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25 April 2019 | Story Rulanzen Martin | Photo Rulanzen Martin
SAGV Conference
From left; Dr Cilliers van den Berg, Head of the German Section; Prof Marianne Zappen-Thomson, President of SAGV and Dr Akila Ahouli, representative from GAS.

As much as it was a conference on Germanistik (German Studies) it also highlighted the international footprint of the University of the Free State (UFS) and the important role of international and national academic collaborations. 

The German Section in the Department Afrikaans and Dutch; German and French at the UFS hosted the second conference of the Association of German Studies in Southern Africa (SAGV) and German Studies in Sub-Saharan Africa (GAS) from 15-18 April 2019 on the UFS Bloemfontein Campus. 

“We are very proud to be hosting the conference. It is an international conference with delegates from overseas who are all working in German Studies or to use the German term Germanistik,” said Dr Cilliers van den Berg, Head of the German Section at the UFS. 

Waiting room in Germanistik explored

Warteräume (waiting rooms) was the theme of the four-day conference with various research papers on the role and/or value of these waiting rooms within Germanistik. “It is the transitional areas, within Germanistik, on every conceivable level,” said Van den Berg. The conference was sponsored by the embassies of Germany, Austria and Switzerland, as well as the German Academic Exchange Service and the Goethe Institute of Johannesburg.

“When I look at the theme of the conference it is extremely exciting because it reminds me of Homi Bhabha’s Third Spaces, liminal spaces and the in-betweeners,” said Prof Heidi Hudson, Dean of the Faculty of The Humanities. 

UFS and internationalisation


“One of the concepts we actively embrace is that of internationalisation. Globally and nationally, internationalisation has become accepted as one of the critical processes advancing the core business of universities,” said Prof Francis Petersen, Rector and Vice-Chancellor of the UFS.

The delegates who attended the conference were from countries which included, among others, Ethiopia, Burkina Faso, Italy, Kenya, Germany and Namibia as well as delegates from the universities of Stellenbosch, Pretoria, Rhodes and North-West. 

“You represent a multifaceted culture that has enriched our global academic and cultural landscape over many years: great minds like Goethe, Kafka, Beethoven, Mozart, Freud, and Einstein,” said Prof Petersen.


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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