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10 September 2020 | Story Rulanzen Martin | Photo Mlungisi Louw
Dr Francois Smith wants his new book, Die kleinste ramp denkbaar, to be a journey to uncover the real disaster.
The new book by Dr Francois Smith from the Department of Afrikaans and Dutch, German and French, Die kleinste ramp denkbaar, is a compelling story about a medical doctor in a typical Free State town. Writing is second nature for Dr Smith, if not first – as evidenced by the success of his debut novel, Kamphoer.

“The success of my previous novel, Kamphoer, greatly contributed to the fact that I was able to get a job at the UFS, especially to teach creative writing,” says Dr Smith, who is currently a Lecturer in Afrikaans and Creative Writing at the University of the Free State (UFS). He does not want to divulge too much about the new book, but says “the story is about a medical doctor in a typical Free State town in whose consulting room a policeman is lying all but senseless from a high fever one morning.” 

The title of the book implies that we all have some kind of disaster fantasy and that the disaster mentioned in the book exists largely in the imagination of the main character – the doctor; that it is something he wants to see. “I am not going to reveal it completely, because in a sense the book is a search for what the disaster is really about,” says Dr Smith. 

For any author, the takeaway message of a book is important. It should touch the lifestyle of the reader in some way. Dr Smith wants Die kleinste ramp denkbaar to say something meaningful about life here in South Africa – “about what makes life here meaningful, or what it is that makes it possible for us to live in the midst of what we experience as a total disaster.” 


Creative Writing a UFS success story

Creative Writing, presented by the Department of Afrikaans and Dutch, German and French, is one of the many success stories that the department is proud of. Dr Smith is part of the formidable team driving the course; also part of the team is Prof Henning Pieterse, a Hertzog Prize-winning poet. 

The success of the course is not only evident from the number of applications, but also from the stream of publications from their stable.  “There will be three this year; in addition to mine, there was also the collection of short stories, Luistervink, by Madré Marais, and later this year Anton Roodt’s novel, Weerlose meganika, will be published,” says Dr Smith.



Die kleinste ramp denkbaar was published by Tafelberg Publishers and is part of the many success stories of the department’s Creative Writing course. 

Watch short video clip below:


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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