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27 January 2022 | Story Andre Damons | Photo iStock

The University of the Free State (UFS) has made steady progress in its research performance over the past five years by increasing its research output, NRF-rated researchers, and internal and external research funding. The university also hosts six South African Research Chairs (SARChI) funded by the National Research Foundation (NRF) / Department of Science and Innovation (DSI), four of which are held by women.

The UFS has also increased its international collaborations with international and regional institutions. Between 2017 and 2020, the university has collaborated with more than 2 534 international institutions and produced 5 792 co-authored publications. Since 2016, there has been a 66% growth in the number of co-authored international collaborations. 

According to Prof Corli Witthuhn, Vice-Rector: Research and Internationalisation, the UFS produced a record number of almost 1 400 research output units in 2020. “I want to thank all our academics and researchers for their productivity in spite of the challenges that we were forced to face due to the pandemic this past year.” 

“The recent DHET Outputs Evaluation Report also indicated that the UFS has produced the most book outputs over the past eight years for the entire South African higher education sector. This is a fantastic achievement of sustained outputs and productivity over an extended period that we can be proud of,” says Prof Witthuhn. 

Growing strong local and global partnerships and networks

According to the latest internal research report, the number of research-related contract grants signed by researchers from the UFS – which remains the largest source of third-stream income at universities – increased to 255 in 2020 compared to the 204 the previous year.

The UFS collaboration partnership included a total of 278 African institutions during the period 2017-2020. Of these, 1 775 co-authored publications were finalised within the following regions (outside South Africa):

- Nigeria, with 47 collaborating institutions and 193 co-authored publications;

- Kenya, with 26 collaborating institutions and 42 co-authored publications;

- Ethiopia, with 24 collaborating institutions and 44 co-authored publications; and

- Egypt, with 14 collaborating institutions and 21 co-authored publications.

The university’s researchers also collaborated with colleagues from the Asia-Pacific region, which included India (158 collaborating institutions), China (106 institutions), Australia (69 institutions), and Pakistan (32 institutions). The majority of the output was within the fields of Physics and Astronomy, as well as Engineering and Material Sciences (from 2017 to 2020).

The European collaborations with 851 institutions resulted in 1 046 co-authored publications from the United Kingdom, Germany, the Netherlands, and Belgium. The co-authored publications increased from 223 in 2017 to 307 in 2020.

The contract research grants from government departments and agencies amounted to R47,2 million in 2020. The Department of Science and Innovation (DSI), (along with its Technology Innovation Agency, TIA), the Petroleum Agency SA, and Water Research Commission (WRC) remain the most important government contributors. Grain SA and the CSIR (including the National Laser Centre) also contributed significantly towards the UFS contract research agenda.

There was an increase in the number of contracts signed in the Faculty of the Humanities during the same period. 
Though the number of signed active research collaboration agreements has declined since 2016 – from 312 in 2016 to 225 in 2020, a total of 1 653 research collaboration agreements were active in 2020. The Office for International Affairs (OIA) supports the creation of a supportive research environment by enabling international engagements of academics, connecting the university with partners through memoranda of understanding, supporting staff and postgraduate student exchanges, and providing data on research internationalisation.

The majority of co-authored publications are within the social sciences field, followed by agricultural and biological sciences. Since 2016, there has been a 66% growth in the number of co-authored international collaborations.

The Afromontane Research Unit (ARU), the flagship research group on the Qwaqwa Campus of the UFS, had its strongest possible year in 2020 since coming into existence in 2015, despite the challenges brought on by the COVID-19 pandemic. The external income unit also increased to more than R40 million.  

Individual research groups continue to grow in size

The ARU, one of the strategic research hubs to focus on – as identified by the UFS senior management – is a strategic research hub and continental leader in African mountain research with a strong focus on research capacity development. The external income was the highest ever for the ARU in a single year, totalling R46 million (although large amounts of this are for external partners working on specific projects). This is a significant increase from 2018 (R5,7 million) and 2019 (R7,6 million).  

