Prof Dominique Goedhals
Position
Senior Lect/Pathologist
Department
School of Pathology
Address
GN
Medical Microbiology
IB G23
UFS
Telephone
051 4052834
Office
Information

Short CV

Qualifications
MBChB University of the Free State, 1999
DTM&H University of the Witwatersrand, 2004
MMed (Virol Path) University of the Free State, 2005
PhD (Virol) University of the Free State, 2014

Academic teaching responsibilities
MBChB
MMed (Virology, Microbiology)
MMed Sc
PhD

Research interests
Crimean-Congo haemorrhagic fever virus; HIV and opportunistic infections

Publications

Publications in peer reviewed journals

  1. Goedhals D, Kriel J, Hertzog ML, Janse van Rensburg MN.  Human cytomegalovirus infection in infants with prolonged neonatal jaundice.  J Clin Virol 2008; 43: 216-218.    
  2. Huang KHG, Goedhals D, Fryer H, van Vuuren C, Katzourakis A, De Oliviera T, Brown H, Cassol S, Seebregts C, McLean A, Klenerman P, Phillips R, Frater J.  Prevalence of HIV drug-associated mutations in pre-therapy patients in the Free State, South Africa.  Antiviral Therapy, 2009; 14: 975-984.  
  3.  Seedat RY, Thukane M, Jansen AC, Rossouw I, Goedhals D, Burt FJ.  HPV types causing juvenile recurrent laryngeal papillomatosis in South Africa.  Int J Pediatr Otorhinolaryngol, 2010 Mar; 74 (3): 255-9.  
  4. Huang KHG, Goedhals D, Carlson JM, Brockman MA, Mishra S, Brumme ZL, Hickling S, Tang CSW, Miura T, Seebregts C, Heckerman D, Ndung’u T, Walker B, Klenerman P, Steyn D, Goulder P, Phillips, R, Bloemfontein-Oxford Collaborative Group,  van Vuuren C, Frater J. Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations.  PLOS ONE, 2011; 6 (4): e19018.
  5. Matthews PC, Adland E, Listgarten J, Leslie A, Mkhwanazi N, Carlson JM, Harndahl M, Stryhn A, Payne RP, Ogwu A, Huang KHG, Frater J, Paioni P, Kloverpris H, Jooste P, Goedhals D, van Vuuren C, Steyn D, Riddell L, Chen F, Luzzi G, Balachandran T, Ndung’u T, Buus S, Carrington M, Shapiro R, Heckerman D, Goulder PJR.  HLA_A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703.  J Immunol 2011; 186: 5675-5686.    
  6. Rossouw I, Goedhals D, van der Merwe J, Stallenberg BS, Govender NP. A rare, fatal case of invasive spinal aspergillosis in an antiretroviral-naïve, HIV-infected  man with pre-existing lung colonization.  J Med Microbiol 2011; 60(Pt 10):1534-1538.  
  7. Meiring M, Webb M, Goedhals D, Louw V.  HIV-associated thrombotic thrombocytopeni purpura – What we know so far.  European Oncology & Haematology 2012; 8(2):89-91.  
  8. Goedhals D, Rossouw I, Hallbauer U, Mamabolo M, de Oliveira T.  The tainted milk of human kindness.  Lancet 2012 Aug 18; 380(9842):702.  
  9. Kløverpris HN, Harndahl M, Leslie AJ, Carlson JM, Ismail N, van der Stok M, Huang KH, Chen F, Riddell L, Steyn D, Goedhals D, van Vuuren C, Frater J, Walker BD, Carrington M, Ndung’u T, Buus T, Goulder P.  HIV control through a single nucleotide on the HLA-B locus.  J Virol 2012; 86(21):11493-11500.    
  10. Matthews PC, Listgarten J, Carlson JM, Payne R, Kuan-Hsiang GH, Frater J, Goedhals D, Steyn D, van Vuuren C, Paioni P, Jooste P, Ogwu A, Shapiro R, Mncube Z, Ndung’u T, Walker BD, Heckerman D, Goulder PJR.  Co-operative additive effects between HLA alleles in control of HIV-1.  PLoS One 2012; 7(10):e47799.    
  11. Goedhals D, Scott LE, Moretti S, Cooper MA, Opperman WJL, Rossouw I.  Evaluation of the use of plasma preparation tubes for HIV viral load testing on the COBAS AmpliPrep/COBAS TaqMan HIV-1 version 2.0.  J Virol Methods 2013; 187(2):248-250.
  12. Manasa J, Lessells R, Rossouw T, Naidu K, van Vuuren C, Goedhals D, van Zyl G, Bester A, Skingsley A, Stott K, Danaviah S, Chetty T, Singh L, Moodley P, Iwuji C, McGrath N, Seebregts CJ, de Oliveira T.  Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa.  Database 2014 Feb 6;2014:bat082.
