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18 April 2019 | Story Leonie Bolleurs | Photo Sonia Small
First Lady Visit
At a gathering with the First Lady and UFS management were, from the left: Prof Prakash Naidoo, Vice-Rector: Operations; Prof Maléne Campbell; Chacha; Dr Tshepo Motsepe, First Lady of South Africa; Prof Petersen; Prof Puleng Lenka-Bula; Vice-Rector: Institutional Change, Student Affairs, and Community Engagement; and Prof Danie Vermeulen, Dean of the Faculty of Natural and Agricultural Sciences.

“I am from a very small town called Marquard. I am a granny’s boy – who was a domestic worker – and can speak fluent Afrikaans. I am fearless and I understand my calling for greatness. I stand and advocate for social justice and I am not scared to challenge any form of injustice. I hate people who abuse power and I am no friend of mediocrity. I speak my mind.”

This and much more describes Thapelo Chacha, a graduate in the Department of Urban and Regional Planning, who received his Honours degree in Spatial Planning at the recent April graduation ceremonies of the University of the Free State (UFS). 

The First Lady

He is also the student who brought Dr Tshepo Motsepe, the First Lady of South Africa to Kovsies. 

Chacha tells his story: “I met the First Lady some years back through Dr Vuyelwa Manzana, who was my mother’s doctor at the time – after dropping out of university due to a financial crisis. I was handed over to the lawyers, with a debt that accrued over three years. I knocked at every door you can think of – with no luck. One day I got a call from a lady who introduced herself as Mme Tshepo, asking me to go to university. I laughed, because I knew my debt was too big to allow me to study again. She insisted, and when I arrived at the UFS, my outstanding debt had been paid and I was able to register. The same Mme Tshepo called to assure me that she will pay for my tuition, meals, books, and accommodation. I did not even know that she was the wife of Mr Cyril Ramaphosa, who would later become the Deputy President and now the President of the country.”

“Mme Tshepo sponsored me from her own pocket until I became part of the Cyril Ramaphosa Education Trust (CRET).”

“She personally texted and called me about my graduation information so she could attend. You can imagine the excitement and the shock. Although I have met the First Lady many times, it will be the first time that I will introduce her to my family. She is taking me and my family – my mother and my grandmother – to lunch after the ceremony. I see that as a favour of God upon my life.”

Prof Francis Petersen, UFS Rector and Vice-Chancellor at a meeting with Dr Motsepe and Chacha said: “Access to university is crucial. However, we would also like our students to exit with a qualification. This is how a bursary like this one from CRET helps. We would like to exit students that contribute to the economy.”

Making a difference

Chacha is now doing his master’s in Urban and Regional Planning. “I am so looking forward to registering with the South African Council for Planners (SACPLAN) as a professional town planner at the end of my master’s degree within a few months. 

“I see myself joining a town planning division anywhere in South Africa, dedicated to changing the living conditions of ordinary citizens. Spatial planning speaks to the heart of land use and ensures that the land is used and occupied in a manner that is beneficial to everyone who needs it,” Chacha said. 

He believes town planning has been largely influenced by politics, thus forcing town planners to move away from serving the needs of the ordinary citizen. Chacha would like to see the injustices of the past, especially with regard to townships, being addressed. “This is why my dissertation is about township infrastructure and the contribution it makes towards township economy.”

“I would like to see a South Africa that is centred on the well-being of its citizens. The older generation has fought the brutality of apartheid; our battle as the youth is to be academically equipped to fight and win the land battle,” he said.

Kovsie encounters

For Chacha, his studies in Urban and Regional Planning was very tough. But the support he received from his lecturers was immeasurable. “Prof Maléne Campbell, Head of the UFS Department of Urban and Regional Planning has the most competent team. This is the best department on campus, with no racial issues or unpleasant vibes. I just love the space.”

“The UFS has taught me resilience, hard work, the importance of networking, and the knowledge that you need to be radical when it comes to your future,” Chacha concluded.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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