is about 100 and more nanometres in diameter – about one ten thousandth of a millimetre – that weaves through the cells in a maze.

It was also found that these tunnels are the “lungs” of the cells. Academics doing research on yeast have had to sit up and take notice of the research being done at the UFS – to the extent that these “lungs” will appear on the front page of the highly acclaimed FEMS Yeast Research for all of 2013.

The Mayo Clinic, in particular, now wants to work with the UFS to study cancer cells in more detail in order to fight this disease, says Prof. Kock. The National Cancer Institute of America has also shown interest. This new nano technology for biology can assist in the study and development of nano medicine that can be used in the treatment of cancer and other life threatening diseases. Nano medicine uses nano metal participles that are up to one billionth of a metre in size.

Prof. Kock says laboratory tests indicate that nano medicine can improve the efficacy of anti-cancer medicine, which makes the treatment less toxic. “According to the Mayo Clinic team, nano particles are considered as a gold cartridge which is being fired directly at a cancer tumour. This is compared to fine shot that spreads through the body and also attacks healthy cells.”

“This accuracy implies that the chemotherapy dose can be lowered with fewer side effects. The Mayo Clinic found that one-tenth of the normal dosage is more effective against pancreas cancer in this way than the full dosage with a linkage to nano particles. According to the clinic, this nano medicine could also delay the spread of cancer,” says Prof. Kock.

The nano particles are used as messengers that convey anti-cancer treatment to cancer cells, where it then selectively kills the cancer cells. The transport and transfer of these medicines with regard to gold nano particles can be traced with the UFS’s nano technology to collect more information, especially where it works on the cell.

“With the new nano technology of the UFS, it is possible to do nano surgery on the cells by slicing the cells in nanometre thin slices while the working of the nano medicine is studied. In this way, it can be established if the nano medicine penetrates the cells or if it is only associated with the tiny tunnels,” says Prof. Kock.

And in champagne the small “lungs” are responsible for the bubbles. The same applies to beer and with this discovery a whole new reach field opens for scientists.

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