  13. Goedhals D, Bester PA, Paweska JT, Swanepoel R, Burt FJ.  Next-generation sequencing of southern African Crimean-Congo haemorrhagic fever virus isolates reveals a high frequency of M segment reassortment.  Epidemiol Infect 2014; 142(9):1952-1962.
  14. Burt FJ, Goedhals D, Mathengtheng L.  Arboviruses in southern Africa, are we missing something?  Future Virol 2014; 9(11):993-1008.
  15. Goedhals D, Paweska JT, Burt FJ.  Identification of human linear B-cell epitope sites on the envelope glycoproteins of Crimean-Congo haemorrhagic fever virus.  Epidemiol Infect 2015; 143(7):1451-1456.
  16. Goedhals D, Bester PA, Paweska JT, Swanepoel R, Burt FJ.  Comparative analysis of the L, M and S RNA segments of Crimean-Congo haemorrhagic fever virus isolates from southern Africa.  J Med Virol 2015; 87(5):717-724.
  17. The TenoRes Study Group.  Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study.  Lancet ID 2016; 16(5):565-575.
  18. Steegen K, Bronze M, Papathanasopoulos MA, van Zyl G, Goedhals D, van Vuuren C, Macleod W, Sanne I, Stevens WS, Carmona SC.  Prevalence of antiretroviral drug resistance in patients failing protease inhibitor-based treatment: results from the first national survey in South Africa.  J Infect Dis 2016;214(12):1826-1830.
  19. Jooste P, van Zyl A, Adland E, Daniels S, Hattingh L, Brits A, Wareing S, Goedhals D, Jeffery K, Andersson M, Goulder P, Matthews PC.  Screening, characterisation and prevention of hepatitis B virus (HBV) co-infection in HIV-positive children in South Africa.  J Clin Virol 2016; 85:71-74.
  20. Steegen K, Carmona S, Bronze M, Papathanasopoulos MA, van Zyl G, Goedhals D, MacLeod W, Sanne I, Stevens WS.  Moderate levels of pre-treatment HIV-1 antiretroviral drug resistance detected in the first South African national survey.  PLoS One 2016;11(12):e0166305.
  21. Steegen K, Bronze M, Papathanasopoulos MA, van Zyl G, Goedhals D, Variava E, MacLeod W, Sanne I, Stevens WS, Carmona S.  HIV-1 antiretroviral drug resistance patterns in patients failing NNRTI-based treatment: results from a national survey in South Africa.  J Antimicrob Chemother 2017;72(1):210-219.
  22. Rhee SY, Varghese V, Holmes SP, Van Zyl GU, Steegen K, Boyd MA, Cooper DA, Nsanzimana S, Saravanan S, Charpentier C, de Oliveira T, Etiebet MA, Garcia F, Goedhals D, Gomes P, Günthard HF, Hamers RL, Hoffmann CJ, Hunt G, Jiamsakul A, Kaleebu P, Kanki P, Kantor R, Kerschberger B, Marconi VC, D`amour Ndahimana J, Ndembi N, Ngo-Giang-Huong N, Rokx C, Santoro MM, Schapiro JM, Schmidt D, Seu L, Sigaloff KC, Sirivichayakul S, Skhosana L, Sunpath H, Tang M, Yang C, Carmona S, Gupta RK, Shafer RW. Mutational correlates of virological failure in individuals receiving a WHO-recommended tenofovir-containing first-line regimen: an international collaboration.  EBioMedicine 2017 Apr;18:225-235.
  23. Hardie DR, Korsman SN, Hsiao NY, Morobadi MD, Vawda S, Goedhals D.  Contamination with HIV antibody may be responsible for false positive results in specimens tested on automated platforms running HIV 4th generation assays in a region of high HIV prevalence. PLoS One 2017;12(7):e0182167.
  24. Goedhals D, Paweska JT, Burt FJ. Long-lived CD8+ T cell responses following Crimean-Congo haemorrhagic fever virus infection. PLoS Negl Trop Dis 2017;11(12):e0006149.
  25. Murray LW, Satti I, Meyerowitz J, Jones M, Willberg CB, Ussher JE, Goedhals D, Hurst J, Phillips RE, McShane H, Vuuren CV, Frater J.  Human immunodeficiency virus impairs Th1 and Th17 Mycobacterium tuberculosis-specific T-cell responses. J Infect Dis 2018;217(11):1782-1792.
