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17 April 2019 | Story Leonie Bolleurs
Science ambassadors
Friends Tekano Mbonani and Chaka Mofokeng are pursuing graduate degrees in respectively Physics at the University of the Free State (UFS) and Astronomy at the University of the Western Cape. The two got together and decided to reach out to the high school, Leseding Technical Secondary School, where they came from.

It was a full house as more than 120 learners packed the hall at the Leseding Technical Secondary School in the Free State, where two young Astronomy researchers had come home to tell their younger peers about their studies and career prospects across South Africa.

Chaka Mofokeng and Tekano Mbonani are both former learners at the high school. Currently pursuing graduate degrees – for Mbonani in Physics at the University of the Free State (UFS), and for Mofokeng in Astronomy at the University of the Western Cape – the two friends got together and decided to reach out to the high school where they came from.

The event took place in January before schoolwork, tests, and exam preparations are occupying learners’ minds, inviting them to think about the big picture – the future, and how to be part of it. This is timely, because in July last year, the MeerKAT radio telescope was inaugurated in the Karoo. The MeerKAT is the first step to the international SKA telescope project, but it is already one of the best radio telescopes in the world and has placed South Africa firmly on the world map of radio astronomy and engineering.

Building a bridge
“This project enables us to build a bridge between secondary and tertiary institutions. Currently focused on senior secondary students, we aim to promote science through outreach events and activities. Using science and technology-based activities and events, such as stargazing at an observatory or exploring the universe in a planetarium, we want to attract these future secondary graduates. We also provide mentorship, hoping to help them improve their academic performance in matric,” said Mbonani.

For a whole morning, they spoke about their journeys, about science, about the skills that scientists acquire during their studies and all the opportunities such studies open up in an era where the 4th Industrial Revolution is predicted to reduce the number of jobs in many traditional professions. They addressed their peers in both English and Sesotho.

Astronomy in South Africa contributes to critical-skills development. Investing in the MeerKAT, for example, meant that over a thousand bursaries were made available through the SKA South Africa Human Capacity Development programme. Young scientists like Mofokeng and Mbonani have the opportunity to be part of MeerKAT science projects through their studies, using machine learning and other skills that are high in demand in today’s world. This was one of the messages they brought home.

Gaining new skills

“As an Astronomy research student, I have gained skills such as data analysis, mathematical modelling, communication and writing, programming, and teamwork, among others. These are requirements for most companies and institutions. With the unfolding of the 4th Industrial Revolution, such skills sets make young and aspiring scientists the perfect candidates for making the most of future opportunities,” reflected Mofokeng.

Most of the learners said they have never attended a science-outreach event. They were inspired by the young scientists’ stories and nearly half of them said they could see themselves pursuing a career in science. The learners also expressed a strong interest in more events of this kind, as well as mentorship during Grades 11 and 12 from peers at university. They asked about the salaries earned by astronomers, how long the studies take, and where astronomers are working in South Africa.

This initiative, started by two bright young scientists, hopefully marks the beginning of many more events of this kind. Mofokeng and Mbonani are already planning what to do on their next trip home.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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