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21 April 2023 | Story Andre Damons | Photo Charl Devenish
Dr Emms
Dr Ayodeji Emmanuel Ogunbayo (right), who graduated this week with a Doctor of Philosophy degree with specialisation in Medical Virology, with his proud supervisor Prof Martin Nyaga, Associate Professor in the UFS Next Generation Sequencing (UFS-NGS).

With respiratory diseases contributing to the highest morbidity and mortality rate in children, and the vast majority of disease aetiology remaining undiagnosed in clinical settings, Dr Ayodeji Emmanuel Ogunbayo hopes his research for his PhD in Medical Virology will help to reduce mortality in children with respiratory infection.

Dr Ogunbayo, commonly known as Dr Emms by his peers, graduated on Thursday (20 April 2023) with a Doctor of Philosophy degree with specialisation in Medical Virology at the University of the Free State (UFS) Faculty of Health Sciences graduation ceremony. The title of his thesis was Metagenomics of the respiratory RNA virome of children in the Free State. His supervisor was Prof Martin Nyaga, Associate Professor in the UFS Next Generation Sequencing (UFS-NGS) and Director of the WHO Collaborating Centre (WHO CC).

“While clinical metagenomics next-generation sequencing (mNGS), which is an upcoming method, has the potential to revolutionise infection diagnosis and management in children, there is a dearth of information on its clinical applicability in Africa. This is the knowledge that guided the inception of this research,” says Dr Ogunbayo.

Project came at the right time

He commenced with his PhD in Medical Virology in 2019, which was centred on the applicability of mNGS in severe acute respiratory infection (SARI) in children and deciphering the children’s respiratory virome in health and disease, a project which was the first of its kind in Africa.

According to him, the project was conceived before the COVID-19 pandemic, however, despite the challenges encountered due to lockdown measures, the project came at the right time as it was able to address several profound effects of the pandemic such as COVID-19 on the dynamics of transmission of respiratory viruses and ultimately its effect on children’s health. During his PhD study, he published four manuscripts in highly reputable journals including the most recent one which was accepted in Journal of Medical Virology (JMV)  an impressive impact factor of 20.693.

The findings from this study included a validated and robust workflow to recover respiratory RNA viruses from clinical samples, according to the graduation programme. The established workflow was adapted to decipher children’s respiratory virome composition in health and disease, with a degree of heterogeneity, while simultaneously establishing the clinical diagnostic applicability of mNGS and, more importantly, the increased utility of dual-triple mNGS analysis tools in robust detection of viral pathogens in SARI.

His hope for the research

Dr Ogunbayo says: “This research generated vast pioneering information and data in Africa that could guide and influence policy in the adoption of clinical metagenomics, especially in cases where conventional methods of diagnosis yielded no results. Hopefully, this could lessen mortality due to respiratory infection in children.

Before studying in the field of medical Microbiology and Virology, he wanted to be a psychiatric nurse, but instead chose his current field of study because of his interest in the microbial world and pathology.

“It’s a feeling one cannot really put into words. A part of me feels like it is a ‘dream come true’ and another part of me feels like ‘this is a milestone achieved, but it’s just a stepping stone to further milestones to be achieved’.

“What is next is for me to dive into the world of policy-influencing research, give back to the academic community through student supervision, and work on my journey to becoming an emerging researcher. This is the reason I have taken a postdoctoral position at the UFS-NGS Unit under the mentorship of Prof Martin Nyaga.”

Prof Nyaga says: “Looking back at Emmanuel’s doctoral journey, it brought out the best in him in every aspect of the study. Longitudinal studies are hectic in the sampling phase, and all the ethical clearances that a study must achieve prior to beginning the sampling and the laboratory work can be very frustrating. Soon after his study was approved, the pandemic lockdown level 5 rules were applied, which meant he had to pause on the study. However, his focus, positive mindset and his ability to work in close consultation with his supervisor enabled him to finish this study in the best way possible. I am very proud of him.”

News Archive

UFS receives R10 million in student funding from Absa
2017-06-19

 

Description: UFS receives R10 million in student funding from Absa Tags: UFS receives R10 million in student funding from Absa

From the left: Asive Dlanjwa (UFS SRC) Prof Francis Petersen, Fikemini Dlamini,
Bertie Smith and Lesley Afrika (student beneficiary 2016-2017)

 

In support of building a more equitable and prosperous Africa, and in response to the plight of students who lack financial aid at universities across the country, Absa Bank handed over a cheque of R10 million to the University of the Free State (UFS) at a ceremony held on the Bloemfontein Campus on 13 June 2017 by the office of Institutional Advancement. The allocation of these funds will assist students who meet the bursary programme criteria (proven financial need, students who are from households with a combined income of less than R1 million per annum, with an academic average of 55% or higher).

Corporate and higher education collaborate
Speaking at the event, Rector and Vice-Chancellor of the UFS Prof Francis Petersen highlighted the important role corporates play in collaborating with educational institutions to help support future professionals who are the future builders of the economy and will later lead industry. “Absa and the UFS enjoy a good relationship and it is our hope that this bursary programme will grow from strength to strength,” he said.

In 2016 alone, Absa Bank disbursed R12 million towards settling outstanding fees for 439 students in four faculties of the UFS. In 2017 the funds will be allocated similarly to cover financial needs of qualifying students. Mr Bertie Smith, Absa Management Executive: Central Region said: “The university plays an important role in building future leaders and Absa’s strategy of shared growth supports the focus on education.”

Responding to a greater socioeconomic need
The event was attended by staff of the UFS and delegates from the Absa group, as well as students who were beneficiaries of the Absa Bursary Fund in 2016. Mr Fikemini Dlamini, Absa Head: Public Sector Business Banking, said the bursary programme was born out of the growing need to fund and develop the education of young people, and is a response to the outcry from students across the country in the “Fees Must Fall” movement. He said: “Educating one young person has a knock-on effect that has the potential to alleviate poverty in many families and communities around us.”



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