Prof Anke Wilhelm
Associate Professor
2 105
IB 48
Chemistry Building 105

Short CV

Dr Anke Wilhelm completed her MSc degree in 2008 in Organic Chemistry investigating the photochemistry of catechin and epicatechin. She obtained her PhD degree in Organic Chemistry in 2013, at the University of the Free State, under the supervision of the late Prof JH van der investigating the syntheses and biological activity of nitrogen containing chalcones and analogues. 

She currently heads the Organic Chemistry division and is a senior lecturer in Organic Chemistry. She is the manager of the zebrafish bioassay at the Chemistry department. Her main research focus is isolation of active GABAergic compounds utilising a larval zebrafish locomotor bioassay. She has completed research visits to the University of Cambridge, United Kingdom, the University of Innsbruck, Austria and the University of Basel, Switzerland. An established collaboration with the University of Vienna, Austria, investigates the GABAergic activity of South African botanicals in the search of novel anti-epileptic drugs.



Publications (Short List)

Wilhelm-Mouton, A.; Bonnet, S.L.; Ding, Y.; Li, X-C.; Ferreira, D. and Van Der Westhuizen, J.H. Photochemistry synthesis. Part 2:  Enantiomerically pure polyhydroxy-1,1,3-triarylpropan-2-ols, J. Photochem. Photobiol. A: Chem. (2011), DOI: 10.1016/j.jphotochem.2011.10.019 (Impact factor: 2.291)


Efrem T Abay, Jan H van der Westhuizen, Kenneth J Swart, Liezl Gibhard, Nina Lawrence, Ntokozo Dambuza, Anke Wilhelm, Kendrekar Pravin and Lubbe Wiesner. Efficacy and pharmacokinetic evaluation of a novel anti-malarial compound (NP046) in a mouse model, Malaria Journal, (2015), 14:8, DOI: 10.1186/1475-2875-14-8 (Impact factor: 3.490)


Kun Du, Maria De Mieri, Priyanka Saxena, Khanya V. Phungula, Anke Wilhelm, Madalina Marina Hrubaru, Elmarie van Rensburg, Pieter C. Zietsman, Steffen Hering, Jan H. van der Westhuizen, Matthias Hamburger. HPLC-Based Activity Profiling for hERG Channel Inhibitors in the South African Medicinal Plant Galenia africana, Planta Med, (2015), DOI:10.1055/s-0035-1545929 (Impact factor: 2.152)


Wilhelm, A.; Kendrekar, P.; Noreljaleel, A. E. M.; Abay, E.; Bonnet, S. L.; Wiesner, L.; de Cock, C.; Swart, K. and van der Westhuizen, J. H. Syntheses and in vitro antiplasmodial activity of aminoalkylated chalcones and analogues, J. Nat. Prod. (2015), DOI: 10.1021/acs.jnatprod.5b00114 (Impact factor: 3.662)


Wilhelm, A.; van der Westhuizen, J.H.; Phungula, K.V.; van Rensburg, E.; Zietsman, P.C.; Hering, S. An investigation into consumed South African plant species as potential hERG channel blockers, Planta Med. (2015), (Impact factor: 2.152)


Bonnet, S.L.; Wilhelm, A.; Willcox, M.; Phungula, K.V. Retrospective treatment outcome analysis on the use of medicinal plants to alleviate diarrhea in the Thaba Nchu area of the Free State Province, South Africa,Planta Med. (2015), DOI: 10.1055/s-0035-1565723 (Impact factor : 2.152)


Liezl Gibhard, Kendrekar Pravin, Efrem Abay, Dale Taylor, Anke Wilhelm, Kenneth Swart, Nina Lawrence, Rosal Khoury, Jan van der Westhuizen, Peter Smith and Lubbe Wiesner. In vitro and in vivo Pharmacokinetics of Aminoalkylated Diarylpropanes NP085 and NP102. American Society for Microbiology Antimicrobial Agents and Chemotherapy (2016) 60:5 3065-3069, DOI: 10.1128/AAC.02104-15 (Impact factor: 3.340)


Jerald J. Nair, Johannes van Staden, Susanna L. Bonnet and Anke Wilhelm. Distribution and diversity of usage of the Amaryllidaceae in the traditional remediation of infectious diseases. Natural Product Communications (2017) 12:4 635-639 (Impact factor: 0.884)


Fahimeh Moradi-Afrapoli, Hannes van der Merwe, Maria De Mieri, Anke Wilhelm, Marco Stadler, Pieter C. Zietsman, Steffen Hering, Kenneth Swart, Matthias Hamburger. HPLC-Based Activity Profiling for GABAAReceptor Modulators in Searsia pyroides using a larval Zebrafish locomotor assay. Planta Med. (2017) DOI: 10.1055/s-0043-110768 (Impact factor: 2.152)


