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18 April 2019 | Story Eugene Seegers | Photo Stephen Collett
Prof Chris Hermans
Prof Chris Hermans, extraordinary professor at the UFS, presents his inaugural lecture, titled Theology in an Age of Contingency.

“The road ahead is empty / It’s paved with miles of the unknown.”

Prof Chris Hermans quoted these lines from the song The Road Ahead, by Dutch vocal group City to City to introduce his inaugural lecture in the Faculty of Theology and Religion on 27 February 2019. Prof Hermans, a veteran researcher in pastoral theology, empirical, and practical religious studies at the Radboud University Nijmegen in the Netherlands and an extraordinary professor at the UFS, chose as his theme Theology in the Age of Contingency, stating that the uncertainty of life has affected all disciplines in the academy, from the sciences, philosophy, and pedagogy, to theology itself.

Although contingency is often defined as a “future event ... which is possible but cannot be predicted with certainty” (Oxford English Dictionary), Prof Hermans stated that, in the context of theology, it has more to do with complexity, unpredictability, coexistence of cultures, and an increasing number of decisions people need to make in modern-day life. 

Changing lanes

Prof Hermans recounted a memory from his childhood to illustrate some aspects of contingency: “Growing up, my parents told me to cycle on the right side of the road. They knew what the right side was. Everything had a right side: What norms and values to live by, what was right or wrong, when to pray and which words to use. ... We now live in a different world.”

Prof Hermans’ inaugural lecture reflected on four tasks of practical theology and missiology. He further asserted that the content and aim of these tasks change from the perspective of contingency.

Contingency perspectives

From a sociological perspective, said Prof Hermans, contingency is a characteristic of the age of modernisation in which we live. He stated that in the modern age, people have a much greater choice of individual ‘action options’ as well as a growing number of experiences as a result. Expounding on this, he said, “The fact that I am a Christian, and another person Hindu or Muslim, is largely due to the fact that I was born within a Christian family. The fact that I am Christian is a possibility and an actuality, but not a necessity.”

Prof Hermans also helped listeners to understand other areas in which contingency plays a role, such as the binary logic used when determining modalities of truth, or changing world views and philosophies of being, or even in our ethos, our art of living, and outlook on life.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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