Full-length articles

Le Roux M.C., Hoosen A.A.  “Quantitative Real-Time Polymerase Chain Reaction for the Diagnosis of Mycoplasma genitalium infection in South African men with and without symptoms of Urethritis”. Sexually transmitted Diseases. 2017:44(1):18-21.

Hardie D.R., Korsman S.N., Hsiao N-Y., Morobadi M.D., Vawda S., Goedhals D. “Contamination with HIV antibody may be responsible for false positive results in specimens tested on automated platforms running HIV 4th generation assays in a region of high HIV prevalence.”  PloS One. 2017; 12(7):e0182167.

Steegen K., Bronze M., Papathanasopoulos M.A., van Zyl G., Goedhals D., Variavo E., MacLeod W., Sanne I., Stevens W.S., Carmona S.  “HIV-1 antiretroviral drug resistance patterns in patients failing NNRTI-based treatment: results from a national survey in South Africa”. J. Antimicrob. Chemother. 2017; 72:210-219.

Burt F.J, Chen W., Miner J.J., Lenschow D.J., Merits A., Schnettler E., Kohl A., Rudd P.A., Taylor A., Herrero L.J., Zaid A., Ng L.F.P. “Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen”. Lancet Infect Dis. 2017; 17(4):e107-e117.

Rhee S-Y., Varghese V., Holmes S.P., Van Zyl G.U., Steegen K., Boys M.A., Cooper D.A., Nsanzimana S., Saravanan S., Charpentier C., de Oliveira T., Etiebet M-A.A., Garcia F., Goedhals D., Gomes P., Günthard.H.F., Hamers R.L., Hoffmann C.J., Hunt G., Jiamsakul A., Kaleebu P.,  Kanki P., Kantor R., Kerschberger B., Marconi V.C., Ndahimana J.D., Ndembi N., Ngo-Giang-Huong N., Rokx C., Santoro M.M.,  Schapiro J.M., Schmidt D., SEU l., Sigaloff K.C.E., Sirivichayakul S., Skkosana L., Sunpath H., Tang M., Yang C., Carmona S., Gupta R.K., Shafer R.W.  “Mutational Correlates of Virological Failure in individuals receiving a WHO-Recommended Tenofovir-cantaining first-line regimen: An international collaboration”. EBioMedicine. 2017; 18:225-235.

Goedhals D., Paweska Janusz T., Burt F.J.  “Long-lived CD8+ T cell responses following CRIMEAN-Congo haemorrhagic fever virus infection”.  PloS Negl Trop Dis. 2017; 11(12):e0006149.



Full-length articles

Jelen M.M., Chen Z., Kocjan B.J., Hošnjak L., Burt F.J., Chan P.K., Chouhy D., Combrinck C.E., Estrade C., Fiander A., Garland S.M., Giri A.A., González J.V., Gröning A., Hibbitts S., Luk T.N., Marinic K., Matsukura T., Neumann A., Oštrbenk A, Picconi M.A., Sagadin M., Sahli R., Seedat R.Y., Seme K., Severini A., Sinchi J.L., Smahelova J., Tabrizi S.N., Tachezy R., Tohme Faybush S., Uloza V., Uloziene I., Wong Y.W., Židovec Lepej S., Burk R.D., Poljak M. Global Genomic Diversity of Human Papillomavirus 11 Based on 433 Isolates and 78 Complete Genome Sequences. J Virol. 2016;90(11):5503-5513.

Seedat R.Y., Combrinck C.E., Bester P.A., Lee J.Y., Burt F.J. Determination of the complete genome and functional analysis of HPV6 isolate VBD19/10 from a patient with aggressive recurrent respiratory papillomatosis. Epidemiol. Infect. 2016;144(10): 2128-2135.

Weidmann M., Avsic-Zupanc T., Bino S., Bouloy M., Burt F.J., et al.  Biosafety standards for working with Crimean-Congo haemorrhagic fever virus. J Gen Virol. 2016;97(11):2799-2808.

Atkinson R., Burt F.J., Rybicki E.P., Meyers A.E. Plant-produced Crimean-Congo haemorrhagic fever virus nucleoprotein for use in indirect ELISA. 2016. J Virol Methods. 2016;236:170-177.

Steegen K., Carmona S., Bronze M., Papathanasopoulos M.A., van Zyl G., Goedhals D., MacLeod W., Sanne I., Stevens W.S. Moderate Levels of Pre-Treatment HIV-1 Antiretroviral Drug Resistance Detected in the First South African National Survey. Plos One. 2016;11(12):e0166305.

