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UFS celebrates excellence through its research hubs
The university considers its research chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership.

The University of the Free State (UFS) is proud of its research leaders. As of 2018 the UFS has 156 NRF-rated researchers and five Sarchi Research Chairs. These chairs are designed to attract and retain excellence in research and innovation at South African public universities.

Getting the better of vector borne and zoonotic viruses

Prof Felicity Burt leads the Vector Borne and Zoonotic Virus Research Group in the Department of Medical Microbiology and Virology at the UFS. She was awarded a Research Chair to, among others, investigate medically significant vector-borne and zoonotic viruses currently circulating - mainly viruses transmitted by mosquitos and ticks, and viruses transmitted from animals to humans. 

“Years ago, no one knew what Ebola was. One outbreak later, backed by many media reports, and it is almost a household name. The same goes for the recent Zika virus outbreak in South America,” she explains the public’s interest and fears. To prevent the spread of vector-borne viruses to new areas, surveillance and awareness is important. Here in Bloemfontein, Prof Burt and her team are establishing surveillance programmes.

Why research on fungal infections?

“Many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections,” says Prof Carlien Pohl-Albertyn, who is heading the Research Chair for Pathogenic Yeasts in the Department of Microbial, Biochemical and Food Biotechnology. And the rise in resistance to antifungal treatments requires research into pathobiology, including new drug and treatment options. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

Understanding higher education for more equality and justice

Prof Melanie Walker, from the Centre for Research on Higher Education and Development (CRHED) does research on higher education, inequalities and social justice, and how, or if, universities foster the human capabilities and aspirations of students. Does higher education make a difference to the lives of students, their families and communities? 

Prof Walker says the Research Chair on Higher Education and Human Development looks at issues of access, participation and transitions into work, as well as gender, race and social class. They use both quantitative and qualitative methods and includes a strand of participatory research projects with students. Ultimately, the research must contribute to debates, policy and practices in higher education, and a scholarly knowledge base.

Reduced emissions make for a better world

Prof Hendrik Swart chairs the research project that looks into low-energy lighting, using phosphor materials for light emitting diodes (LEDs). The Research Chair on Solid State Luminescent and Advanced Materials is situated at the Department of Physics

The research mainly focuses on better light emission of phosphor powers in LEDs.  According to Prof Swart, the long-term benefit of the research will result in more environmentally friendly devices which use less energy, are brighter and give a wider viewing field. Over the next five years they will develop and produce devices that emit better light using the substances already developed. “We need to make small devices to see if they are better than those we already have,” he says. 

Solutions to food insecurity
 

The Department of Plant Sciences’s research project dives into disease resistance and quality in field crops. Heading this Research Chair is Prof Maryke Labuschagne who focuses on crop quality breeding and disease resistance in field crops. 

Her, and her students’ research focuses on the genetic improvement of food security crops in Africa, including such staples as maize and cassava. “These crops are genetically improved for yield, drought tolerance, disease, and insect resistance, as well nutritional value,” she says. Her disease resistance research will focus on crop protein quantity and quality as well as iron, zinc, and beta-carotene biofortification of staple crops such as wheat, maize and cassava. The disease resistance-breeding project will be a continuation of the internationally acclaimed wheat rust research. 

The university considers the research chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. 

Microbiology from University of the Free State on Vimeo.

News Archive

Collaboration between UFS and Mayo Clinic to revolutionise cancer treatment
2014-06-27



Attending the lecture were, from the left: Dr Chantel Swart, Prof Lodewyk Kock, Prof Debabrata Mukhopadhyay, Prof James du Preez; back: Prof Pieter van Wyk.
Dr Swart, Profs Kock and Du Preez are from the Department of Microbial, Biochemical and Food Biotechnology. Prof Mukhopadhyay is from the Mayo Clinic (US) and Prof Van Wyk is from the Centre for Microscopy at the UFS.
Photo: Supplied
The UFS made a discovery that may have enormous implications for the treatment of diseases in humans.

Since the discovery, the UFS joined forces with the Mayo Clinic in Rochester, US, in the fight against cancer.

In this collective effort, UFS researchers would be able to assist the Mayo team to:
• see how treatment in cancer patients is progressing,
• target treatments more effectively,
• reduce dosages in order to make treatment gentler on the patient,
• track the effectiveness of the chemotherapy drugs used, and
• gain an accurate view of how the cancer is being eliminated.

Prof Lodewyk Kock, Outstanding Professor at the Department of Microbial, Biochemical and Food Biotechnology, and his team incidentally created a technique to use argon gas particles for the first time on biological material to slice open cells to look inside.

The team that supported Prof Kock includes Dr Chantel Swart, Khumisho Dithebe (PhD student), Prof Hendrik Swart (Department of Physics) and Prof Pieter van Wyk (Centre for Microscopy).

Prof Debabrata Mukhopadhyay from the Mayo Clinic in Rochester, US, got to hear about this breakthrough at the UFS and a collaboration between the two institutions was established.

During a visit to the Bloemfontein Campus, Prof Mukhopadhyay explained novel techniques that make use of gold nanoparticles. These particles attach to chemotherapeutic drugs to selectively target cancer cells – dramatically decreasing the side effects to normal human cells.

For these new drugs (coupled to gold nanoparticles) to be accepted into clinical practice, visual and chemical proof is needed, though. This is where the technique developed by the UFS will play a vital role.

With the technique to look inside cells, the composition, location and metabolism of these drugs can be determined. This will aid in a proof of concept for the application of the nano-drugs. Furthermore, it will enable approval for use of these drugs in clinical trials and eventually could revolutionise cancer treatment as a whole.

For video lectures on the technique used, as well as its findings, follow these links:

1. http://vimeo.com/63643628 (Comic version for school kids)

2. http://vimeo.com/61521401 (Detailed version for fellow scientists)

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