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07 August 2019 | Story Charlene Stanley | Photo Stephen Collett
Prof Francis Petersen, Prof Puleng LenkaBula, William Bulwane and Min Thoko Didiza
Prof Francis Petersen, UFS Rector and Vice-Chancellor; Prof Puleng LenkaBula, Vice-Rector: Institutional Change, Student Affairs, and Community Engagement; Mr Kwekwe William Bulwane, Free State MEC for Agriculture and Rural Development; and Ms Thoko Didiza, Minister of Agriculture, Land Reform and Rural Development, who presented the 2019 Charlotte Maxeke public lecture.

“This work is not for yourselves. Kill that spirit of self. Do not live above your people. Live with them.” 
These famous words by Charlotte Maxeke, one of South Africa’s leading academic and social pioneers, formed the thrust of Minister Thoko Didiza's public lecture in a packed Equitas Auditorium on the UFS Bloemfontein Campus, three days before South Africans celebrate Woman’s Day.

The Agriculture, Land Reform and Rural Development Minister urged her audience to heed the “rich lessons this remarkable woman holds for our generation today”, in a lecture with the topic: Feminist Leadership, Intergenerational Dialogue on Knowledge, Agriculture and Sustainable Futures.

Educational pioneer

Referring to Maxeke’s many academic and cultural achievements, Minister Didiza pointed out that, “Her educational achievements did not make her see her fellow Africans any differently. It made her want to change their lives for the better.”
She called Maxeke a “true feminist, with an inclusive vision to fight for the betterment of all South Africans”.

This was echoed by Prof Francis Petersen, UFS Rector and Vice-Chancellor, in his welcoming address. He singled out the fact that Maxeke used to spend long hours tutoring her less skilled classmates while still at school.
“This wonderful example of using your own knowledge to make a real impact in the lives of others, is something we at the University of the Free State truly salute,” he said.  

Women’s conversation on land

On the topic of land reform, Minister Didiza referred to the fact that countries all over the world were involved in a ‘continuous process’ of land reform. She appealed to all South Africans to get involved in dialogues around the land issue.
“I know the pain and the cries of African people when it relates to land. But I don’t hear the cries and concerns of our white compatriots. Because until we understand each other’s pain, we will never be able to navigate the future.”
Minister Didiza then called for a ‘women’s conversation on land’, as she believed women to be ‘calmer’ than men and more inclined to collaborate with and listen to one another on an issue that is vital to all South African communities. 

Knowledge should lead to action

Minister Didiza said she believed universities had an important role to play in “gaining collective knowledge to solve problems”, and that agriculture should be a key focus area here – “benefitting from innovations in other sectors”.
“We need to urgently revitalise agriculture to once again bring glory to the Free State,” she said.
 “Knowledge means nothing if not translated into action and solutions for the problems we face in South Africa,” she concluded.

The Charlotte Maxeke lecture has been presented annually since 2009. Previous speakers include Minister Angie Motshekga, Prof Hlengiwe Mkhize and Dr Frene Ginwala.
 
Who was Charlotte Maxeke?

The CMM Institute describes her in this way:
“Charlotte Mannya-Maxeke (1871–1919) was a pioneering South African woman who was passionate about inclusivity, education and evangelism. She grasped every opportunity presented to her and accomplished many notable firsts during her lifetime.”
These ‘firsts’ include:
- being the first black woman in South Africa to obtain a BSc degree (at Wilberforce University in the United States of America in 1901);
- being the first woman to participate in the King’s Courts under King Sabata Dalindyebo of the AbaThembu;
- being the first African woman to establish a school (in Evaton, with her husband, in 1908);
- being the only woman who attended and contributed to the first African National Congress (ANC) conference in 1912; and
- being the co-initiator, organiser, and first President of the Bantu Women’s League, founded in 1918.

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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