Jooste P., van Zyl A., Adland E., Daniels S., Hattingh L., Brits A., Wareing S., Goedhals D., Jeffery K., Andersson M., Goulder P., Matthews P.C.  Screening, characterisation and prevention of Hepatitis B virus (HBV) co-infection in HIV-positive children in South Africa.  J. Clin. Virol. 2016;85:71-74.

Steegen K., Bronze M., Papathanasopoulos M.A., van Zyl G., Goedhals D., van Vuuren C., Macleod W., Sanne I., Stevens W.S., Carmona S.C.  Prevalence of antiretroviral drug resistance in patients who are not responding to protease inhibitor-based treatment: results from the first national survey in South Africa.  J. Infect. Dis. 2016;214(12):1826-1830.

TenoRes Study Group (including Goedhals D., Bester P.A.).  Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study. Lancet Infect. Dis. 2016;16(5):565-575.

Van der Spoel van Dijk A.,  Makhoahle P.M., Rigouts L.,  Baba K.  Diverse Molecular Genotypes of Mycobacterium tuberculosis Complex Isolates Circulating in the Free State, South Africa. Int. J. Microbiol. 2016;2016:6572165.

Rukasha I., Said H.M.,  Omar S.V., Koornhof H.,  Dreyer A.W., Musekiwa A., Moultrie H., Hoosen A.A.,  Kaplan G., Fallows D.,  Ismail N. Correlation of rpoB Mutations with Minimal Inhibitory Concentration of Rifampin and Rifabutin in Mycobacterium tuberculosis in an HIV/AIDS Endemic Setting, South Africa. Front. Microbiol 2016;7:1947.




Full-length articles

Goedhals D., Bester P.AA., Paweska J.T., Swanepoel ., Burt F.J. “Comparative Analysis of the L, M, and S RNA Segments of Crimean–Congo Haemorrhagic Fever Virus Isolates from Southern Africa.” J. Med. Virol. 2015; 87(5):717–724.

Goedhals D., Paweska J.T., Burt F.J.  “Identification of human linear B-cell epitope sites on the envelope lycoproteins of Crimean-Congo haemorrhagic fever virus.”Epidemiol. Infect. 2015; 143(7), 1451–1456.

Chapters in books

Burt FJ, Goedhals D. (2015). Crimean-Congo haemorrhagic fever an emerging virus and reemerging pathogen.  In: A. Singh (Ed.), Zoonoses: Infections affecting humans and animals – A focus on public health aspects.  Springer Publishers.



Goedhals D., Paweska J.T., Swanepoel R., Bester P.A., Burt F.J.  Next generation sequencing of southern Africa Crimean-Congo haemorrhagic fever virus isolates reveals a high frequency of M segment re-assortment.  Epidemiol Infect 2014; 142: 1952–1962.

Mathengtheng L., Burt F.J.  Use of envelope domain III protein for detection and differentiation of flaviviruses in the Free State Province, South Africa.  Vector Borne Zoonotic Dis 2014; 14: 261-271.

Jelen M.M., Chen Z., Kocjan B.J., Burt F.J., et al.  Global genomic diversity of human papillomavirus type 6 (HPV6) based on 724 isolates and 190 complete genome sequences. J Virol 2014; 88:7307-7316.

Goedhals D., Paweska J.T., Burt F.J.  Identification of linear B-cell epitopes on the envelope glycoproteins of Crimean-Congo haemorrhagic fever virus. Epidemiol Infect.  2014 Accepted and in press Sep 4:1-6. [Epub ahead of print].

Manasa J., Lessells R., Rossouw T., Naidu K.,  Van Vuuren C., Goedhals D., et al.  Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database:supporting patient management, surveillanceand research in southern Africa.  Database, Vol. 2014, Article ID bat082, doi:10.1093/database/bat082.

Burt F.J., Goedhals D., Mathengtheng L.  Arboviruses in southern Africa, are we missing something?  Future Virol 2014; 9:993-1008.

Rangunwala A., Samudzi R.R., Burt F.J.  Detection of IgG antibody against Crimean-Congo haemorrhagic fever virus using ELISA with recombinant nucleoprotein antigens from genetically diverse strains. Epidemiol Infect 2014; 142: 2147-2154.