J.J. Nair, J. van Staden, S.L. Bonnet, A. Wilhelm. Antibacterial properties of the family Amaryllidaceae: evaluation of plant extracts in vitro. Natural Product Communications (2017) 12:7 1145-1151 (Impact factor: 0.884)


E. van Rensburg, P.C. Zietsman, S.L. Bonnet, A. Wilhelm. Alkaloids from the Bulbs of Boophone disticha. Natural Product Communications (2017) 12(9) 1431-1433 (Impact factor: 0.884)


Jerald J. Nair, Anke Wilhelm, Susanna L. Bonnet, Johannes van Staden, Antibacterial constituents of the plant family Amaryllidaceae, Bioorganic & Medicinal Chemistry Letters (2017) 27 4943 – 4951, DOI:10.1016/j.bmcl.2017.09.052 (Impact factor: 2.454)


C.E. Mair, U. Grienke, A. Wilhelm, E. Urban, M. Zehl, Michaela Schmidtke, J.M. Rollinger. Anti-Influenza Triterpene Saponins from the bark of Burkea africana. Journal of Natural Products (2018) 81 515 – 523 (Impact factor: 4.257)


Anwar E. M. Noreljaleel, A. Wilhelm, S. L. Bonnet, and J. H. van der Westhuizen. Synthesis and Bioactivity of Reduced Chalcones Containing Sulfonamide Side Chains. Journal of Natural Products (2018) 81 41 - 48 (Impact factor: 4.257)


Nova Syafni, Fahimeh Moradi-Afrapoli, Ombeline Danton, Anke Wilhelm, Marco Stadler, Steffen Hering, Olivier Potterat and Matthias Hamburger, HPLC-Based Activity Profiling for GABAA Receptor Modulators in Murraya exotica. Natural Product Communications (2019) (Impact factor: 0.884)


Anwar E.M. Noreljaleel, Gabré Kemp, Anke Wilhelm, Jan H. van der Westhuizen, Susan L. Bonnet, Analysis of commercial proanthocyanidins. Part 5: A high resolution mass spectrometry investigation of the chemical composition of sulfited wattle (Acacia mearnsii De Wild.) bark extract. Phytochemistry (2019) (Impact factor: 2.905)


Mohale B. Mabaleha, Pieter C. Zietsman, Anke Wilhelm, and Susan L. Bonnet. Ethnobotanical Survey of Medicinal Plants Used to Treat Mental Illnesses in the Berea, Leribe, and Maseru Districts of Lesotho, Natural Product Communications, (2019)


Mc Jesus Kinyok, Anke Wilhelm, Eutrophe Le Doux Kamto, Joséphine Ngo Mbing, Susanna L. Bonnet & Dieudonné Emmanuel Pegnyemb. Chemical constituents of the leaves of Anthonotha macrophylla (Leguminosae), Natural Product Research, (2020) 1478-6427. Pp1-9


Anwar E. M. NorEljaleel, Anke Wilhelm, and Susan L. Bonnet, Analysis of commercial proanthocyanidins. Part 6: Sulfitation of flavan-3-ols catechin and epicatechin, and procyanidin B-3, Molecules (2020) 25(21), 4980.


Eutrophe Le Doux Kamto, Olivier Placide Note, Mc Jesus Kinyok, Anke Wilhelm, Josephine Ngo Mbing, Cyril Antheaume, Alex de Theodore Atchade, Dieudonne Emmanuel Pegnyemb, Derek Tantoh Ndinteh,  Mohamed Haddad, Susan L. Bonnet, Glycosides of polygalacic acid from the stem barks of Piper guineense Schum and Thonn, Carbohydrate Research (2021) 507, 108374.


Area(s) of Interest

Synthetic Organic Chemistry


Bioavailability of novel synthetic compounds 

Natural Product Chemistry


Medicinal Chemistry

Courses Presented






Community Service

Supporter of New Beginnings in Bloemfontein. They run a rescue center for abused and neglected animals. I adopted two rescue doggies from New Beginnings and I am an avid supporter of their cause. I donate money monthly as well as food for the rescue doggies. Animals are my passion.

Drop off point and organizer for the Bloemfontein area of the SANTA CAUSE FOR PAWS drive which takes place over November and December each year.


Elfrieda van den Berg (Marketing Manager)
T: +27 51 401 2531


Dilahlwane Mohono (Faculty Officer)
T: +27 58 718 5284

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