Most of the 2020 funding came from four large grants. A very encouraging development was the founding of a Risk and Vulnerability Science Centre (RVSC) in 2020 as part of the DSI Global Change focus theme. The individual research groups of the ARU continue to grow in size, as is evident in the increasing student throughput. Ten postgraduate students graduated in 2020 (up from two in 2019) – two honours, four master’s, and four doctorates, and eight are expected to graduate in 2021. 

Even though the COVID-19 lockdown moved teaching and learning online, research outputs did not taper off as much as expected, with a paper pipeline of 42 papers in 2020 (27 published/accepted, 1 accredited conference proceeding, and 14 submitted manuscripts). This is down by only five compared to 2019 – plus one ARU flagship book. Quality remained high, with an average impact factor (IF) per paper of 2,298, while 48,1% of papers were above IF 2,000 (down from 55,6% in 2019); 25,9% of papers were in the IF 2-3 range, while 37% were in the IF 1-2 range. 

The higher IF publications did taper off somewhat in 2020, with only 14,8% of accepted/published papers in journals with impact factors (IF) >4. The highest IF, however, was 7,319 (up on the 5,667 of 2019, and the second highest recorded in the ARU journey to date), with the second highest being 6,330. An ARU publication was submitted to Science (IF41,845), but although it went for review, it was unfortunately unsuccessful.

ARU strengthens its internationalisation and domestic partnerships

Research and strategic partnership collaborations were greatly enhanced in 2020, with the ARU strengthening its internationalisation and domestic partnerships. ARU activities, intellectual development, partnerships, funding, and opportunities continued to develop and mature in 2020, with the ARU emerging as a global player.

The ARU is well on its way to achieving its vision, mission, and objectives, and can position itself with pride among similar-modelled research groups in Southern Africa and abroad. The ARU is also capturing wider attention, with media coverage of ARU activities represented by 24 media articles in 2020 (up by 7 from 2019).

News Archive

Inaugural lecture: Prof Robert Bragg, Dept. of Microbial, Biochemical and Food Biotechnology
2006-05-17



Attending the inaugural lecture were in front from the left Prof Robert Bragg (lecturer at the Department of Microbial, Biochemical and Food Biotechnology) and Frederick Fourie (Rector and Vice-Chancellor).  At the back from the left were Prof James du Preez (Departmental Chairperson:  Department of Microbial, Biochemical and Food Biotechnology) and Prof Herman van Schalkwyk (Dean: Faculty of Natural and Agricultural Sciences). Photo: Stephen Collett
 

A summary of an inaugural lecture delivered by Prof Robert Bragg at the University of the Free State:

CONTROL OF INFECTIOUS AVIAN DISEASES – LESSONS FOR MAN?

Prof Robert R Bragg
Department of Microbial, Biochemical and Food Biotechnology
University of the Free State

“Many of the lessons learnt in disease control in poultry will have application on human medicine,” said Prof Robert Bragg, lecturer at the University of the Free State’s (UFS) Department of Microbial, Biochemical and Food Biotechnology during his inaugural lecture.

Prof Bragg said the development of vaccines remains the main stay of disease control in humans as well as in avian species.  Disease control can not rely on vaccination alone and other disease-control options must be examined.  

“With the increasing problems of antibiotic resistance, the use of disinfection and bio security are becoming more important,” he said.

“Avian influenza (AI) is an example of a disease which can spread from birds to humans.  Hopefully this virus will not develop human to human transmission,” said Prof Bragg.

According to Prof Bragg, South Africa is not on the migration route of water birds, which are the main transmitters of AI.  “This makes South Africa one of the countries less likely to get the disease,” he said.

If the AI virus does develop human to human transmission, it could make the 1918 flu pandemic pale into insignificance.  During the 1918 flu pandemic, the virus had a mortality rate of only 3%, yet more than 50 million people died.

