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18 April 2019 | Story Leonie Bolleurs | Photo Sonia Small
First Lady Visit
At a gathering with the First Lady and UFS management were, from the left: Prof Prakash Naidoo, Vice-Rector: Operations; Prof Maléne Campbell; Chacha; Dr Tshepo Motsepe, First Lady of South Africa; Prof Petersen; Prof Puleng Lenka-Bula; Vice-Rector: Institutional Change, Student Affairs, and Community Engagement; and Prof Danie Vermeulen, Dean of the Faculty of Natural and Agricultural Sciences.

“I am from a very small town called Marquard. I am a granny’s boy – who was a domestic worker – and can speak fluent Afrikaans. I am fearless and I understand my calling for greatness. I stand and advocate for social justice and I am not scared to challenge any form of injustice. I hate people who abuse power and I am no friend of mediocrity. I speak my mind.”

This and much more describes Thapelo Chacha, a graduate in the Department of Urban and Regional Planning, who received his Honours degree in Spatial Planning at the recent April graduation ceremonies of the University of the Free State (UFS). 

The First Lady

He is also the student who brought Dr Tshepo Motsepe, the First Lady of South Africa to Kovsies. 

Chacha tells his story: “I met the First Lady some years back through Dr Vuyelwa Manzana, who was my mother’s doctor at the time – after dropping out of university due to a financial crisis. I was handed over to the lawyers, with a debt that accrued over three years. I knocked at every door you can think of – with no luck. One day I got a call from a lady who introduced herself as Mme Tshepo, asking me to go to university. I laughed, because I knew my debt was too big to allow me to study again. She insisted, and when I arrived at the UFS, my outstanding debt had been paid and I was able to register. The same Mme Tshepo called to assure me that she will pay for my tuition, meals, books, and accommodation. I did not even know that she was the wife of Mr Cyril Ramaphosa, who would later become the Deputy President and now the President of the country.”

“Mme Tshepo sponsored me from her own pocket until I became part of the Cyril Ramaphosa Education Trust (CRET).”

“She personally texted and called me about my graduation information so she could attend. You can imagine the excitement and the shock. Although I have met the First Lady many times, it will be the first time that I will introduce her to my family. She is taking me and my family – my mother and my grandmother – to lunch after the ceremony. I see that as a favour of God upon my life.”

Prof Francis Petersen, UFS Rector and Vice-Chancellor at a meeting with Dr Motsepe and Chacha said: “Access to university is crucial. However, we would also like our students to exit with a qualification. This is how a bursary like this one from CRET helps. We would like to exit students that contribute to the economy.”

Making a difference

Chacha is now doing his master’s in Urban and Regional Planning. “I am so looking forward to registering with the South African Council for Planners (SACPLAN) as a professional town planner at the end of my master’s degree within a few months. 

“I see myself joining a town planning division anywhere in South Africa, dedicated to changing the living conditions of ordinary citizens. Spatial planning speaks to the heart of land use and ensures that the land is used and occupied in a manner that is beneficial to everyone who needs it,” Chacha said. 

He believes town planning has been largely influenced by politics, thus forcing town planners to move away from serving the needs of the ordinary citizen. Chacha would like to see the injustices of the past, especially with regard to townships, being addressed. “This is why my dissertation is about township infrastructure and the contribution it makes towards township economy.”

“I would like to see a South Africa that is centred on the well-being of its citizens. The older generation has fought the brutality of apartheid; our battle as the youth is to be academically equipped to fight and win the land battle,” he said.

Kovsie encounters

For Chacha, his studies in Urban and Regional Planning was very tough. But the support he received from his lecturers was immeasurable. “Prof Maléne Campbell, Head of the UFS Department of Urban and Regional Planning has the most competent team. This is the best department on campus, with no racial issues or unpleasant vibes. I just love the space.”

“The UFS has taught me resilience, hard work, the importance of networking, and the knowledge that you need to be radical when it comes to your future,” Chacha concluded.

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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