Dr Charlene Marais
Position
Senior Lecturer
Department
Chemistry
Address
Chemistry
IB 48
UFS
R9747
Telephone
051 401 7292
Office
Chemistry Building 202
Information

Short CV

 

BSc (UFS), BSc (Hon) (UFS), MSc (UFS), PhD (Chemistry) (UFS)

 

Charlene Marais (née Rabe) completed both her M.Sc. and Ph.D. degrees at the University of the Free State. These projects entailed the isolation, identification and synthesis of metabolites from rooibos tea (Aspalathus linearis) and also a biomimetic investigation of the fermentation of rooibos.  Charlene has worked on a SASOL project as post-doctoral fellow, as a Senior Medical Scientist at the Department of Pharmacology (UFS), was a facilitator and coordinator in the Access Programmes and, since 2008, co-supervisor and supervisor of various M.Sc. and Ph.D. projects in Industrial Process Chemistry, homogeneous catalysis and organic synthesis in general.

 

Her current research focuses on the modification of industrial and other catalytic methodology (e.g. hydroformylation, olefin metathesis, transfer hydrogenation) for the preparation of flavonoids, stilbenoids and other compounds with potential anti-cancer, anti-HIV and antimalarial activities. The reaction mechanisms are investigated and the reaction conditions optimized by analysis of the reaction mixtures and products by different NMR (nuclear magnetic resonance spectroscopy) techniques, MALDI-TOF mass spectrometry (MS), gas chromatography (GC), GC-MS, infrared spectroscopy and X-ray crystallography. 

 

 

 

Publications

Phenolic metabolites from rooibos tea (Aspalathus linearis).

C. Rabe, J.A. Steenkamp, E. Joubert, J.F.W. Burger and D. Ferreira.

Phytochemistry 1994, 35 (6), 1559 - 1565.

DOI:  https://doi.org/10.1016/S0031-9422(00)86894-6

 

The Occurrence of Phenylpyruvic Acid in Woody Plants:  Biosynthetic Significance.

C. Marais, J.A. Steenkamp and D. Ferreira.

Tetrahedron Letters 1996, 37 (32), 5763 – 5764.

DOI:  https://doi.org/10.1016/0040-4039(96)01178-1

 

The Occurrence of Phenylpyruvic Acid in Woody Plants:  Biosynthetic Significance and Synthesis of an Enolic Glucoside Derivative.

C. Marais, J.A. Steenkamp, D. Ferreira.

J. Chem. Soc., Perkin Trans. I 1996, 2915 – 2918.

DOI: 10.1039/P19960002915

 

(S)- and (R)-Eriodictyol-6-C-b-D-glucopyranoside, novel keys to the fermentation of rooibos (Aspalathus linearis).

C. Marais, W. Janse van Rensburg, D. Ferreira and J.A. Steenkamp.

Phytochemistry 2000, 55, 43 –49.

DOI:  https://doi.org/10.1016/S0031-9422(00)00182-5

 

Two new promelacacinidin dimers including a novel flavanone-flavanol dimer characterised by a unique C(3)-C(4) linkage, from the heartwood of Acacia nigrescens.

H. Howell, E. Malan, D.J. Brand, B.I. Kamara, B.C.B. Bezuidenhoudt, C. Marais and J.A. Steenkamp.

Chemistry of Natural Compounds 2007, 43 (5), 533 – 538.

DOI:  https://doi.org/10.1007/s10600-007-0184-0

 

Enantio-enriched dihydroflavonols via stereoselective a-hydroxylation of flavanones.  Biosynthetic significance.

Z.M. Border, W. Janse van Rensburg, C. Marais and J.A. Steenkamp.

Aust. J. Chem. 2008, 61, 122 – 130.

DOI:  https://doi.org/10.1071/CH07325

 

Regioselective hydrogenation of a,ß-unsaturated ketones with Wilkinson’s catalyst.

J.H. van Tonder, C. Marais, D. J. Cole-Hamilton and B.C.B. Bezuidenhoudt.

Synthesis 2010, 3, 421 – 424.

DOI:  10.1016/j.tetlet.2011.12.060

 

Catalytic epoxidation of stilbenes with non-peripherally alkyl substituted carbonyl ruthenium phthalocyanine complexes.

C.A. Enow, C. Marais and B.C.B. Bezuidenhoudt

Journal of Porphyrins and Phthalocyanines 2012, 16, 403 – 412.

DOI: 10.1142/S1088424612500459

 

Al(OTf)3:  An Efficient Recyclable Catalyst for Direct Nucleophilic Substitution of the Hydroxyl group of Propargylic Alcohols with Carbon and Heteroatom Centered Nucleophiles to Construct C-C, C-O, C-N and C-S bonds.