Although the AI virus has not developed human-to-human transmission, all human cases have been related to direct contact with infected birds. The mortality rate in humans who have contracted this virus is 67%.

“Apart from the obvious fears for the human population, this virus is a very serious poultry pathogen and can cause 100% mortality in poultry populations.  Poultry meat and egg production is the staple protein source in most countries around the world. The virus is currently devastating the poultry industry world-wide,” said Prof Bragg.

Prof Bragg’s research activities on avian diseases started off with the investigation of diseases in poultry.  “The average life cycle of a broiler chicken is 42 days.  After this short time, they are slaughtered.  As a result of the short generation time in poultry, one can observe changes in microbial populations as a result of the use of vaccines, antibiotics and disinfectants,” said Prof Bragg.   

“Much of my research effort has been directed towards the control of infectious coryza in layers, which is caused by the bacterium Avibacterium paragallinarum.  This disease is a type of sinusitis in the layer chickens and can cause a drop in egg product of up to 40%,” said Prof Bragg.

The vaccines used around the world in an attempt to control this disease are all inactivated vaccines. One of the most important points is the selection of the correct strains of the bacterium to use in the vaccine.

Prof Bragg established that in South Africa, there are four different serovars of the bacterium and one of these, the serovar C-3 strain, was believed to be unique to Southern Africa. He also recently discovered this serovar for the first time in Israel, thus indicating that this serovar might have a wider distribution than originally believed.

Vaccines used in this country did not contain this serovar.  Prof Bragg established that the long term use of vaccines not containing the local South African strain resulted in a shift in the population distribution of the pathogen.

Prof Bragg’s research activities also include disease control in parrots and pigeons.   “One of the main research projects in my group is on the disease in parrots caused by the circovirus Beak and Feather Disease virus. This virus causes serious problems in the parrot breeding industry in this country. This virus is also threatening the highly endangered and endemic Cape Parrot,” said Prof Bragg.

Prof Bragg’s research group is currently working on the development of a DNA vaccine which will assist in the control of the disease, not only in the parrot breeding industry, but also to help the highly endangered Cape Parrot in its battle for survival.

“Not all of our research efforts are directed towards infectious coryza or the Beak and Feather Disease virus.  One of my Masters students is currently investigating the cell receptors involved in the binding of Newcastle Disease virus to cancerous cells and normal cells of humans. This work will also eventually lead to a possible treatment of cancer in humans and will assist with the development of a recombinant vaccine for Newcastle disease virus,” said Prof Bragg.

We are also currently investigating an “unknown” virus which causes disease problems in poultry in the Western Cape,” said Prof Bragg.
 
“Although disinfection has been extensively used in the poultry industry, it has only been done at the pre-placement stage. In other words, disinfectants are used before the birds are placed into the house. Once the birds are placed, all use of disinfectants stops,” said Prof Bragg.

“Disinfection and bio security can be seen as the ‘Cinderella’ of disease control in poultry.  This is also true for human medicine. One just has to look at the high numbers of people who die from hospital-acquired infections to realise that disinfection is not a concept which is really clear in human health care,” said Prof Bragg.

Much research has been done in the control of diseases through vaccination and through the use of antibiotics. “These pillars of disease control are, however, starting to crumble and more effort is needed on disinfection and bio security,” said Prof Bragg.

Prof Bragg has been working in close co-operation with a chemical manufacturing company in Stellenbosch to develop a unique disinfectant which his highly effective yet not toxic to the birds.

As a result of this unique product, he has developed the continual disinfection program for use in poultry. In this program the disinfectant is used throughout the production cycle of the birds. It is also used to ensure that there is excellent pre-placement disinfection.

“The program is extensively used for the control of infectious diseases in the parrot-breeding industry in South Africa and the product has been registered in 15 countries around the world with registration in the USA in the final process,” said Prof Bragg.

“Although the problem of plasmid mediated resistance to disinfectants is starting to rear its ugly head, this has allowed for the opening of a new research field which my group will hopefully exploit in the near future,” he said.

 

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