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UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

UFS receives research grant focusing on enablement of non-profit organisations

2011-01-20

Prof. Mabel Erasmus

The University of the Free State (UFS) has received a research grant to the value of R1,1 million from the National Research Foundation (NRF) to conduct research on community engagement, with the emphasis on knowledge as enablement – a Non-Profit Organisation (NPO) focus.

This was the first time the NRF had requested applications for research with a focus on community engagement (CE). With the grant, the UFS has become one of the first recipients of a research grant that focuses on community engagement.

The overarching research question that will be dealt with is how Higher Education Institutions (HEI) and the NPO sector can establish long-term, research-based collaborative engagements that will be mutually empowering and enabling through joint, reciprocal knowledge-based activities and capacity building.

The contention that this proposal is based on, is that HEIs have limited knowledge of the NPO sector and thus are unable to be fully responsive to the challenges that NPOs face. What is more, it is very likely that staff and students from HEIs do not have an adequate grasp of the experiential understanding, contextual community knowledge and practical know-how that NPO practitioners have, and hence do not appreciate the crucial contributions that they can make with regard to meaning-making processes aimed at improving some of the harsh South African realities.

According to Prof. Mabel Erasmus, Associate Professor and Head of the university’s Division: Service Learning, which submitted the research proposal to the NRF and is the grant-holder, the university would like the information generated by the research to be beneficial to both HEIs and the NPOs. “Knowledge regarding NPOs, specifically their challenges and information about what they are doing, will be invaluable to HEIs. At the same time, the research must benefit the NPOs with knowledge to improve their practice and strengthen their functioning.

“The research will take place in close collaboration with the NPOs, as their inputs are crucial. The research will thus not be ‘about’ them but ‘with’ them.”

“We do not want to send our students for community-based education or as volunteers to NPOs year after year and it does not mean as much to them as these organisations would hope for. With the research process we would like to strengthen NPOs, to build their capacity and give them our whole-hearted cooperation,” she said.

Funding received from the grant will be applied over a period of three years. Except for the study grants for five Ph.D. students and four master’s students, the grant will further make provision for a number of workshops, a local conference, a publication and presentations at international conferences on this matter. The research team of 22 persons includes academics from other HEIs such as the Central University of Technology, University of Zululand, University of Johannesburg and Monash SA. Several staff members of NPOs also form part of the team, including REACH (Bfn), Childline (FS) and others.

Prof. Erasmus said that the UFS was one of a few institutions that were currently conducting research to this extent on the link between the NPO sector and HEIs within the field of community engagement.

Media Release
18 January 2011
Issued by: Lacea Loader
Director: Strategic Communication (actg)
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za

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