M. Gohain, C. Marais and B.C.B. Bezuidenhoudt.

Tetrahedron Letters 2012, 53, 1048 -1050.

DOI:  10.1016/j.tetlet.2011.12.060

 

Ring closing metathesis as new methodology for the synthesis of monomeric flavonoids.

Bradley J. Miller, Tanya Pieterse, Charlene Marais, Barend C.B. Bezuidenhoudt

Tetrahedron Letters 2012, 53, 4708 – 4710.

DOI:  http://dx.doi.org/10.1016/j.tetlet.2012.06.094

 

An Al(OTf)3-catalyzed environmental benign process for the propargylation of indoles.

M. Gohain, C. Marais and B.C.B. Bezuidenhoudt

Tetrahedron Letters 2012, 53, 4704 – 4707.

DOI:  http://dx.doi.org/10.1016/j.tetlet.2012.06.095

 

Al(OTf)3 catalysed Friedel-Crafts Michael type addition of indoles to a,ß-unsaturated ketones with PEG-200 as recyclable solvent.

M. Gohain, Jc Jacobs, C. Marais and B.C.B. Bezuidenhoudt

Australian Journal of Chemistry 2013, 66, 1594-1599.

 

Thermo-analytical determination of intermediates in the copper catalysed rearrangement of o-toluic acid to meta-cresol.

A.C. Sunil, E.H.G. Langner, C. Marais and B.C.B. Bezuidenhoudt.

Catal. Sci. Technol. 2013, 3, 2227 – 2233.

DOI:  10.1016/j.tetlet.2011.12.060

 

Non-peripherally substituted phthalocyanines as catalysts in the epoxidation of alkenes.

C.A. Enow, C. Marais and B.C.B. Bezuidenhoudt

Journal of Porphyrins and Phthalocyanines 2015, 19, 582-594.

DOI: 10.1142/S108842461450103X

 

Al(OTf)3:   An efficient Lewis Acid additive for domino addition-elimination of Grignard Reagents to activated ketones.

Tanya Pieterse, Melanie Visser, Charlene Marais and Barend B.C. Bezuidenhoudt

Synlett 2016, 27, 1541-1546.

DOI: 10.1055/s-0035-1561401

 

Parameters Influencing Activity and Regioselectivity in the Methoxycarbonylation of Arylalkenes.

Maretha du Plessis, Charlene Marais and B.C.B. Bezuidenhoudt

Synthesis 2016, 4 (48), 557-565.

DOI: 10.1055/s-0035-1560912

 

Performance in Chemistry of students who started in the University Preparation Programme: The ripple effect

Charlene Marais, Rina Meintjes, C. Robert Dennis, Jannie C. Swarts

South African Journal of Science 2016, 112 (7/8), Art. #a0162, 3 pages.

DOI: https://doi.org/10.17159/sajs.2016/a0162

 

The Extended BSc Programme:  Performance of students in Chemistry

C. Robert Dennis, Rina Meintjes, Charlene Marais, Ricky Versteeg and Jannie C. Swarts

South African Journal of Science 2017, 113 (9/10), Art. #a0229, 4 pages.

DOI:   http://dx.doi.org/10.17159/sajs.2017/a0229 

 

A variable temperature NMR analysis and resonance assignment of the Grubbs second generation catalyst

Marthinus Rudi Swart, Linette Twigge, Charlene Marais, Barend Christiaan Buurman Bezuidenhoudt

Polyhedron 2018, 152, 31-36.

DOI:  https://doi.org/10.1016/j.poly.2018.06.024

 

Crystal structure of 3-(4-methoxyphenyl)-1-phenylprop-2-yn-1-one, C16H12O2

Jireh B. M. Smit, Charlene Marais, Frederick P. Malan, Barend C. B. Bezuidenhoudt

Z. Kristallogr. NCS 2019; 234(2): 359–360.

DOI: https://doi.org/10.1515/ncrs-2018-0418

 

Crystal structure of 2,4-dimethoxybenzyl-triphenylphosphonium trifluoroacetate

trifluoroacetic acid solvate, C31H27F6O6P

Jireh B. M. Smit, Charlene Marais, Frederick P. Malan, Barend C. B. Bezuidenhoudt

Z. Kristallogr. NCS 2019, 234(4): 621–623.

DOI: https://doi.org/10.1515/ncrs-2018-0573

 

 

 

Area(s) of Interest

Organic synthesis

Catalysis

Natural product chemistry

Courses Presented

CHEM1623 (Organic Chemistry)

CHEM1551

CHEM1661

CHEM2621

CHEM6853 (Retrosynthesis)


FACULTY CONTACT

Please contact us by email for assistance.
We are currently not in our offices, as per the lockdown measures in place for South Africa.


Marketing Manager: Elfrieda Lötter
T: +27 51 401 2531
E: lottere@ufs.ac.za

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