Hallbauer U.M., Atkins M.D., Tiedt N.J., Butler I.R., Pieters M., Elliott E., Joubert G., Seedat R.Y. Co-morbidities in children presenting with chronic suppurative otitis media-a South African study.  J Trop Pediatr 2014; 60: 198-202.



Burt F.J., Combrinck C.E., Seedat R.Y. FRET-based detection and genotyping of  HPV-6 and HPV- 11 causing recurrent  respiratory papillomatosis. J Virol Methods 2013; 189: 271-276.


Seedat R.Y., Combrinck C.E., Burt F.J. HPV associated with recurrent respiratory papillomatosis. Future Virology 2013; 8: 1-16.


Burt F.J., Samudzi R.R., Randall C., Pieters D., Vermeulen J., Knox C.M. Human defined antigenic region on the nucleoprotein of Crimean-Congo hemorrhagic fever virus identified using truncated proteins and a bioinformatics approach.  J Virol Methods 2013; 193: 706-712.


Goedhals D., Scott Lesley E., Moretti Serena, Cooper Mark A., Opperman J.L., Rossouw I. Evaluation of the use of plasma preparation tubes for HIV viral load testing on the COBAS AmpliPrep/COBAS TaqMan HIV-version 2.1.  J Virol Methods 2013; 18: 248-250.

Published commentary


Burt F.J., Chen W., Mahalingham S. Chikungunya virus and arthritic disease: mechanism and potential risk factor for severe disease.  Lancet Infect Dis 2014; 14:789-790.




Goedhals D, Rossouw I, Hallbauer U, Mamabolo M, de Oliveira T.  The tainted milk of human kindness.  The Lancet.  2012; 38: 702.


Keddy K.H., Sooka A., Crowther-Gibson P., Quan V., Meiring S., Cohen C., Nana T., Sriruttan C., Seetharam S., Hoosen A., Naicker P., Elliott E., Haffejee S., Whiteslaw A., Klugman K.P., for the Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GEMS-SA).  Systemic shigellosis in South Africa.  Clin Infect Dis 2012; 54: 1448-1454.


Meiring SM, Webb MJ, Goedhals D, Louw VJ.  HIV-associated thrombotic thromboytopenic pupura - what we know so far. Eur J  Oncol. 2012; 8: 89 - 91.


Klovirpris H, Harndahl M, Leslie A, Carlson J, Ismail N, van der Stok M, Huang K, Chen F, Riddell L, Steyn D, Goedhals D, Jansen Van Vuuren JC, Frater J, Walker B, Carrington M, Ndung'u T, Buus S, Goulder P. HIV Control through a single nucleotide on the HLA_B Locus. J Virol. 2012; 86: 11493-11500. 


Matthews P., Listgarten J., Carlson J., Payne R., Huang K., Frater J., Goedhals D., Steyn D., Jansen Van Vuuren J.C., Paioni P., Jooste P.L, Ogwu A, Shapiro R, Mncube Z., Ndung’u T., Walker B., Heckerman D., Gouder P.  Co-operative additive effects between HLS Alleles in control of HIV-1.  PloS One. 2012; 7: 1-7.


Combrinck C.E., Seedat R.Y., Randall C., Roodt Y., Burt F.J. Novel HPV-6 variants of human papillomavirus causing recurrent respiratory papillomatosis in southern Africa. Epidemiol Infect. 2012; 140: 1095-101.

Samudzi R.R., Leman P.A., Paweska J.T., Swanepoel R., Burt F.J. Bacterial expression of Crimean-Congo hemorrhagic fever virus nucleoprotein and its evaluation as a diagnostic reagent in an indirect ELISA. J Virol Methods 2012; 179: 70-76.


Burt F.J., Rolph M., Rulli N.E., Mahalingam S Heise MT. Chikungunya: a re-emerging virus. The Lancet. 2012; 379: 662-671.

Carroll S.A., Towner J.S., Sealy T.K., McMullan L.K., Khristova M.L., Burt F.J., Swanepoel R., Rollin P.E., Nichol S.T. Molecular evolution of viruses of the family Filoviridae based on 97 whole genome sequences. J Virol. 2012; 87: 2608-2626.

Bamford C., Bonorchis K., Ryan A., Simpson J., Elliott E., Hoffmeyer R., Naicker P., Ismail N., Mbelle N., Nchabeleng N., Nana T., Sriruttan C., Seetharam S., Wadula J.  Antimicrobial susceptibility patterns of selected bacteraemic isolates from South African public sector hospitals, 2010.  J Epidemiol. 2012; 26: 243-250.