  26. Vawda S, Goedhals D, Bester PA, Burt F.  Seroepidemiologic survey of Crimean-Congo hemorrhagic fever virus in selected risk groups, South Africa.  Emerg Infect Dis 2018;24(7):1360-1363.
  27. Sekee TR, Burt FJ, Goedhals D, Goedhals J, Munsamy Y, Seedat RY. Human papillomavirus in head and neck squamous cell carcinomas in a South African cohort.  Papillomavirus Res 2018;6:58-62.
  28. Mokaya J, McNaughton AL, Hadley MJ, Beloukas A, Geretti AM, Goedhals D, Matthews PC.  A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: A call for urgent action.  PLoS Negl Trop Dis 2018;12(8):e0006629.
  29. Bester PA, De Vries A, Riekert S, Steegen K, van Zyl G, Goedhals D.  PhyoPi: an affordable, purpose built phylogenetic pipeline for the HIV drug resistance testing facility.  PLoS One 2019;14(3):e0213241.
  30. Mokaya J, Burn EAO, Tamandjou CR, Goedhals D, Barnes EJ, Andersson M, Pinedo-Villanueva R, Matthews PC.  Modelling cost-effectiveness of tenofovir for prevention of mother to child transmission of hepatitis B virus (HBV) infection in South Africa.  BMC Public health 2019;19(1):829.
  31. Palmer DS, Turner I, Fidler S, Frater J, Goedhals D, Goulder P, Huang KG, Oxenius A, Phillips R, Shapiro R, Vuuren CV, McLean AR, McVean G.  Mapping the drivers of within-host pathogen evolution using massive data sets. Nat Commun 2019;10(1):3017.
  32. Phetsouphanh C, Aldridge D. Marchi E, Munier CML, Meyerowitz J, Murray L, van Vuuren C, Goedhals D, Fidler S, Kelleher A, Klenerman P, Frater J.  Maintenance of functional CD57+ cytolytic CD4+ T cells in HIV+ elite controllers.  Front Immunol 2019;10:1844.
  33. Bulane A, Goedhals D, Seedat RY, Goedhals J, Burt F.  Human papillomavirus DNA in head and neck squamous cell carcinomas in the Free State, South Africa.  J Med Virol 2020;92(2):227-233.
  34. Mathengtheng L, Goedhals D, Bester PA, Goedhals J, Burt FJ. Persistence of Crimean-Congo hemorrhagic fever virus RNA.  Emerg Infect Dis 2020;26(2):385-387. (Joint first author)
  35. McNaughton Al, Lourenço J, Bester PA, Mokaya J, Lumley SF, Obolski U, Forde D, Maponga TG, Katumba KR, Goedhals D, Gupta S, Seeley J, Newton R, Ocama P, Matthews PC.  Hepatitis B virus seroepidemiology data for Africa: Modelling intervention strategies based on a systematic review and meta-analysis.  PLoS Med 2020;17(4):e1003068.
  36. Maponga TG, McNaughton AL, van Schalkwyk M, Hugo S, Nwankwo C, Taljaard J, Mokaya J, Smith DA, van Vuuren C, Goedhals D, Gabriel S, Andersson MI, Preiser W, van Rensburg C, Matthews PC. Treatment advantage in HBV/HIV coinfection compared to HBV monoinfection in a South African cohort. J Infect 2020;81(1):121-130.
  37. Msomi N, Mlisana K, de Oliveira T; Network for Genomic Surveillance in South Africa writing group. A genomics network established to response rapidly to public health threats in South Africa.  Lancet Microbe 2020;1(6):e229-e230.
  38. Downs LO, Vawda S, Bester PA, Lythgoe KA, Wang T, McNaughton AL, Smith DA, Maponga T, Freeman O, Varnai KA, Davies J, Woods K, Fraser C, Barnes E, Goedhals D, Matthews PC. Bimodal distribution and set point HBV DNA viral loads in chronic infection: retrospective analysis of cohorts from the UK and South Africa. Wellcome Open Res 2020;5:113.

Book chapters

  1. Huang K-HG, Fryer H, Goedhals D, van Vuuren C, Frater J.  (2012). HIV Drug Resistance in Sub-Saharan Africa – Implications for Testing and Treatment.  In: Ricardo Sobhie Diaz (Ed.), HIV Testing (109-132). InTech.
  2. Burt FJ, Goedhals D. (2015). Crimean-Congo haemorrhagic fever an emerging virus and reemerging pathogen.  In: A. Singh (Ed.), Zoonoses: Infections affecting humans and animals – A focus on public health aspects.  Springer Publishers

Publications (Short List)


Research


Area(s) of Interest


Courses Presented


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