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08 February 2021 | Story André Damons | Photo Charl Devenish
Prof Mamello Sekhoacha, Associate Professor from the Department of Pharmacology in the Faculty of Health Sciences, was appointed by Dr Zweli Mkhize, Minister of Health, as the new chairperson of the National Health Research Ethics Council of South Africa (NHREC).

A researcher in the field of drug discovery and development at the University of the Free State (UFS) has been appointed by Dr Zweli Mkhize, Minister of Health, as the new chairperson of the National Health Research Ethics Council of South Africa (NHREC).

Prof Mamello Sekhoacha, Associate Professor from the Department of Pharmacology in the Faculty of Health Sciences, was appointed as a member of the NHREC council in 2013, and later became the chairperson of the NHREC’s Norms and Standards Committee responsible for developing and revising guidelines for health research. Prof Sekhoacha was appointed deputy chairperson of the council in 2018 and has played an integral part in setting ethical standards for conducting health research in the country.

 Responsibilities of the NHREC

The NHREC is the national statutory body responsible for the governance and advancement of health research ethics in South Africa. Some of the responsibilities of the council are to set ethical norms and standards for health research by developing and revising the guidelines pertaining to health research; to promote and monitor compliance with existing regulations by health research ethics committees; and to build capacity in research ethics committees through robust registration and audit processes.

These responsibilities of the NHREC rest on the need to ensure ethical integrity in research involving human participants and animal subjects, and that research is based on sound scientific and ethical principles.

“It is an honour for me to serve on the NHREC for the third term. The NHREC has achieved remarkable outputs over the past three years, and I believe, given the current composition of the council members, this momentum will not be lost. One of the goals of the NHREC is to further broaden the scope of the ethics in health research guidelines from ‘biomedical research’ to ‘health-related research’ to ensure that adequate guidance is provided for those in health-related disciplines, as a response to the changing environment of research involving humans and the broader meaning of health research.” 

“We need more comprehensive guidelines with nuanced commentaries to indicate how the ethical principles that emanated from biomedical research involving humans, could be effectively implemented in other disciplines of health-related research,” says Prof Sekhoacha. 

Global paradigm shift in role and integration of ethics in health research

Having been a council member since 2013, Prof Sekhoacha, whose training spans from pre-clinical laboratory experimentation, the use of animals in research, clinical trials, and working with indigenous communities, says there is a global paradigm shift in the role and integration of ethics in health research in almost all aspects of research, with an increased emphasis on the scientific and social value of research: the prospect of generating the knowledge in a manner that protects and promotes people's health. Considerations of the NHREC go beyond developing ethical guidelines or ensuring the efficient functioning of the ethics committees, to raising awareness among research institutions and researchers to continually promote ethically sound research conduct. 

The subject of ethics in health research is pivotal and reflective of the values of both the institution and the country at large. 

UFS uses Prof Sekhoacha’s expertise on ethics

Prof Sekhoacha is also a co-opted advisory member in the Senate Research Ethics Committee of the UFS and facilitates workshops and seminars on research ethics offered by the Postgraduate School.

Prof Corli Witthuhn, Vice-Rector: Research and Internationalisation, says it is a great honour for the UFS that Prof Sekhoacha has been elected chair of the NHREC.  “The NHREC governs the research ethics processes in South Africa, and it is strategically important for the UFS to now have one of our own academics play such a nationally important role.  We have been using Prof Sekhoacha’s expertise on issues of ethics and we are looking forward to working with her to continue to better our own ethics processes.”

News Archive

Otorhinolaryngology research hopes to decrease morbidity
2016-10-04

Description: Prof Riaz Seedat Tags: Prof Riaz Seedat

Prof Riaz Seedat, Head of the
Department of
Otorhinolaryngology at the UFS

Prof Riaz Seedat, Head of the Department of Otorhinolaryngology at the UFS is a world-renowned ear, nose and throat specialist and researcher. He is also a National Research Foundation C3 rated scientist.

He is conducting his research in ear, nose and throat (ENT) pathology in a developing world setting, particularly focusing on recurrent respiratory papillomatosis and other ENT conditions. “This condition is caused by human papillomavirus (HPV), infective conditions as well as allergic rhinitis,” said Prof Seedat.

Current research is aimed at further describing the epidemiology of recurrent respiratory papillomatosis, identification of the HPV variants responsible for causing the condition and markers of disease aggressiveness.

The research has led to various international partnerships such as the multicentre collaborative studies, “Genetic Susceptibility to Papilloma-induced Voice Disturbance” at the Centre for Genomic Sciences at the Allegheny-Singer Research Institute in Pittsburgh, United States, and the HPV6/11 Global Diversity Consortium at the University of Ljubljana in Slovenia.

Although most head and neck squamous cell carcinomas are caused by excessive tobacco and alcohol use, there is an increasing body of evidence to show that HPV causes a subset of head and neck squamous cell carcinomas. However, there are few studies on the role of HPV in head and neck neoplasms in developing countries.

“Through the research we have shown that recurrent respiratory papillomatosis, caused by HPV, is not as rare in South Africa as it is in developed countries and that patients usually present respiratory papillomatosis at an advanced stage when the condition is life-threatening,” said Prof Seedat.

“It is hoped that this research will help us to address the morbidity caused by ENT conditions common in developing countries,” said Prof Seedat.

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