Goedhals D., Scott L., Moretti S.A.,  Opperman W.J.L., Rossouw I. Evaluation of the use of plasma preparation tubes for HIV viral load testing on the COBAS TaqMan HIV-1 version 2.0.  J Virol Methods 2012; 187: 248-250.

Chapter in book


Huang K-HG, Fryer H, Goedhals D, Jansen van Vuuren J.C., Frater J.  (2012). HIV Drug Resistance in Sub-Saharan Africa – Implications for Testing and Treatment.  In Ricardo Sobhie Diaz (Ed.), HIV Testing (109-132). InTech.


Grolla A., Jones S.M., Fernando L., Strong J.E., Ströher U., Möller P., Paweska J.T., Burt F.J., Pablo Palma P., Sprecher A., Formenty P., Roth C., Feldmann H.  The use of a mobile laboratory unit in support of patient management and epidemiological surveillance during the 2005 Marburg Outbreak in Angola.  PLoS Negl Trop Dis. 2010; 5: e1183.


Combrinck C.E., Seedat R.Y., Randall C., Roodt Y., Burt F.J. Novel HPV-6 variants of human papillomavirus causing recurrent respiratory papillomatosis in southern Africa. Epidemiol Infect. 2011; 30:1-7.

Jones P., Cordonnier N., Mahamba C., Burt F.J., Rakotovao F., Swanepoel R., André     C., Dauger S., Bakkali Kassimi L. Encephalomyocarditis virus mortality in   semi-wild bonobos (Pan panicus).  J Med Primatol. 2011; 40: 157-63.

Burt F.J. Laboratory diagnosis of Crimean–Congo hemorrhagic fever virus infections.  Future Virology. 2011;  6: 831-841.

Huang K-H.G., Goedhals D., Carlson J.M, Brockman M.A., Mishra S., Brumme Z.L.,  Hickling S.,  Tang C.S.W, Miura T, Seebregts C., Heckerman D., Ndung’u T.,  Walker B,  Klenerman P, Steyn D, Goulder P, Philips R, Bloemfontein-Oxford Collaborative Group, Jansen van Vuuren C, Frater J. Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations.  PLoS ONE. 2011; 6: e19018.


Matthews P.C., Adland E, Listgarten J,  Leslie A., Mkhwanazi N., Carlson J.M., Harndahl M.,  Stryhn A., Payne R.P., Ogwu A., Huang K-H. G., Frater J.,      Paioni P., Kloverpris H, Jooste P, Goedhals D,  Jansen van Vuuren C., Steyn D., Riddell L., Chen F., Luzzi G., Balachandran T., Ndung’u T., Buus O., Carrington M., Shapiro R., Heckerman D., Goulder P.J.R.  HLA-A*7401 – Medicated Control of HIV Viremia is independent of its linkage disequilibrium with HLA-B*6703. J Immunol. 2011; 186: 5675-5686.


Rossouw I., Goedhals D,  van der Merwe J.,  Stallenberg V.,  Govender N.  A rare, fatal case of invasive spinal aspergillosis in an antiretroviral-naïve, HIV-infected man with pre-existing lung colonization. J Medical Microbiol 2011; 60:1534-1538.


Hallbauer U.M., Goosen Y., Pieters M. An outbreak of pertussis in Bloemfontein, South Africa, 2008-2009. South African Family Practice (Geneeskunde:  The Medicine Journal), 2011; 53: 495-500.


Burt F.J., Seedat R.Y., Thukane M., Jansen A.C., Rossouw I., Goedhals D.  HPV types causing juvenile recurrent laryngeal papillomatosis in South Africa. Int J Pediatr Otorhinolaryngo 2010; 74: 255-259.


Burt F.J., Kondiah K., Swanepoel R., Janusz T., Paweska J. A Simple-Probe real-time PCR assay for genotyping reassorted and non-reassorted isolates of      Crimean-Congo hemorrhagic fever virus in southern Africa. J Virol Methods. 2010; 169: 34-38.



Venter M, Burt FJ, Blumberg L, Fickl H, Paweska J, Swanepoel R. (2009). Cytokine induction after laboratory-acquired West Nile virus infection. N Eng J Med 360:1260-1262.



Goedhals D, Kriel J, Hertzog ML, Janse van Rensburg MN.  Human cytomegalovirus infection in infants with prolonged neonatal jaundice.  J Clin Virol 2008; 43: 216-218.


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